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((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate structure

CAS No.: 144163-97-3

Chemical Name:: ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate

Synonyms: NCT;Ritonavir middle 2;5-(p-NitrophenoxycarbonyloxyMethyl);Thiazolylmethyl-4-nitrophenylcarbonate;4-Nitrophenyl 5-thiazolylmethyl carbonate;[(5-Thiazol)Methyl]-(4-nitrophenyl)carbonate;((5-Thiazolyl)methyl)-(4-nitrophenyl)carbote;4-Nitrophenyl (thiazol-5-ylMethyl) carbonate;((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate;((5-Isothiazolyl)methyl)-(4-nitrophenyl)carbonate

CBNumber:: CB4855282

Molecular Formula:: C11H8N2O5S

Molecular Weight:: 280.26

MDL Number:: MFCD09750981

MOL File:: 144163-97-3.mol

MSDS File:: SDS

Last updated:2026-05-08 10:32:36

Product description	Number	Pack Size	Price
4-Nitrophenyl (thiazol-5-ylmethyl) carbonate 97%	N55244	5g	$20
4-Nitrophenyl (thiazol-5-ylmethyl) carbonate 97%	N55244	10g	$24
4-Nitrophenyl (thiazol-5-ylmethyl) carbonate 97%	N55244	25g	$26
4-Nitrophenyl (thiazol-5-ylmethyl) carbonate 97%	N55244	100g	$70
Thiazolylmethyl-4-nitrophenylcarbonate	T344300	250mg	$95
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((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Properties

Melting point	65-67°C
Boiling point	475.3±45.0 °C(Predicted)
Density	1.485
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Chloroform, Ethyl Acetate (Slightly)
form	Solid
pka	1.86±0.10(Predicted)
color	Pale Yellow
InChI	InChI=1S/C11H8N2O5S/c14-11(17-6-10-5-12-7-19-10)18-9-3-1-8(2-4-9)13(15)16/h1-5,7H,6H2
InChIKey	FTEKBGGQRNJIPQ-UHFFFAOYSA-N
SMILES	C(OCC1SC=NC=1)(=O)OC1=CC=C([N+]([O-])=O)C=C1
CAS DataBase Reference	144163-97-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
REACH Registrations	Active

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	N55244	4-Nitrophenyl (thiazol-5-ylmethyl) carbonate 97%	144163-97-3	5g	$20	2026-05-06	Buy
Synthonix	N55244	4-Nitrophenyl (thiazol-5-ylmethyl) carbonate 97%	144163-97-3	10g	$24	2026-05-06	Buy
Synthonix	N55244	4-Nitrophenyl (thiazol-5-ylmethyl) carbonate 97%	144163-97-3	25g	$26	2026-05-06	Buy
Synthonix	N55244	4-Nitrophenyl (thiazol-5-ylmethyl) carbonate 97%	144163-97-3	100g	$70	2026-05-06	Buy
TRC	T344300	Thiazolylmethyl-4-nitrophenylcarbonate	144163-97-3	250mg	$95	2021-12-16	Buy

Product number	Packaging	Price	Buy
N55244	5g	$20	Buy
N55244	10g	$24	Buy
N55244	25g	$26	Buy
N55244	100g	$70	Buy
T344300	250mg	$95	Buy

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Chemical Properties,Uses,Production

Chemical Properties

Pale-Yellow Solid

Uses

Retinovir intermediate.

Synthesis

38585-74-9

5070-13-3

144163-97-3

General procedure for the synthesis of ((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate (compound 9) from 5-hydroxymethylthiazole (compound 8, 17 mmol) and bis(p-nitrophenyl)carbonate (compound 7, 19 mmol): compound 7 was added to a dichloromethane (DCM, 40 mL) solution of compound 8, followed by triethylamine (26 mmol) . The reaction mixture was stirred at room temperature for 12 h. After completion of the reaction it was concentrated under reduced pressure. The concentrated mixture was diluted with ethyl acetate (EtOAc) and washed sequentially with saturated aqueous sodium carbonate (Na2CO3) solution, water and brine. After washing, the organic solvent was removed under reduced pressure. The residue was purified by fast column chromatography (silica gel as stationary phase, eluent ratio hexane/ethyl acetate=1/1) to give the final compound 9 (4.7 g).

References

[1] Patent: WO2008/10921, 2008, A2. Location in patent: Page/Page column 188-189
[2] Patent: US2010/256366, 2010, A1. Location in patent: Page/Page column 19
[3] Patent: EP2231628, 2015, B1. Location in patent: Paragraph 0878
[4] Patent: US2018/30043, 2018, A1. Location in patent: Paragraph 0163

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Preparation Products And Raw materials

Raw materials

5-Hydroxymethylthiazole BIS(4-NITROPHENYL) CARBONATE Triethylamine Dichloromethane

Preparation Products

thiazol-5-ylmethyl ((2R,5R)-5-amino-1,6-diphenylhexan-2-yl)carbamate

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Suppliers

Global( 239)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29817	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
SIMAGCHEM CORP	58
Hubei Ipure Biology Co., Ltd	58

View Lastest Price from ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-11-18	((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3	US $1.10 / g	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2025-05-26	((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate 144163-97-3	US $10.70 / KG	10KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3
US $1.10 / g
99.0% Min
Dideu Industries Group Limited

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
144163-97-3
US $10.70 / KG
99%
Hebei Chuanghai Biotechnology Co,.LTD

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate Spectrum

((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate(144163-97-3)¹HNMR

144163-97-3(((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate)Related Search:

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Methyl Thiazole ((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate hydrochloride

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5-(p-NitrophenoxycarbonyloxyMethyl) [(5-Thiazol)Methyl]-(4-nitrophenyl)carbonate ((5-thiazolyl)Methyl)-(4-nitrophenyl)carbonate (SC) NCT 4-Nitrophenyl (thiazol-5-ylMethyl) carbonate ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbote carbonic acid 4-nitrophenyl 5-thiazolylmethyl ester RITONAVIR INTERMEDIATE-A THIOZOLE [CARBONIC ACID-4NITROPHENYL-5-THIAZOLYLMETHYLESTER (NCT) ((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate Thiazolylmethyl-4-nitrophenylcarbonate carbonic acid [4-nitro-2-(5-thiazolylmethyl)phenyl] ester ((5-thiazolyl)methyl)-(4-nitrophenyl)carbonate ( for Antiviral Drugs ) ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate in stock GMP Factory ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT) Ritonavir intermediate/Thiazolylmethyl-4-nitrophenylcarbonate ((5-THIAZOLYL)METHYL)-(4-NITROPHENYL)CARBONATE / RITONAVIR INTERMEDIATE/ CAS:144163-97-3 ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate ISO 9001：2015 REACH 4-Nitrophenyl-5-thiazolylcarbonic acid methyl ester Ritonavir middle 2 4-Nitrophenyl 5-thiazolylmethyl carbonate (5-Thiazolyl)methyl-(4-nitrophenyl) carbonate (NPTC) ((5-Isothiazolyl)methyl)-(4-nitrophenyl)carbonate Carbonic acid 4-nitrophenyl 5-thiazolylmethyl este 144163-97-3 44163-97-3 144163-77-3 Heterocyclic Compounds Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Ritonavir API intermediates