SPR206 acetate
- CAS No.
- 2408422-41-1
- Chemical Name:
- SPR206 acetate
- Synonyms
- SPR206 acetate
- CBNumber:
- CB48205874
- Molecular Formula:
- C54H86ClN15O14
- Molecular Weight:
- 1204.82
- MDL Number:
- MOL File:
- 2408422-41-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SPR206 acetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0133565 | SPR206 acetate 98.88% | 2408422-41-1 | 1mg | $412 | 2026-06-04 | Buy |
| ChemScene | CS-0133565 | SPR206 acetate 98.88% | 2408422-41-1 | 5mg | $1029 | 2026-06-04 | Buy |
| ChemScene | CS-0133565 | SPR206 acetate 98.88% | 2408422-41-1 | 10mg | $1625 | 2026-06-04 | Buy |
| ChemScene | CS-0133565 | SPR206 acetate 98.88% | 2408422-41-1 | 50mg | $4550 | 2026-06-04 | Buy |
| aablocks | AA01V7F6 | SPR206 acetate >98% | 2408422-41-1 | 1mg | $458 | 2026-05-31 | Buy |
SPR206 acetate Chemical Properties, Uses, Production
Uses
SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L[1][2].
in vivo
SPR206 (0.125-30 mg/kg; intravenous injection or subcutaneous injection; every 8 hours or every 4 hours; for 16 hours or 24 hours; neutropenic mice) treatment reduces the burden of Pa14 and NCTC13301 in lung tissue and in the thigh model[2].
| Animal Model: | Neutropenic mice infected Pa14 or NCTC13301[2] |
| Dosage: | 3 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg (intravenous injection); 0.125 mg/kg, 0.5 mg/kg, 1 mg/kg, 4 mg/kg (subcutaneous injection) |
| Administration: | Intravenous injection or subcutaneous injection; every 8 hours or every 4 hours; for 16 hours or 24 hours |
| Result: | In lung tissue, reduced the burden of Pa14 and NCTC13301 by 1.5 and 3.6 log10 CFU/mL. In the thigh model, reduced the burden of Ab13301 by 3.4 and 4.3 log10 CFU/g. |
References
[1] Brown P, et al. Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206. ACS Infect Dis. 2019 Oct 11;5(10):1645-1656. DOI:10.1021/acsinfecdis.9b00217
[2] L. Grosser, et al. In Vivo Efficacy of SPR206 in Murine Lung and Thigh Infection Models Caused by Multidrug Resistant Pathogens Pseudomonas aeruginosa and Acinetobacter baumanii. Poster-139 ASM ESCMID 2018 Lisbon, Portugal.
[3] Noushin Akhoundsadegh, et al. Outer Membrane Interaction Kinetics of New Polymyxin B Analogs in Gram-Negative Bacilli. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00935-19. DOI:10.1128/AAC.00935-19
SPR206 acetate Preparation Products And Raw materials
Raw materials
Preparation Products
SPR206 acetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-025-66113011 15955137747 | cb5@aikonchem.com | China | 10354 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
