Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>(R)-(-)-1-Methyl-3-pyrrolidinol

(R)-(-)-1-Methyl-3-pyrrolidinol

(R)-(-)-1-Methyl-3-pyrrolidinol Structure
(R)-(-)-1-Methyl-3-pyrrolidinol structure
CAS No.
104641-60-3
Chemical Name:
(R)-(-)-1-Methyl-3-pyrrolidinol
Synonyms
(R)-1-METHYLPYRROLIDIN-3-OL;(R)-1-METHYL-3-PYRROLIDINOL;UNII:CGW2AL7PQ7;Glycopyrrolate Impurity 9;Glycopyrrolate Impurity 22;(R)-N-Methyl-3-pyrrolidinol;(3R)-1-Methylpyrrolidin-3-ol;(S)-3-Hydroxy-1-methylpyr...;(3R)-1-Methyl-3-pyrrolidinol;-(-)-1-Methyl-3-pyrrolidinol
CBNumber:
CB5104299
Molecular Formula:
C5H11NO
Molecular Weight:
101.15
MDL Number:
MFCD03788747
MOL File:
104641-60-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:38
Product description Number Pack Size Price
(R)-(?)-1-Methyl-3-pyrrolidinol 97% 647241 1g $134
(R)-1-Methyl-3-pyrrolidinol >98.0%(GC) M1937 1g $74
(R)-1-Methyl-3-pyrrolidinol >98.0%(GC) M1937 5g $252
(R)-3-HYDROXY-1-METHYL-PYRROLIDINE 95% 62206 1G $46
(R)-3-HYDROXY-1-METHYL-PYRROLIDINE 95% 62206 5G $139
More product size
Request For Quotation

(R)-(-)-1-Methyl-3-pyrrolidinol Properties

alpha -7 º (c=1%, chloroform)
Boiling point 50-52 °C1 mm Hg(lit.)
Density 0.921 g/mL at 25 °C(lit.)
refractive index n20/D 1.4640(lit.)
Flash point 159 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 14.95±0.20(Predicted)
form Liquid
color Colorless to yellow to brown
optical activity [α]20/D -7°, c = 1% in chloroform
Sensitive Air Sensitive & Hygroscopic
BRN 4349393
InChIKey FLVFPAIGVBQGET-RXMQYKEDSA-N
CAS DataBase Reference 104641-60-3(CAS DataBase Reference)
FDA UNII 6HVW4EW50X

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H227-H315-H319-H335
Precautionary statements  P210e-P280a-P501a-P261-P305+P351+P338-P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  NA 1993 / PGIII
WGK Germany  3
HS Code  29339900
NFPA 704
2
2 1

(R)-(-)-1-Methyl-3-pyrrolidinol price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 647241 (R)-(?)-1-Methyl-3-pyrrolidinol 97% 104641-60-3 1g $134 2023-06-20 Buy
TCI Chemical M1937 (R)-1-Methyl-3-pyrrolidinol >98.0%(GC) 104641-60-3 1g $74 2026-04-30 Buy
TCI Chemical M1937 (R)-1-Methyl-3-pyrrolidinol >98.0%(GC) 104641-60-3 5g $252 2026-04-30 Buy
AstaTech 62206 (R)-3-HYDROXY-1-METHYL-PYRROLIDINE 95% 104641-60-3 1G $46 2026-04-30 Buy
AstaTech 62206 (R)-3-HYDROXY-1-METHYL-PYRROLIDINE 95% 104641-60-3 5G $139 2026-04-30 Buy
Product number Packaging Price Buy
647241 1g $134 Buy
M1937 1g $74 Buy
M1937 5g $252 Buy
62206 1G $46 Buy
62206 5G $139 Buy

(R)-(-)-1-Methyl-3-pyrrolidinol Chemical Properties,Uses,Production

Chemical Properties

Brown liquid

Uses

(R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.

Synthesis

Formaldehyde

50-00-0

3-Pyrrolidinol

40499-83-0

(R)-(-)-1-Methyl-3-pyrrolidinol

104641-60-3

In a 100 mL round bottom flask, 2 g of (R)-3-hydroxypyrrolidine, 25 mL of tetrahydrofuran (THF), 0.49 g of paraformaldehyde, and 1.5 g of 90% formic acid were added sequentially. The reaction mixture was stirred under reflux conditions for 5 h (until all solids were completely dissolved), after which the reaction system was cooled to 0 °C and the pH was adjusted to about 10 by slow addition of 10 mL of 10 N sodium hydroxide solution. the organic phase was separated and dried over anhydrous magnesium sulfate. After filtration to remove the desiccant, the solvent (THF) was removed by distillation under reduced pressure to afford the oily product (R)-1-methyl-3-hydroxypyrrolidine (1.5 g, 92% yield). The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 1.50-1.60 (m, 1H), 1.98-2.10 (m, 1H), 2.25 (s, 3H), 2.25-2.40 (m, 2H), 2.50-2.60 (m, 1H), 2.61-2.70 (m, 1H), 3.80 (brs, 1H), and 4.20-4.30 (m, 1H).

References

[1] Patent: US2007/123557, 2007, A1. Location in patent: Page/Page column 16
[2] Patent: WO2003/87094, 2003, A2. Location in patent: Page/Page column 34

(R)-(-)-1-Methyl-3-pyrrolidinol Preparation Products And Raw materials

Raw materials

Formaldehyde 3-Pyrrolidinol (R)-(-)-3-Pyrrolidinol hydrochloride Tetrahydrofuran Formic acid

Preparation Products

(R)-(-)-1-Methyl-3-pyrrolidinol Suppliers

Global( 210)Suppliers
Supplier Tel Email Country ProdList Advantage
Ningbo Polysyn Pharmatech Co.,Ltd
+8615706225626 BD@polysyn.cn China 86 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13843 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82375818 +86-15064153060 sales01@jndxj.com China 298 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
BTC Nantong Pharmaceuticals Technology Co.,Ltd 		+86-0513-81283365 Info@btcpharm.com China 251 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Supplier Advantage
Ningbo Polysyn Pharmatech Co.,Ltd
58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
career henan chemical co 		58
Anhui Dexinjia Biopharm Co., Ltd 		58
Accela ChemBio Inc. 		58
BTC Nantong Pharmaceuticals Technology Co.,Ltd 		58
Standardpharm Co. Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from (R)-(-)-1-Methyl-3-pyrrolidinol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-1-Methyl-3-pyrrolidinol pictures 2026-04-21 (R)-1-Methyl-3-pyrrolidinol
104641-60-3
 US $200.00-4000.00 / KG 100KG no less than 98% 1MT per month Anhui Dexinjia Biopharm Co., Ltd
(R)-(-)-1-Methyl-3-pyrrolidinol pictures 2025-06-03 (R)-(-)-1-Methyl-3-pyrrolidinol
104641-60-3
 US $90.00-900.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
(R)-(-)-1-Methyl-3-pyrrolidinol pictures 2024-02-26 (R)-(-)-1-Methyl-3-pyrrolidinol
104641-60-3
 US $0.00-0.00 / kg 1kg 98% Kgs BTC Nantong Pharmaceuticals Technology Co.,Ltd

(R)-(-)-1-Methyl-3-pyrrolidinol Spectrum

(R)-(-)-1-Methyl-3-pyrrolidinol(104641-60-3)MS(R)-(-)-1-Methyl-3-pyrrolidinol(104641-60-3)1HNMR(R)-(-)-1-Methyl-3-pyrrolidinol(104641-60-3)13CNMR

104641-60-3((R)-(-)-1-Methyl-3-pyrrolidinol)Related Search:

3-Pyrrolidinol CHLOROPHOSPHONAZO III Pirimiphos-methyl 1-Methylpyrrolidine 2,5-Dimethylpyrrolidine
Kresoxim-methyl N-Methyl-2-pyrrolidone Pyrrolidine Tribenuron methyl Methyl acetate
METSULFURON METHYL Methyl salicylate (S)-1-METHYL-3-PYRROLIDINOL Thiophanate-methyl Polyvinylpyrrolidone
Methyl Benzoylformic acid LPHE-009

1of4

(3R)-1-Methylpyrrolidin-3-ol (R)-N-Methyl-3-pyrrolidinol 3-Pyrrolidinol,1-methyl-, (3R)- (R)-N-Methyl-3-pyrrolidinol,99%e.e. (R)-(-)-1-METHYL-3-PYRROLIDINOL (R)-1-METHYL-3-PYRROLIDINOL (R)-(-)-1-METHYL-3-HYDROXYPYRROLIDINE (R)-3-HYDROXY-N-METHYLPYRROLIDINE (R)-(-)-Methyl-3-pyrrolidinol (R)-3-HYDROXY-1-METHYL-PYRROLIDINE (R)-(-)-1-Methyl-3-pyrrolidino (R)-(-)-1-METHYL-3-HYDROXYPYRROLIDINE, 99%, EE 99% (S)-3-Hydroxy-1-methylpyr... Glycopyrrolate Impurity 9 (R)-1-Methylpyrrolidin-3-ol 98% Glycopyrrolate Impurity 22 (R)-1-Methyl-3-pyrrolidinol> (3R)-1-Methyl-3-pyrrolidinol -(-)-1-Methyl-3-pyrrolidinol UNII:CGW2AL7PQ7 (R)-(?)-1-Methyl-3-pyrrolidinol (R-HNMP) NMDP =1-Methylpyrrolidin-3-ol Purity:98% (1.5 Kg X 4 batches) (R)-1-METHYLPYRROLIDIN-3-OL 104641-60-3 Chiral Building Blocks Asymmetric Synthesis Heterocyclic Building Blocks Pyrrolidines Pyrrole&Pyrrolidine&Pyrroline Chiral Building Blocks Simple Alcohols (Chiral) Synthetic Organic Chemistry