Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI)
- CAS No.
- 677777-45-6
- Chemical Name:
- Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI)
- Synonyms
- 4-Cyano-3-methoxybenzene boronic acid;4-Cyano-3-methoxyphenylboronic acid 97%;Boronic acid, B-(4-cyano-3-methoxyphenyl)-;4-Cyano-3-Methoxyphenylboronic Acid(WX650131);Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI);(4-Cyano-3-methoxyphenyl)boronic acid (contains varying amounts of Anhydride)
- CBNumber:
- CB51060563
- Molecular Formula:
- C8H8BNO3
- Molecular Weight:
- 176.96
- MDL Number:
- MFCD10696655
- MOL File:
- 677777-45-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (4-Cyano-3-methoxyphenyl)boronic acid 97% | AS44260 | 1g | $72 |
| (4-Cyano-3-methoxyphenyl)boronic acid 97% | AS44260 | 5g | $314 |
| (4-Cyano-3-methoxyphenyl)boronic acid 97% | AS44260 | 25g | $1062 |
| 4-Cyano-3-methoxyphenylboronic acid 97% | OR360261 | 250mg | $81 |
| (4-Cyano-3-methoxyphenyl)boronic acid | 126624 | 1.00g | $576 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315-H302+H312+H332 |
| Precautionary statements | P280-P301+P312-P362+P364 |
| RIDADR | 3439 |
| HazardClass | 6.1 |
| PackingGroup | Ⅲ |
| HS Code | 2931900090 |
Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI) price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS44260 | (4-Cyano-3-methoxyphenyl)boronic acid 97% | 677777-45-6 | 1g | $72 | 2026-06-04 | Buy |
| Activate Scientific | AS44260 | (4-Cyano-3-methoxyphenyl)boronic acid 97% | 677777-45-6 | 5g | $314 | 2026-06-04 | Buy |
| Activate Scientific | AS44260 | (4-Cyano-3-methoxyphenyl)boronic acid 97% | 677777-45-6 | 25g | $1062 | 2026-06-04 | Buy |
| Apolloscientific | OR360261 | 4-Cyano-3-methoxyphenylboronic acid 97% | 677777-45-6 | 250mg | $81 | 2026-06-04 | Buy |
| Matrix Scientific | 126624 | (4-Cyano-3-methoxyphenyl)boronic acid | 677777-45-6 | 1.00g | $576 | 2026-05-18 | Buy |
Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI) Chemical Properties,Uses,Production
Synthesis
330793-38-9
677777-45-6
The general procedure for the synthesis of (4-cyano-3-methoxyphenyl)boronic acid from 2-methoxy-4-bromobenzonitrile was as follows: an overhead mechanical stirrer and a nitrogen inlet tube were assembled in a 1L three-necked round-bottomed flask. To the reaction flask was added 45.56 g (215 mmol) of 4-bromo-2-methoxybenzonitrile, 64 mL (277 mmol) of triisopropyl borate, and 500 mL of anhydrous THF.The reaction system was cooled to -78 °C in a dry ice/acetone bath. A n-butyllithium solution (2.5 M in hexane, 110 mL, 275 mmol) was slowly added dropwise through a constant pressure dropping funnel. After dropwise addition, the reaction was maintained at -78 °C with continued stirring for 30 min, followed by addition of 2N hydrochloric acid solution to quench the reaction. The reaction mixture was stirred at room temperature for 1 h and then poured into ice water. The aqueous phase was extracted three times with ether (Et2O). The organic phases were combined and back-extracted with 1N sodium hydroxide solution. The alkaline aqueous phase was washed with ether and acidified with concentrated hydrochloric acid to pH < 2. The acidified aqueous phase was again extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 20.77 g (55% yield) of the target product (4-cyano-3-methoxyphenyl)boronic acid as a white solid. The product was characterized by 1H NMR (500 MHz, d6-DMSO): δ 7.68 (d, J=8.0 Hz, 1H), 7.59 (s, 1H), 7.47 (d, J=8.0 Hz, 1H), 3.95 (s, 3H).
References
[1] Patent: WO2005/95400, 2005, A1. Location in patent: Page/Page column 341
Boronic acid, (4-cyano-3-methoxyphenyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Shanghai Scochem Technology Co., Ltd | +86-021-33758897 +86-13701882790 | sales@scochem.com | China | 1977 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39021 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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