Penicillin G potassium salt
- CAS No.
- 113-98-4
- Chemical Name:
- Penicillin G potassium salt
- Synonyms
- PENICILLIN G POTASSIUM;BENZYLPENICILLIN POTASSIUM;PENICILLIN G POTASSIUM SALT;pfizerpen;Penicilline G;potassium [2s-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;Pen-G;forpen;PENICILLINE G POTASSIUM;R-Pen
- CBNumber:
- CB4855484
- Molecular Formula:
- C16H17KN2O4S
- Molecular Weight:
- 372.48
- MDL Number:
- MFCD00036193
- MOL File:
- 113-98-4.mol
| Product description | Number | Pack Size | Price |
| Penicillin G potassium salt ~1600?U/mg | PENK | 1000000units | $27.4 |
| Penicillin G potassium salt ~1600?U/mg | PENK | 10000000units | $34.8 |
| Penicillin G Potassium Pharmaceutical Secondary Standard; Certified Reference Material | PHR2640 | 500MG | $216 |
| Penicillin G potassium salt ~1600?U/mg | PENK | 100000000units | $149.96 |
| Penicillin G potassium salt powder, BioReagent, suitable for cell culture | P7794 | 1000000units | $23.1 |
| More product size | |||
| Melting point | 214-217 C |
|---|---|
| alpha | D22 +285° (c = 0.748 in water) |
| refractive index | 294 ° (C=1, H2O) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | H2O: 100 mg/mL |
| form | powder |
| color | Needles from butanol (aq) |
| PH | pH (10g/L, 25℃) : 5.0～7.5 |
| Water Solubility | Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform. |
| Merck | 14,7094 |
| BRN | 3832841 |
| Stability | Hygroscopic |
| InChIKey | IYNDLOXRXUOGIU-LQDWTQKMSA-M |
| SMILES | N12C([C@@H](NC(=O)CC3=CC=CC=C3)[C@@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O.[K+] |&1:2,13,19,r| |
| FDA UNII | VL775ZTH4C |
| EPA Substance Registry System | Penicillin G Potassium (113-98-4) |
| UNSPSC Code | 12352207 |
| NACRES | NA.76 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P362+P364 | |||||||||
| Hazard Codes | Xn,C,F | |||||||||
| Risk Statements | 42/43-34-11 | |||||||||
| Safety Statements | 36/37-45-36/37/39-26-16-60-37-24-22 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | XH9700000 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29411000 | |||||||||
| Toxicity | LD50 oral in rabbit: 5848mg/kg | |||||||||
| NFPA 704 |
|
Penicillin G potassium salt price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PENK | Penicillin G potassium salt ~1600?U/mg | 113-98-4 | 1000000units | $27.4 | 2025-07-31 | Buy |
| Sigma-Aldrich | PENK | Penicillin G potassium salt ~1600?U/mg | 113-98-4 | 10000000units | $34.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHR2640 | Penicillin G Potassium Pharmaceutical Secondary Standard; Certified Reference Material | 113-98-4 | 500MG | $216 | 2025-07-31 | Buy |
| Sigma-Aldrich | PENK | Penicillin G potassium salt ~1600?U/mg | 113-98-4 | 100000000units | $149.96 | 2025-07-31 | Buy |
| Sigma-Aldrich | P7794 | Penicillin G potassium salt powder, BioReagent, suitable for cell culture | 113-98-4 | 1000000units | $23.1 | 2025-07-31 | Buy |
Penicillin G potassium salt Chemical Properties,Uses,Production
Description
Benzylpenicillin potassiumwas the first crystalline penicillin produced on an industrial scale , . It is produced in the pure state by the addition of phenylacetate to a culture of Penicillium chrysogenum. The crystalline benzylpenicillin potassium contains 1598 U/mg.
Chemical Properties
Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase.
Uses
Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.
Preparation
Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.
Definition
ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).
brand name
Pentids (Apothecon); Pfizerpen (Pfizer).
General Description
Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.
Biochem/physiol Actions
Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.
Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.
Safety Profile
Poison by intracerebral andintravenous routes. Moderately toxic by intraperitonealroute. Mutation data reported. See other penicillin entries.When heated to decomposition it emits toxic fumes ofNOx and SOx.
Synthesis
61-33-6
113-98-4
Synthesis of (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid as (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2- Potassium carboxylate was performed in the following general steps: first, 1000 mL of the activated charcoal-treated extract (containing about 100,000 Oxford units of penicillin G/mL) was dissolved in n-butyl acetate. Subsequently, a 50% (w/w) aqueous solution of K2CO3 was added to this solution, ensuring that the molar amount of potassium in the mixture was about 1.0 equivalent of penicillin G. Next, a volume of liquid was evaporated by heating the mixture under vacuum using a rotary film evaporator (bath temperature 45-48°C) (see Table 1 for specific evaporation volumes). After evaporation was completed, methanol was added to the residue and stirred at 25°C for 1 hour. Afterwards, the suspension was filtered and the wet filter cake was washed with 70 mL of n-butyl acetate and finally the wet filter cake was dried. Table 1 details the total volume of evaporation and the volume of the aqueous layer in the distillate after the addition of penicillin G potassium salt to n-butyl acetate (values in parentheses), as well as the moisture content of the evaporated residue. All experiments yielded white penicillin G potassium crystals in high yields (defined as 100% relative to the penicillin content in the activated charcoal-treated extract) with limited loss of penicillin from the mother liquor. The penicillin G potassium content of the crystals obtained in Experiment 1 was 99.3%, indicating excellent quality of the crystals.
References
[1] Patent: WO2007/63107, 2007, A1. Location in patent: Page/Page column 7-8
[2] Patent: WO2007/63107, 2007, A1. Location in patent: Page/Page column 7
Penicillin G potassium salt Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Zhongxin Chemtech Co., Ltd. | 86-22-66880623 +8618622897568 | sales@tjzxchem.com | China | 572 | 58 |
| Jiangsu Boquan Biotechnology Co., Ltd. | +86-18168774353 | boquanshengwu003@boquansw.com | China | 248 | 58 |
| Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 | sales@suikangpharm.com | China | 311 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8772 | 58 |
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 | sales@sichuanzyyt.com | China | 12247 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 5997 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1014 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
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- Mar 11，2025
View Lastest Price from Penicillin G potassium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-18 | Penicillin G potassium
113-98-4
|
US $39.00 / g | 98.55% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-10-18 | Potassium benzylpenicillin
113-98-4
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-10-17 | Potassium benzylpenicillin
113-98-4
|
US $1.00 / KG | 1KG | ≥96.0% | 1000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Penicillin G potassium
113-98-4
- US $39.00 / g
- 98.55%
- TargetMol Chemicals Inc.
-
- Potassium benzylpenicillin
113-98-4
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Potassium benzylpenicillin
113-98-4
- US $1.00 / KG
- ≥96.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
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