16-Oxa-4,8,12-triazapentacosanoic acid, 8,24-dimethyl-4,12-bis[3-[(8-methylnonyl)oxy]-3-oxopropyl]-15-oxo-, 8-methylnonyl ester
![16-Oxa-4,8,12-triazapentacosanoic acid, 8,24-dimethyl-4,12-bis[3-[(8-methylnonyl)oxy]-3-oxopropyl]-15-oxo-, 8-methylnonyl ester Structure](CAS/20211123/GIF/2322290-93-5.gif)
- CAS No.
- 2322290-93-5
- Chemical Name:
- 16-Oxa-4,8,12-triazapentacosanoic acid, 8,24-dimethyl-4,12-bis[3-[(8-methylnonyl)oxy]-3-oxopropyl]-15-oxo-, 8-methylnonyl ester
- Synonyms
- 360Oi10;306Oi10;Tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate;Tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate;16-Oxa-4,8,12-triazapentacosanoic acid, 8,24-dimethyl-4,12-bis[3-[(8-methylnonyl)oxy]-3-oxopropyl]-15-oxo-, 8-methylnonyl ester
- CBNumber:
- CB510659624
- Molecular Formula:
- C59H115N3O8
- Molecular Weight:
- 994.56
- MDL Number:
- MOL File:
- 2322290-93-5.mol
16-Oxa-4,8,12-triazapentacosanoic acid, 8,24-dimethyl-4,12-bis[3-[(8-methylnonyl)oxy]-3-oxopropyl]-15-oxo-, 8-methylnonyl ester Properties
| Boiling point | 870.8±65.0 °C(Predicted) |
|---|---|
| Density | 0.956±0.06 g/cm3(Predicted) |
| solubility | Soluble in Ethanol, DMSO, DMF |
| form | Oil |
| pka | 9.23±0.50(Predicted) |
| color | Colorless to light yellow |
| InChIKey | BPPZRZOKGADTQE-UHFFFAOYSA-N |
| SMILES | N(CCCN(C)CCCN(CCC(=O)OCCCCCCCC(C)C)CCC(=O)OCCCCCCCC(C)C)(CCC(=O)OCCCCCCCC(C)C)CCC(=O)OCCCCCCCC(C)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
16-Oxa-4,8,12-triazapentacosanoic acid, 8,24-dimethyl-4,12-bis[3-[(8-methylnonyl)oxy]-3-oxopropyl]-15-oxo-, 8-methylnonyl ester Chemical Properties,Uses,Production
Description
306Oi10 is a novel ionizable, biodegradable lipid for delivery of short interfering RNAs via lipid nanoparticles.
Uses
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery[1][2].
in vivo
304Oi10 (0.75 mg/kg, i,v., 15 min) effectively ionizes at pH 5.0 within C57BL/6 mice and demonstrates potent mRNA delivery efficacy[2].
| Animal Model: | C57BL/6 mice |
| Dosage: | 0.75 mg/kg (LNPs carrying luciferase-encoding mRNA) |
| Administration: | Intravenous injection (i.v.), 15 min |
| Result: | Delivered luciferase in a dose-dependent manner in C57BL/6 mice, inducing luciferase expression predominantly in the liver (approximately 92%). |
References
[1] Hajj K A. Lipid Nanoparticle Systems for the Delivery of Messenger RNA. Carnegie Mellon University, 2019.
[2] Hajj KA, et al. Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH. Small. 2019 Feb;15(6):e1805097. doi: 10.1002/smll.201805097. DOI:10.1002/smll.201805097
16-Oxa-4,8,12-triazapentacosanoic acid, 8,24-dimethyl-4,12-bis[3-[(8-methylnonyl)oxy]-3-oxopropyl]-15-oxo-, 8-methylnonyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
16-Oxa-4,8,12-triazapentacosanoic acid, 8,24-dimethyl-4,12-bis[3-[(8-methylnonyl)oxy]-3-oxopropyl]-15-oxo-, 8-methylnonyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 411 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Xingji Pharmaceutical (Shanghai) Co., Ltd | 15705593425 | support@utgene.com | China | 295 | 58 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 8842 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Changyu Medical Technology Co. Ltd. | +86-13301875428 | sales@changyuhe.com | China | 311 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| Shochem(Shanghai)Co.,Ltd | +86-021-51783479 +86-13816874662 | info@shochem.com | China | 307 | 58 |
