rotundine
- CAS No.
- 483-14-7
- Chemical Name:
- rotundine
- Synonyms
- Hyndarine;Gindarine;(-)-Gindarine;ROTUNDINE 98+%;ROTUNDINE (RG);Rotundine?, BR;(S)-Tetrahydrop;Rafoxanide Impurity 3;(S)-Tetrahydropalmitine;Rotundine, 10 mM in DMSO
- CBNumber:
- CB4947141
- Molecular Formula:
- C21H25NO4
- Molecular Weight:
- 355.43
- MDL Number:
- MFCD03265591
- MOL File:
- 483-14-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| L-Tetrahydropalmatine >98.0%(HPLC) | T3311 | 250mg | $80 |
| L-Tetrahydropalmatine ≥98% | 20535 | 25mg | $36 |
| L-Tetrahydropalmatine ≥98% | 20535 | 50mg | $53 |
| L-Tetrahydropalmatine ≥98% | 20535 | 100mg | $70 |
| L-Tetrahydropalmatine ≥98% | 20535 | 250mg | $86 |
| More product size | |||
| Melting point | 141-143°C |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | insoluble in H2O; ≥16 mg/mL in DMSO; ≥2.95 mg/mL in EtOH with gentle warming and ultrasonic |
| pka | 6.53±0.20(Predicted) |
| Boiling point | 482.9±45.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| λmax | 280nm(lit.) |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING - MISCELLANEOUS HAIR CONDITIONING |
| InChI | 1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1 |
| InChIKey | AEQDJSLRWYMAQI-KRWDZBQOSA-N |
| SMILES | COC1=CC=C2C(CN(CCC3=C4C=C(OC)C(OC)=C3)[C@@]4([H])C2)=C1OC |
| CAS DataBase Reference | 483-14-7 |
| FDA UNII | 3X69CO5I79 |
| UNSPSC Code | 12352205 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H227 | |||||||||
| Precautionary statements | P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| RTECS | HQ1792500 | |||||||||
| HS Code | 2933.99.9000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
rotundine price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T3311 | L-Tetrahydropalmatine >98.0%(HPLC) | 483-14-7 | 250mg | $80 | 2026-04-30 | Buy |
| Cayman Chemical | 20535 | L-Tetrahydropalmatine ≥98% | 483-14-7 | 25mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 20535 | L-Tetrahydropalmatine ≥98% | 483-14-7 | 50mg | $53 | 2026-04-30 | Buy |
| Cayman Chemical | 20535 | L-Tetrahydropalmatine ≥98% | 483-14-7 | 100mg | $70 | 2026-04-30 | Buy |
| Cayman Chemical | 20535 | L-Tetrahydropalmatine ≥98% | 483-14-7 | 250mg | $86 | 2026-04-30 | Buy |
rotundine Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Rotundine is an analgesic drug found in Chinese herbal medicine, used to treat heart disease and liver damage.
Definition
ChEBI: A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.
Biological Activity
levo-tetrahydropalmatine (l-thp) is an active herbal constituent of preparations containing plant species of the genera stephania and corydalis. in china, it has been approved and used for a number of clinical indications under the drug name rotundine.
in vitro
in contrast to other thpb derivatives, l-thp is an antagonist at both of d1 and d2 receptors. the ki values for l-thp at d1 and d2 dopamine receptors are approximately 124 nm (d1) and 388 nm (d2), while the ic50 values are 166 nm and 1.4 μm for d1 and d2, respectively. the relatively high affinity of l-thp at d1 vs. d2 receptors, distinguishes it from other available dopamine receptor antagonist drugs (e.g., haloperidol) [1].
in vivo
it has been found that l-thp produces dose-dependent reductions in locomotor activity and operant responding for non-drug reinforcers in rats [1].
References
[1] wang jb, mantsch jr. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. future med chem. 2012 feb;4(2):177-86.
rotundine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29793 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 10000 | 58 |
View Lastest Price from rotundine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Rotundine
483-14-7
|
US $31.00-98.00 / mg | 99.91% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | L-Tetrahydropalmatine
483-14-7
|
US $0.00 / mg | 5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2022-02-19 | L-Tetrahydropalmatine
483-14-7
|
US $0.00 / KG | 1KG | 99.5% | 100 tons | Honest Joy Holdings Limited |
-
- Rotundine
483-14-7
- US $31.00-98.00 / mg
- 99.91%
- TargetMol Chemicals Inc.
-
- L-Tetrahydropalmatine
483-14-7
- US $0.00 / mg
- Analytical Standard
- Shanghai Standard Technology Co., Ltd.
-
- L-Tetrahydropalmatine
483-14-7
- US $0.00 / KG
- 99.5%
- Honest Joy Holdings Limited
