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ChemicalBook >> CAS DataBase List >>Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Structure
Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- structure
CAS No.
2628506-54-5
Chemical Name:
Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-
Synonyms
PD-1/PD-L1-IN-9;PD1/PDL1IN9,PD 1/PD L1 IN 9;PD-1/PD-L1-IN-9, 10 mM in DMSO;Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-
CBNumber:
CB49280489
Molecular Formula:
C22H24N2O2
Molecular Weight:
348.44
MDL Number:
MOL File:
2628506-54-5.mol
Last updated:2025-09-20 20:09:13
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Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Properties

Boiling point 498.5±45.0 °C(Predicted)
Density 1.127±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (286.99 mM; Need ultrasonic)
form Solid
pka 14.68±0.10(Predicted)
color White to off-white

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Chemical Properties,Uses,Production

Uses

PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model[1].

Biological Activity

PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model[1]. PD-1/PD-L1-IN-9 (compound 24) (46.9-1500 nM; pretreated for 2 h) dose-dependently significantly activates the antitumor immunity of PBMCs to MDB-MB 231 cells, with an EC50 of ～100 nM[1]. PD-1/PD-L1-IN-9 (compound 24) (40-80 mg/kg; p.o. once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner and does not cause any body weight loss or mortality of mice[1].PD-1/PD-L1-IN-9 (3 mg/kg; a single i.v.) exhibits half-life (t1/2=4.2 h), plasma clearance (Cl=11.5 L/h/kg) and Cmax (1233 ng/mL) in rats[1].PD-1/PD-L1-IN-9 (25 mg/kg; a single p.o.) exhibits moderate oral bioavailability (F=22 %), half-life (t1/2=6.4 h) and Cmax (192 ng/mL) in rats[1].

in vivo

PD-1/PD-L1-IN-9 (compound 24) (40-80 mg/kg; p.o.; once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner and does not cause any body weight loss or mortality of mice[1].
PD-1/PD-L1-IN-9 (3 mg/kg; i.v.; single dose) exhibits half-life (T1/2=4.2 h), plasma clearance (Cl=11.5 L/h/kg) and Cmax (1233 ng/mL) in rats[1].
PD-1/PD-L1-IN-9 (25 mg/kg; p.o.; single dose) exhibits moderate oral bioavailability (F=22 %), half-life (t1/2=6.4 h) and Cmax (192 ng/mL) in rats[1].

Animal Model:Male BALB/c mice (5-6 weeks) were inoculated CT26 cells[1]
Dosage:40 mg/kg, 80 mg/kg
Administration:Oral gavage; once daily, for 2 weeks
Result:Significantly decreased the final tumor weight, with TGI values of 60 and 67% at the dose of 40 and 80 mg/kg, respectively.
Animal Model:Pharmacokinetic analysis in sprague-Dawley (SD) rats[1]
Dosage:3 mg/kg and 25 mg/kg
Administration:Intravenous injection or oral gavage; single dose
Result:
RouteDose (mg/kg)AUC(0-t) (ng·h/mL)Cmax (ng/mL)t1/2 (h)TmaxCl (L·h/kg)Vz (L/kg)F (%)
i.v.3430.512334.20.0311.578.6/
p.o.25787.41926.40.6928.8249.322

References

[1]. Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29545 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58
Guangzhou Lucheng Biotechnology Co., Ltd. 16620452357 CHINA 0 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Yifei Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Guangzhou Lucheng Biotechnology Co., Ltd. 58

View Lastest Price from Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PD-1/PD-L1-IN-9 pictures 2025-09-19 PD-1/PD-L1-IN-9
2628506-54-5
 US $55.00-136.00 / mg 99.92% 10g TargetMol Chemicals Inc.
  • PD-1/PD-L1-IN-9 pictures
  • PD-1/PD-L1-IN-9
    2628506-54-5
  • US $55.00-136.00 / mg
  • 99.92%
  • TargetMol Chemicals Inc.

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- Spectrum

Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]-(2628506-54-5)1HNMR
Ethanol, 2-[[[2-methoxy-6-(2-methyl[1,1'-biphenyl]-3-yl)-3-pyridinyl]methyl]amino]- PD-1/PD-L1-IN-9 PD1/PDL1IN9,PD 1/PD L1 IN 9 PD-1/PD-L1-IN-9, 10 mM in DMSO 2628506-54-5