NOTUMib-1
- CAS No.
- Chemical Name:
- NOTUMib-1
- Synonyms
- NOTUMib-1
- CBNumber:
- CB49398528
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
NOTUMib-1 Chemical Properties, Uses, Production
Description
NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling.1NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 μM, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity.2NOTUM inhibitors have potential as new therapeutics for degenerative diseases.3
Uses
NOTUMib-1 is a NOTUM inhibitor. NOTUM inhibitors have potentials as new therapeutics for degenerative diseases.
References
[1] XINJUN ZHANG Xi H. Methods for Studying Wnt Protein Modifications/Inactivations by Extracellular Enzymes, Tiki and Notum.[J]. Methods in molecular biology, 2016, 1481: 29-38. DOI:10.1007/978-1-4939-6393-5\_4
[2] BENJAMIN N ATKINSON. Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.[J]. MedChemComm, 2019, 10 8: 1361-1369. DOI:10.1039/c9md00096h
[3] RADU M. SUCIU. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling[J]. ACS Medicinal Chemistry Letters, 2018, 9 6: 563-568. DOI:10.1021/acsmedchemlett.8b00191
NOTUMib-1 Preparation Products And Raw materials
Raw materials
Preparation Products
NOTUMib-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Focus Biomolecules | -- | sales@focusbiomolecules.com | United States | 1282 | 58 |
| Supplier | Advantage |
|---|---|
| Focus Biomolecules | 58 |
