3-Aminopyridine-2-carboxylic acid ethyl ester
- CAS No.
- 27507-15-9
- Chemical Name:
- 3-Aminopyridine-2-carboxylic acid ethyl ester
- Synonyms
- Ethyl 3-AMinopicolinate;3-Aminopicolinic acid ethyl ester;Ethyl 3-Aminopyridine-2-carboxylate;Picolinic acid, 3-amino-, ethyl ester;3-Aminopyridine-2-carboxylic acid ethyl ester;3-AMino-2-pyridinecarboxylic Acid Ethyl Ester;2-Pyridinecarboxylic acid, 3-aMino-, ethyl ester;3-Aminopyridine-2-carboxylic acid ethyl ester ISO 9001：2015 REACH
- CBNumber:
- CB4967400
- Molecular Formula:
- C8H10N2O2
- Molecular Weight:
- 166.18
- MDL Number:
- MFCD00661294
- MOL File:
- 27507-15-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl3-Aminopyridine-2-carboxylate | E705505 | 100mg | $45 |
| Ethyl 3-aminopicolinate 95+% | 119584 | 1g | $48 |
| 3-Aminopyridine-2-carboxylicacidethylester 98% | OR951533 | 1g | $90 |
| Ethyl3-aminopicolinate | Z4538 | 1g | $91 |
| Ethyl 3-aminopicolinate 95+% | 119584 | 5g | $132 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 |
| HS Code | 2933399990 |
3-Aminopyridine-2-carboxylic acid ethyl ester price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E705505 | Ethyl3-Aminopyridine-2-carboxylate | 27507-15-9 | 100mg | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 119584 | Ethyl 3-aminopicolinate 95+% | 27507-15-9 | 1g | $48 | 2021-12-16 | Buy |
| Apolloscientific | OR951533 | 3-Aminopyridine-2-carboxylicacidethylester 98% | 27507-15-9 | 1g | $90 | 2021-12-16 | Buy |
| AK Scientific | Z4538 | Ethyl3-aminopicolinate | 27507-15-9 | 1g | $91 | 2021-12-16 | Buy |
| Matrix Scientific | 119584 | Ethyl 3-aminopicolinate 95+% | 27507-15-9 | 5g | $132 | 2021-12-16 | Buy |
3-Aminopyridine-2-carboxylic acid ethyl ester Chemical Properties,Uses,Production
Uses
A synthetic intermediate for the synthesis of Kenpaullone derivatives, Cannabinoid receptor ligands, and nociceptive agents.
Synthesis
64-17-5
1462-86-8
27507-15-9
3-Aminopyridine-2-carboxylic acid (28 g, 200 mmol, 1.0 eq.) was suspended in ethanol (800 mL) at room temperature and bubbled through hydrogen chloride gas (HCl(g)) for 10 min, and the reaction mixture was transformed into a clarified yellow solution. The reaction mixture was heated to 100 °C and after stirring the reaction for 1 day, LCMS analysis showed that about 50% of the feedstock was unreacted. The reaction mixture was cooled to room temperature, bubbled again with hydrogen chloride gas (HCl(g)) for 10 minutes, and then reheated to 100 °C. The reaction mixture was then stirred for 1 day and the LCMS analysis showed that about 50% of the feedstock was unreacted. After continuing to stir the reaction for 1 day, LCMS analysis still showed that about 50% of the feedstock was unreacted. The reaction mixture was cooled to room temperature and concentrated under reduced pressure to remove all solvent. The residue was resuspended in ethanol (800 mL) and bubbled through hydrogen chloride gas (HCl(g)) for 10 minutes. The resulting mixture was reacted at reflux in an oil bath at 100 °C for 1 day.LCMS analysis showed a conversion of about 70-75%. The reaction mixture was cooled to room temperature and concentrated under reduced pressure to remove all solvents. The solid residue was dissolved in water (250 mL) and the pH was adjusted to 8-9 with saturated aqueous sodium carbonate (Na2CO3) for bursting. Gas production and formation of a white solid was observed. The suspension was filtered, the solid was washed with water and dried under vacuum at 65 °C to give ethyl 3-aminopyridine-2-carboxylate (22 g, 65% yield) as a white solid.LCMS (APCI, M++1) 167.0; 1H NMR (300 MHz, DMSO-d6) δ ppm 7.84 (dd, J=4.05,1.60 Hz, 1H), and 7.23-7.30 (m, 1H), 7.16-7.23 (m, 1H), 6.65 (br.s., 2H), 4.27 (q, J=7.10 Hz, 2H), 1.30 (t, J=7.06 Hz, 3H).
References
[1] Journal of Organic Chemistry, 2004, vol. 69, # 1, p. 54 - 61
[2] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 55
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 7, p. 2196 - 2207
[4] Journal of the Chemical Society, 1949, p. 3304,3310
[5] Journal of the Chemical Society, 1956, p. 1045,1053
3-Aminopyridine-2-carboxylic acid ethyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| JIAXING REGEN CHEMICAL CO.,LTD | +8613385739570 | regen_chemical1@163.com | China | 226 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14360 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8026 | 58 |
View Lastest Price from 3-Aminopyridine-2-carboxylic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-06-25 | 3-Aminopyridine-2-carboxylic acid ethyl ester
27507-15-9
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-02-05 | 3-Aminopyridine-2-carboxylic acid ethyl ester
27507-15-9
|
US $3.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 3-Aminopyridine-2-carboxylic acid ethyl ester
27507-15-9
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Aminopyridine-2-carboxylic acid ethyl ester
27507-15-9
- US $3.00 / KG
- 98%
- Career Henan Chemical Co
