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3-Fluoro-4-(4-methylpiperazin-1-yl)aniline

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Structure
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline structure
CAS No.
221198-99-8
Chemical Name:
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
Synonyms
3-fluoro-4-(4-methyl-1-pi...;3-Fluoro-4-(4-Methyl-1-piperazinyl)aniline;3-Fluoro-4-(4-methylpiperazin-1-yl)aniline;1-(4-Amino-2-fluorophenyl)-4-methylpiperazine;3-fluoro-4-(4-Methyl-1-piperazinyl)benzenaMine;3-Fluoro-4-(4-methylpiperazin-1-yl)phenylamine;Benzenamine, 3-fluoro-4-(4-methyl-1-piperazinyl)-;[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine dihydrochloride
CBNumber:
CB4956516
Molecular Formula:
C11H16FN3
Molecular Weight:
209.26
MDL Number:
MFCD05663793
MOL File:
221198-99-8.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Properties

Melting point 87-89
Boiling point 349.5±42.0 °C(Predicted)
Density 1.167±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 7.56±0.42(Predicted)
Appearance Light brown to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P321
HazardClass  IRRITANT
HS Code  2921420090

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS21004 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline 98% 221198-99-8 5g $22 2026-06-04 Buy
Activate Scientific AS21004 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline 98% 221198-99-8 25g $73 2026-06-04 Buy
Activate Scientific AS21004 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline 98% 221198-99-8 100g $188 2026-06-04 Buy
Matrix Scientific 045112 3-Fluoro-4-(4-methylpiperazino)aniline 221198-99-8 25.00g $67 2026-05-18 Buy
Matrix Scientific 045112 3-Fluoro-4-(4-methylpiperazino)aniline 221198-99-8 100.00g $265 2026-05-18 Buy
Product number Packaging Price Buy
AS21004 5g $22 Buy
AS21004 25g $73 Buy
AS21004 100g $188 Buy
045112 25.00g $67 Buy
045112 100.00g $265 Buy

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Chemical Properties, Uses, Production

Uses

3-Fluoro-4-(4-methylpiperazinyl)aniline can be used as a pharmaceutical synthesis intermediate.

Synthesis

1-(2-FLUORO-4-NITROPHENYL)-4-METHYLPIPERAZINE

221198-29-4

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline

221198-99-8

General procedure: 1-(2-fluoro-4-nitrophenyl)-4-methylpiperazine (14.76 g, 61.70 mmol) was dissolved in tetrahydrofuran (THF, 80 mL) and palladium/carbon catalyst (Pd/C, 3.00 g) was added. Hydrogen (H2) was passed into the reaction mixture at room temperature and the reaction was stirred overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 3-fluoro-4-(4-methylpiperazinyl)aniline as an off-white solid (11.99 g, 93% yield).

References

[1] Patent: US2002/151554, 2002, A1
[2] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00293
[3] Patent: US2015/87639, 2015, A1. Location in patent: Paragraph 0550
[4] Patent: TWI607995, 2017, B. Location in patent: Page/Page column 128
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3507 - 3525

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Preparation Products And Raw materials

Raw materials

1-(2-Fluoro-4-nitrophenyl)-4-methylpiperazine Hydrogen Palladium Tetrahydrofuran

Preparation Products

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Suppliers

Global Suppliers ( 93)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2283 55
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9513 58
Shanghai Yolne Chemical Co., Ltd. 021-62960152 934678158@qq.com China 9886 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Accela ChemBio Co.,Ltd. 64
Shanghai Ennopharm Co., Ltd. 65
Nanjing Vital Chemical Co., Ltd. 65
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Yolne Chemical Co., Ltd. 55

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View Latest Price from 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline pictures 2026-07-27 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
221198-99-8
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
3-Fluoro-4-(4-methylpiperazin-1-yl)aniline pictures 2019-12-26 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
221198-99-8
 $1.00 1KG 99% 100KG Career Henan Chemical Co

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline Spectrum

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline(221198-99-8)1HNMR

221198-99-8 (3-Fluoro-4-(4-methylpiperazin-1-yl)aniline) Related Search:

eperezolid N-[3-Fluoro-4-(4-methylpiperazino)phenyl]-2-[(4-methoxyphenyl)sulfanyl]acetamide 2-[(4-Chlorophenyl)sulfanyl]-N-[3-fluoro-4-(4-phenylpiperazino)phenyl]acetamide N-[3-Fluoro-4-(4-phenylpiperazino)phenyl]-2-(phenylsulfanyl)acetamide 2-[(4-Chlorophenyl)sulfanyl]-N-[3-fluoro-4-(4-methylpiperazino)phenyl]acetamide
N-[3-Fluoro-4-(4-phenylpiperazino)phenyl]-2-[(4-methoxyphenyl)sulfanyl]acetamide 4-Chloro-N-[3-fluoro-4-(4-phenylpiperazino)phenyl]benzenecarboxamide 3-Fluoro-4-(4-phenylpiperazino)aniline N-[3-Fluoro-4-(4-phenylpiperazino)phenyl]-3-methylbenzenecarboxamide N-[3-Fluoro-4-(4-phenylpiperazino)phenyl]-4-methylbenzenecarboxamide
N-[3-Fluoro-4-(4-methylpiperazino)phenyl]-3-methylbenzenecarboxamide 4-Fluoro-N-[3-fluoro-4-(4-phenylpiperazino)phenyl]benzenecarboxamide N-[3-Fluoro-4-(4-phenylpiperazino)phenyl]cyclopropanecarboxamide 2-[(2,4-Dimethylphenyl)sulfanyl]-N-[3-fluoro-4-(4-methylpiperazino)phenyl]acetamide N-[3-Fluoro-4-(4-methylpiperazino)phenyl]cyclopropanecarboxamide
N-[3-Fluoro-4-(4-phenylpiperazino)phenyl]-2-phenylacetamide N-[3-Fluoro-4-(4-phenylpiperazino)phenyl]-4-methoxybenzenecarboxamide

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3-Fluoro-4-(4-methylpiperazin-1-yl)aniline 3-Fluoro-4-(4-methylpiperazin-1-yl)phenylamine 3-fluoro-4-(4-methyl-1-pi... 3-fluoro-4-(4-Methyl-1-piperazinyl)benzenaMine 3-Fluoro-4-(4-Methyl-1-piperazinyl)aniline [3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine dihydrochloride 1-(4-Amino-2-fluorophenyl)-4-methylpiperazine Benzenamine, 3-fluoro-4-(4-methyl-1-piperazinyl)- 221198-99-8 C11H16FN3