5-Methoxy -isatoic anhydride
- CAS No.
- 37795-77-0
- Chemical Name:
- 5-Methoxy -isatoic anhydride
- Synonyms
- 6-methoxy-2H-benzo[d][1,3]oxazine-2,4(1H)-dione;Nsc163035;6-methoxy-1H-3,1-benzoxazine-2,4-dione;6-Methoxy-4H-3,1-benzoxazine-2,4(1H)-dione;6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 6-methoxy-;6-methoxy-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione;6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione, 6-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione
- CBNumber:
- CB51118947
- Molecular Formula:
- C9H7NO4
- Molecular Weight:
- 193.16
- MDL Number:
- MFCD02179411
- MOL File:
- 37795-77-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2934999090 |
5-Methoxy -isatoic anhydride price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 69316 | 5-METHOXY -ISATOIC ANHYDRIDE 97% | 37795-77-0 | 1G | $38 | 2026-04-30 | Buy |
| AstaTech | 69316 | 5-METHOXY -ISATOIC ANHYDRIDE 97% | 37795-77-0 | 5G | $150 | 2026-04-30 | Buy |
| AstaTech | 69316 | 5-METHOXY -ISATOIC ANHYDRIDE 97% | 37795-77-0 | 25G | $485 | 2026-04-30 | Buy |
| Apolloscientific | OR400011 | 5-Methoxyisatoic anhydride ≥95% | 37795-77-0 | 250mg | $21 | 2026-06-04 | Buy |
| Matrix Scientific | 144574 | 6-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione | 37795-77-0 | 5.00g | $626 | 2026-05-18 | Buy |
5-Methoxy -isatoic anhydride Chemical Properties,Uses,Production
Uses
5-Methoxyisatoic Anhydride is a reagent in the preparation of 18F-labeled radiotracers for GABAA receptor PET imaging.
Synthesis
6705-03-9
37795-77-0
General procedure for the synthesis of 6-methoxy-1H-benzo[d][1,3]oxazine-2,4-dione from 2-amino-5-methoxybenzoic acid: 5-methoxy-o-toluic acid (30 g, 179 mmol) was dissolved in a mixture of water (1.2 L) and concentrated hydrochloric acid. Triphosgene (63.8 g, 215 mmol) was then added, followed by concentrated hydrochloric acid (15 mL). The reaction mixture was stirred at room temperature for 3-4 hours until the reaction was complete (monitored by thin layer chromatography on silica gel plates). Upon completion of the reaction, a white solid precipitated from the solution. The solid was collected by filtration and washed with a large amount of water (4 L). The resulting solid was dried under vacuum to afford anhydride (30.7 g) of 89% purity in the following yield: melting point 237-239 °C; 1H NMR (300 MHz, CDCl3) δ 3.65 (s, 3H), 7.11 (d, 1H, J=8.9 Hz), 7.35 (dd, 1H, J=8.9 Hz, 2.7 Hz), 7.19 (d, 1H J=2.7 Hz), 11.61 (bs, 1H). The spectral data were in agreement with the values reported in the literature [27]. The product can be used directly in the next step of the reaction without further purification. Note: Triphosgene is toxic and requires extra care when handling.
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1492 - 1500
[2] Organic Process Research and Development, 2013, vol. 17, # 8, p. 1042 - 1051
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 550 - 560
5-Methoxy -isatoic anhydride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2283 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Lastest Price from 5-Methoxy -isatoic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione
37795-77-0
|
$2.20-8.80 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-05-18 | 5-Methoxyisatoic anhydride
37795-77-0
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd |
-
- 6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione
37795-77-0
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 5-Methoxyisatoic anhydride
37795-77-0
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
