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2-Hydroxy-5-methylpyridine

2-Hydroxy-5-methylpyridine structure

CAS No.: 1003-68-5

Chemical Name:: 2-Hydroxy-5-methylpyridine

Synonyms: 5-Methylpyridin-2(1H)-one;2(1H)-Pyridinone, 5-methyl-;5-methyl-2-pyridone;2-HYDROXY-5-PICOLINE;AKOS BBS-00002970;2-Hydroxy-5-methyL;5-METHYL-2-PYRIDINOL;6-HYDROXY-3-PICOLINE;5-METHYL-PYRIDIN-2-OL;2-Hydroxy-5-Piocoline

CBNumber:: CB5114924

Molecular Formula:: C6H7NO

Molecular Weight:: 109.13

MDL Number:: MFCD03092888

MOL File:: 1003-68-5.mol

MSDS File:: SDS

Last updated:2026-01-13 11:20:35

Product description	Number	Pack Size	Price
5-METHYL-2(1H)-PYRIDINONE AldrichCPR	T162647	1MG	$152
2-Hydroxy-5-methylpyridine 97%	593427	1g	$59.1
2-Hydroxy-5-methylpyridine >98.0%(GC)(T)	H1167	5g	$22
2-Hydroxy-5-methylpyridine >98.0%(GC)(T)	H1167	25g	$69
2-Hydroxy-5-methylpyridine	H948300	1g	$55
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2-Hydroxy-5-methylpyridine Properties

Melting point	183-187 °C (lit.)
Boiling point	304.2±15.0 °C(Predicted)
Density	1.053±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka	12.43±0.10(Predicted)
form	Solid
color	Pale Yellow to Light Yellow
BRN	107074
InChI	InChI=1S/C6H7NO/c1-5-2-3-6(8)7-4-5/h2-4H,1H3,(H,7,8)
InChIKey	SOHMZGMHXUQHGE-UHFFFAOYSA-N
SMILES	C1(=O)NC=C(C)C=C1
CAS DataBase Reference	1003-68-5(CAS DataBase Reference)
FDA UNII	C173P2D70Y
NIST Chemistry Reference	2(1H)-pyridinone, 5-methyl-(1003-68-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

22-37/38-41-36/37/39

Safety Statements

26-36-37

WGK Germany

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
1		0

2-Hydroxy-5-methylpyridine price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T162647	5-METHYL-2(1H)-PYRIDINONE AldrichCPR	1003-68-5	1MG	$152	2026-03-19	Buy
Sigma-Aldrich	593427	2-Hydroxy-5-methylpyridine 97%	1003-68-5	1g	$59.1	2026-03-19	Buy
TCI Chemical	H1167	2-Hydroxy-5-methylpyridine >98.0%(GC)(T)	1003-68-5	5g	$22	2026-03-19	Buy
TCI Chemical	H1167	2-Hydroxy-5-methylpyridine >98.0%(GC)(T)	1003-68-5	25g	$69	2026-03-19	Buy
TRC	H948300	2-Hydroxy-5-methylpyridine	1003-68-5	1g	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
T162647	1MG	$152	Buy
593427	1g	$59.1	Buy
H1167	5g	$22	Buy
H1167	25g	$69	Buy
H948300	1g	$55	Buy

2-Hydroxy-5-methylpyridine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides. 2-hydroxy-5-methylpyridine and Iodobenzene were the impurities present in Pirfenidone (PFD) drug substance. PFD is a novel antifibrotic agent approved for mild to moderate Idiopathic pulmonary fibrosis (IPF) as orphan drug[1].

Application

2-Hydroxy-5-methylpyridine is widely aapplied in laboratory chemicals, Food, drug, pesticide or biocidal product use.

Definition

ChEBI: 5-Methyl-2-pyridinol is a member of methylpyridines.

Synthesis

3-cyano-6-hydroxypyridine and sodium lauryl sulfate were added to a mixed solvent of n-butanol and water. Subsequently, the temperature was raised to 50 °C., and sulfuric acid water obtained by dissolving 98% sulfuric acid in water was added dropwise at the temperature. After stirring for about 20 minutes, the mixture was cooled to room temperature, and 5% Pd / C was added. The system was replaced with hydrogen, and hydrogenation was carried out at atmospheric pressure for 6 hours. After the reaction was completed, the catalyst was removed by filtration, and the solution was washed with 10% sodium hydroxide aqueous solution. After partially neutralizing to H = 5 and extraction with n-butanol, a solution of crude 3-methyl-6-hydroxypyridine in butanol was obtained. When this solution was quantified by liquid chromatography, the pass-through rate was 99.2%, and the yield of 2-hydroxy-5-methylpyridine was 83%.

References

[1] Suresh Babu Bodempudi, ;K. S. Reddy, Ravichandra Babur. “Development and Substantiation of a RP-HPLC Method for Monitoring of Impurities in Pirfenidone Drug Substance.” American Analytical Chemistry (English) 6 1 (2015): 1019–1029.

2-Hydroxy-5-methylpyridine synthesis

Synthesis of 2-Hydroxy-5-methylpyridine from 2-Bromo-5-methylpyridine

2-Hydroxy-5-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

5-METHYL-2-PIPERIDINONE 2-MERCAPTO-5-METHYLPYRIDINE 2-methyl-2-(5-methylpyridin-2-yloxy)propanoic acid 5,5'-diMethoxycarbonyl-2,2'-bipyridine 3-Methyl-2(1H)-Pyridinethione

1,5-Dimethyl-2(1H)-pyridone

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2-Hydroxy-5-methylpyridine Suppliers

Global( 475)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Wuhan BJM Pharm Inc	027-52341919 13545198479	sales03@benjaminpharmchem.com	China	584	58
Terma Medicare India Pvt.,Ltd	+86-53530655; +8613916485955	shivshanghai@yahoo.com	India	301	58
Suzhou Nordica Biopharma CO.,LTD	+86-18136148818 +86-18567353071	3537297702@qq.com	China	299	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5238	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21594	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58

Supplier	Advantage
career henan chemical co	58
Wuhan BJM Pharm Inc	58
Terma Medicare India Pvt.,Ltd	58
Suzhou Nordica Biopharma CO.,LTD	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from 2-Hydroxy-5-methylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-27	2-Hydroxy-5-methylpyridine 1003-68-5	US $0.00 / gm	100gm	99%min	100kgs	Shanghai Yongzeng Technology Co.,Ltd
2026-03-27	2-Hydroxy-5-methylpyridine 1003-68-5	US $0.00 / KG	1KG	98.0%	10kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-11-18	2-Hydroxy-5-methylpyridine 1003-68-5	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

2-Hydroxy-5-methylpyridine
1003-68-5
US $0.00 / gm
99%min
Shanghai Yongzeng Technology Co.,Ltd

2-Hydroxy-5-methylpyridine
1003-68-5
US $0.00 / KG
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

2-Hydroxy-5-methylpyridine
1003-68-5
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Hydroxy-5-methylpyridine Spectrum

2-Hydroxy-5-methylpyridine(1003-68-5)MS 2-Hydroxy-5-methylpyridine(1003-68-5)¹HNMR 2-Hydroxy-5-methylpyridine(1003-68-5)¹³CNMR 2-Hydroxy-5-methylpyridine(1003-68-5)IR1 2-Hydroxy-5-methylpyridine(1003-68-5)IR2

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6-HYDROXY-3-PICOLINE 5-METHYL-2(1H)PYPRIDINONE 5-METHYL-2(1H)-PYRIDINONE 5-METHYL-2(1H)PYRIDONE 5-METHYL-2-PYRIDINOL 5-METHYL-PYRIDIN-2-OL 5-METHYLPYRIDINE-2-ONE AKOS BBS-00002970 2-HYDROXY-5-METHYLPYRIDINE 2-HYDROXY-5-PICOLINE 5-methyl-2-pyridone 2-Hydroxy-5-Picoline 2-Hydroxy-5-Methyl Pyridine 2-HYDROXY-5-METHYLPYRIDINE 98% 2-Hydroxy-5-Piocoline 2(1H)-Pyridinone, 5-methyl- 2(1H)-Pyridone, 5-methyl- 2-Methyl-6-hydroxypyridine 5-Methyl-1,2-dihydropyridine-2-one 5-Methylpyridin-2(1H)-one 5-Methylpyridine-2-ol 2-Hydroxy-5-methylpyridine 5-Methyl-2(1H)pypridinone 2-Hydroxy-5-picoline 2-Hydroxy-5-methylpyridine ,98% 1,2-Dihydro-5-methyl-2-oxopyridine 5-Methyl-2-oxopyridine 6-Hydroxy-3-picoline 5-Methyl-2-pyridinol 5-Methyl-2(1H)-pyridinone Hydroxy-5-Methylpyrid 5-methyl-(1H)pyridinone Pirfenidone Impurity 2（Pirfenidone EP Impurity B） 2-Hydroxy-5-methyL Perfenidone Impurity 1 5-Methylpyridin-2(1H)-one 98% 2-Hydroxy-5-methylpyridine> 2-Hydro-5-methylpyridine 2-Hydroxy-5-methylpyridine ISO 9001：2015 REACH Big Discount Purity 99% 2-Hydroxy-5-Methylpyridine CAS 1003-68-5 with Best Quality 5-methyl-1,2-dihydropyridin-2-one 2-HYDROXY-5-METHYLPYRIDINEE Pirfenidone EP Impurity B 5-methylpyridin-2(1H)-one 2-Hydroxy-5-Methyle pyridine 2-Hydroxy-5-methylpyridine, 95% Pirfenidone EP Impurity B (Pirfenidone USP Related Compound B) 1003-68-5 Building Blocks Heterocyclic Building Blocks Pyridines C6 Imidazoles Heterocycle-Pyridine series alcohol Pyridine Pyridines Chemical Amines Amines Aromatics Heterocycles Heterocyclic Building Blocks C6