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ChemicalBook >> CAS DataBase List >>Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Structure
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- structure
CAS No.
170858-33-0
Chemical Name:
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
Synonyms
U 101387;PNU 101387;PF-05191680;PNU-101387G;Sonepiprazole;Sonepiprazole hydrate;Sonepiprazole, 10 mM in DMSO;inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor;4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate;(S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide
CBNumber:
CB51245409
Molecular Formula:
C21H27N3O3S
Molecular Weight:
401.52
MDL Number:
MFCD05662325
MOL File:
170858-33-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
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Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Properties

storage temp. room temp
solubility DMSO: >10mg/mL
form powder
color white to off-white
InChI 1S/C21H27N3O3S/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21/h1-8,21H,9-16H2,(H2,22,25,26)/t21-/m0/s1
InChIKey WNUQCGWXPNGORO-NRFANRHFSA-N
SMILES NS(=O)(=O)c1ccc(cc1)N2CCN(CC[C@@H]3OCCc4ccccc34)CC2
FDA UNII O609V24217
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3
Storage Class 11 - Combustible Solids

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0174 Sonepiprazole hydrate ≥98% (HPLC) 170858-33-0 5mg $117 2024-03-01 Buy
Sigma-Aldrich PZ0174 Sonepiprazole hydrate ≥98% (HPLC) 170858-33-0 25mg $426 2024-03-01 Buy
Cayman Chemical 11983 Sonepiprazole ≥98% 170858-33-0 1mg $49 2026-04-30 Buy
Cayman Chemical 11983 Sonepiprazole ≥98% 170858-33-0 5mg $120 2026-04-30 Buy
Cayman Chemical 11983 Sonepiprazole ≥98% 170858-33-0 10mg $213 2026-04-30 Buy
Product number Packaging Price Buy
PZ0174 5mg $117 Buy
PZ0174 25mg $426 Buy
11983 1mg $49 Buy
11983 5mg $120 Buy
11983 10mg $213 Buy

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Chemical Properties, Uses, Production

Description

Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical antipsychotics but it is not effective for positive or negative symptoms of schizophrenia in patients. In a pharmacological model of stress exposure in rhesus monkeys, sonepiprazole reverses stress-induced cognitive deficits.

Uses

Sonepiprazole is a dopamine D4 antagonist with Ki=10 nM.

storage

Store at +4°C

References

[1] K M MERCHANT. Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 279 3: 1392-1403.
[2] RUTH E. TENBRINK. (S)-()-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist[J]. Journal of Medicinal Chemistry, 1996, 39 13: 2435-2437. DOI: 10.1021/jm960084f
[3] MARK H CORRIGAN . Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial[J]. Biological Psychiatry, 2004, 55 5: Pages 445-451. DOI: 10.1016/j.biopsych.2003.10.004
[4] AMY F T ARNSTEN PH.D  Beth M M, PH.D  Kalpana M Ph D. The Selective Dopamine D4 Receptor Antagonist, PNU-101387G, Prevents Stress-Induced Cognitive Deficits in Monkeys[J]. Neuropsychopharmacology, 2000, 23 4: 405-410. DOI: 10.1016/s0893-133x(00)00133-0

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Suppliers

Global Suppliers ( 63)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
UHN Shanghai Research & Development Co., Ltd. 021-58958002 18930822973 sales@uhnshanghai.com China 997 58
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Beijing HuaMeiHuLiBiological Chemical 58
UHN Shanghai Research & Development Co., Ltd. 58
Shanghai HuanChuan Industry Co.,Ltd. 50
EMMX Biotechnology LLC 60
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

View Latest Price from Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sonepiprazole pictures 2026-08-08 Sonepiprazole
170858-33-0
 $36.00-136.00 99.81% 10g TargetMol Chemicals Inc.
  • Sonepiprazole pictures
  • Sonepiprazole
    170858-33-0
  • $36.00-136.00
  • 99.81%
  • TargetMol Chemicals Inc.

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Spectrum

Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-(170858-33-0)1HNMR

170858-33-0 (Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-) Related Search:

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(S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]benzenesulfonaMide PF-05191680 PNU 101387 Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- U 101387 Sonepiprazole 4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate PNU-101387G Sonepiprazole hydrate Benzenesulfonamide, 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]- inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor Sonepiprazole, 10 mM in DMSO 170858-33-0 70858-33-0 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals Sulfur & Selenium Compounds