CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE
- CAS No.
- 1250-95-9
- Chemical Name:
- CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE
- Synonyms
- cholesterol 5α,6α-epoxide;cholesteroloxide;epoxycholesterol;Cholesterolepoxide;5β-Epoxycholesterol;5,6-epoxy Cholestanol;cholesterolalpha-oxide;ALPHA-EPOXYCHOLESTEROL;5a,6a-Epoxycholesterol;-9a,11b-dimethyl-9-((R)
- CBNumber:
- CB5109966
- Molecular Formula:
- C27H46O2
- Molecular Weight:
- 402.65
- MDL Number:
- MFCD00046980
- MOL File:
- 1250-95-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Cholesterol 5α,6α-epoxide | C2773 | 50mg | $108 |
| 5α,6α-epoxy Cholestanol ≥95% | 25539 | 25mg | $41 |
| 5α,6α-epoxy Cholestanol ≥95% | 25539 | 50mg | $75 |
| 5α,6α-epoxy Cholestanol ≥95% | 25539 | 100mg | $142 |
| 5α,6α-epoxy Cholestanol ≥95% | 25539 | 250mg | $332 |
| Melting point | 147 °C |
|---|---|
| Boiling point | 464.74°C (rough estimate) |
| Density | 0.9932 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml) orin Ethanol (up to 10 mg/ml). |
| pka | 15.20±0.70(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| InChIKey | PRYIJAGAEJZDBO-ZEQHCUNVSA-N |
| SMILES | [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)[C@@]3(O4)[C@@H]4C2)([H])CC[C@@]5(C)[C@@]1([H])CC[C@]5([H])[C@]([H])(C)CCCC(C)C |
| FDA UNII | 3UQ9PF5XBD |
| UNSPSC Code | 41141804 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| RTECS | FZ6360000 |
| Storage Class | 11 - Combustible Solids |
CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C2773 | Cholesterol 5α,6α-epoxide | 1250-95-9 | 50mg | $108 | 2025-07-31 | Buy |
| Cayman Chemical | 25539 | 5α,6α-epoxy Cholestanol ≥95% | 1250-95-9 | 25mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 25539 | 5α,6α-epoxy Cholestanol ≥95% | 1250-95-9 | 50mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 25539 | 5α,6α-epoxy Cholestanol ≥95% | 1250-95-9 | 100mg | $142 | 2026-04-30 | Buy |
| Cayman Chemical | 25539 | 5α,6α-epoxy Cholestanol ≥95% | 1250-95-9 | 250mg | $332 | 2026-04-30 | Buy |
CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE Chemical Properties,Uses,Production
Description
5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol. It is a major oxysterol found in processed food1and has been implicated in atherosclerosis2,3. 5α,6α-Epoxycholesterol has been found to be an endogenous ligand for LXR (EC50= 76 nM).4
Uses
Cholesterol 5alpha,6alpha-epoxide is used in the generation of oxysterols and in the studies of the biological significance of oxysterols.
Uses
Cholesterol 5α, 6α-epoxide was incorporated in culture medium of human arterial endothelial cells to study oxysterol-induced toxicity.
Uses
5α,6α-epoxycholestanol has been used as a sterol internal standard in ultra-performance liquid chromatography–high resolution mass spectrometry (UPLC-ESI-HRMS) analysis to quantify mice brain sterols. It may be used in calibration curve generation for the quantification of phytosterols in food samples and as an internal standard for oxysterol quantification in biological samples by gas chromatography-mass spectrometry (GC-MS)
Definition
ChEBI: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol is a 3beta-hydroxy steroid, an oxysterol and an epoxy steroid. It derives from a hydride of a 5alpha-cholestane.
General Description
5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation and is a diastereoisomer of 5β,6β-epoxycholestanol (5β,6β-EC).
Biochem/physiol Actions
Cholesterol 5α, 6α-epoxide is an oxysterol, a cholesterol derivative by auto-oxidation. Oxysterols are non-genomic regulators of cholesterol homeostasis. The biological effects include protein prenylation, apoptosis, modulation of sphingolipid metabolism and platelet aggregation. Oxysterols bind to liver X receptors, modulate cholesterol efflux and decrease the uptake of cholesterol by the cells.
References
[1] GABRIELLA LEONARDUZZI Giuseppe P Barbara Sottero. Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review)[J]. Journal of Nutritional Biochemistry, 2002, 13 12: Pages 700-710. DOI:10.1016/s0955-2863(02)00222-x
[2] I BJÖRKHEM. Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia.[J]. Journal of Lipid Research, 1988, 29 8: 1031-1038.
[3] ILONA STAPRANS. The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis[J]. Molecular Nutrition & Food Research, 2005, 49 11: 1075-1082. DOI:10.1002/mnfr.200500063
[4] THOMAS J BERRODIN. Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity.[J]. ACS Applied Electronic Materials, 2010: 1046-1058. DOI:10.1124/mol.110.065193
CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3993 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40228 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24529 | 81 |
| Energy Chemical | 021-021-58432009 400-005-6266 | sales8178@energy-chemical.com | China | 44802 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28387 | 80 |
View Lastest Price from CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Cholesterol-5α,6α-epoxide
1250-95-9
|
$31.00-75.00 | 99.15% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-24 | Cholesterol-5alpha,6alpha-epoxide
1250-95-9
|
1KG | 99.0% | 10000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- Cholesterol-5α,6α-epoxide
1250-95-9
- $31.00-75.00
- 99.15%
- TargetMol Chemicals Inc.
-
- Cholesterol-5alpha,6alpha-epoxide
1250-95-9
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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