5-Bromoacetyl-2-hydroxybenzaldehyde
- CAS No.
- 115787-50-3
- Chemical Name:
- 5-Bromoacetyl-2-hydroxybenzaldehyde
- Synonyms
- Salbutamol Impurity 29;Salbutamol Impurity 18;Salbutamol Impurity 134;Levalbuterol Impurity 13;Salbutamol EP Impurity 20;5-(Bromoacetyl)salicylaldehyde;5-bromoacetyl-3-hydroxybenzaldehyde;5-Bromoacetyl-2-hydroxybenzaldehyde;Benzaldehyde,5-(2-broMoacetyl)-2-hydroxy-;5-Bromoacetyl-2-hydroxybenzaldehyde ISO 9001：2015 REACH
- CBNumber:
- CB4946876
- Molecular Formula:
- C9H7BrO3
- Molecular Weight:
- 243.05
- MDL Number:
- MFCD09833486
- MOL File:
- 115787-50-3.mol
| Product description | Number | Pack Size | Price |
| 5-(Bromoacetyl)salicylaldehyde | B679340 | 1g | $110 |
| 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde | FB151380 | 5mg | $117 |
| 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde | FB151380 | 10mg | $203 |
| 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde | FB151380 | 25mg | $405 |
| 5-BROMOACETYL-2-HYDROXYBENZALDEHYDE 95.00% | HCH0359386 | 5MG | $500.56 |
| More product size | |||
| Melting point | 117-118 °C(Solv: dichloromethane (75-09-2)) |
|---|---|
| Boiling point | 368.3±32.0 °C(Predicted) |
| Density | 1.685±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 5.93±0.20(Predicted) |
| color | Yellow to Dark Yellow |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C9H7BrO3/c10-4-9(13)6-1-2-8(12)7(3-6)5-11/h1-3,5,12H,4H2 |
| InChIKey | LPSGRBXPXIPMPF-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC(C(CBr)=O)=CC=C1O |
5-Bromoacetyl-2-hydroxybenzaldehyde price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B679340 | 5-(Bromoacetyl)salicylaldehyde | 115787-50-3 | 1g | $110 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB151380 | 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde | 115787-50-3 | 5mg | $117 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB151380 | 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde | 115787-50-3 | 10mg | $203 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB151380 | 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde | 115787-50-3 | 25mg | $405 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0359386 | 5-BROMOACETYL-2-HYDROXYBENZALDEHYDE 95.00% | 115787-50-3 | 5MG | $500.56 | 2021-12-16 | Buy |
5-Bromoacetyl-2-hydroxybenzaldehyde Chemical Properties,Uses,Production
Chemical Properties
Brown Solid
Uses
Intermediate in the preparation of Salmeterol (S090100).
Synthesis
90-02-8
598-21-0
115787-50-3
To a suspension of aluminum chloride (4 mole equivalents) in dichloromethane (10 volumes), bromoacetyl bromide (1.2 mole equivalents) was added slowly and dropwise at 100 °C, and the temperature of the reaction system was subsequently adjusted to 30 °C. The reaction mixture was stirred continuously for 1 hour, and then 2-hydroxybenzaldehyde (1 mole equivalent) was added dropwise in dichloromethane. The reaction mixture was stirred continuously at this temperature for 1 h. Then a dichloromethane solution of 2-hydroxybenzaldehyde (1 mole equivalent) was added dropwise. The reaction mixture was stirred at 35-40 °C for 12-15 hours, followed by quenching the reaction with water at 0-50 °C. The organic layer (dichloromethane layer) was separated and the solvent was removed by distillation. To the residue n-heptane was added and stirred for 15 minutes. The resulting slurry was filtered and the wet filter cake was washed with n-heptane (2 vol). The wet filter cake was dried to constant weight at 50 °C to give the intermediate 5-bromoacetyl-2-hydroxybenzaldehyde (2a). Yield: 55% (w/w); HPLC purity: 97-99
References
[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 13, p. 4194 - 4198
[2] Angew. Chem., 2016, vol. 128, # 13, p. 4266 - 4270,5
[3] Tetrahedron Asymmetry, 2008, vol. 19, # 15, p. 1824 - 1828
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1548 - 1552
[5] Chemical Communications, 2018, vol. 54, # 25, p. 3106 - 3109
5-Bromoacetyl-2-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3681 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13800 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21595 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | sales01@jndxj.com | China | 317 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
View Lastest Price from 5-Bromoacetyl-2-hydroxybenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-27 | 5-Bromoacetyl-2-hydroxybenzaldehyde
115787-50-3
|
US $1000.00 / ASSAYS | 100g | 98% Min | 1MT | Anhui Dexinjia Biopharm Co., Ltd | |
 |
2026-02-27 | 5-Bromoacetyl-2-hydroxybenzaldehyde
115787-50-3
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-01-23 | Levalbuterol Impurity 13
115787-50-3
|
US $0.00-0.00 / mg | 10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- 5-Bromoacetyl-2-hydroxybenzaldehyde
115787-50-3
- US $1000.00 / ASSAYS
- 98% Min
- Anhui Dexinjia Biopharm Co., Ltd
-
- 5-Bromoacetyl-2-hydroxybenzaldehyde
115787-50-3
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Levalbuterol Impurity 13
115787-50-3
- US $0.00-0.00 / mg
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
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