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9-Aminocamptothecin

9-Aminocamptothecin Structure
9-Aminocamptothecin structure
CAS No.
91421-43-1
Chemical Name:
9-Aminocamptothecin
Synonyms
NSC-603071;1H-Pyrano(3;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN;Campathecin Impurity;CAMPTOTHECIN, 9-AMINO-;9-Aminocamptothecin >Camptothecin Impurity 14;(20S)-9-AMINOCAMPTOTHECIN;9-Aminocamptothecin, >96%
CBNumber:
CB5125434
Molecular Formula:
C20H17N3O4
Molecular Weight:
363.37
MDL Number:
MFCD00909855
MOL File:
91421-43-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:17:04
Product description Number Pack Size Price
9-Aminocamptothecin >95.0%(HPLC) A2063 10mg $350
9-amino Camptothecin ≥95% 17232 1mg $36
9-amino Camptothecin ≥95% 17232 5mg $153
9-amino Camptothecin ≥95% 17232 10mg $203
9-amino Camptothecin ≥95% 17232 25mg $420
More product size
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9-Aminocamptothecin Properties

Melting point 142.0-145.0 °C
Boiling point 819.6±65.0 °C(Predicted)
Density 1.55±0.1 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form powder to crystal
pka 11.23±0.20(Predicted)
color Light yellow to Yellow to Orange
Merck 14,431
InChI InChI=1S/C20H17N3O4/c1-2-20(26)13-7-16-17-10(6-11-14(21)4-3-5-15(11)22-17)8-23(16)18(24)12(13)9-27-19(20)25/h3-7,26H,2,8-9,21H2,1H3/t20-/m0/s1
InChIKey FUXVKZWTXQUGMW-FQEVSTJZSA-N
SMILES N1C2C(=C(N)C=CC=2)C=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
CAS DataBase Reference 91421-43-1(CAS DataBase Reference)
NCI Dictionary of Cancer Terms aminocamptothecin
FDA UNII 5MB77ICE2Q
NCI Drug Dictionary aminocamptothecin

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
RTECS  UQ0490500
HS Code  29349990
NFPA 704
0
2 0

9-Aminocamptothecin price More Price(92)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A2063 9-Aminocamptothecin >95.0%(HPLC) 91421-43-1 10mg $350 2026-04-30 Buy
Cayman Chemical 17232 9-amino Camptothecin ≥95% 91421-43-1 1mg $36 2026-04-30 Buy
Cayman Chemical 17232 9-amino Camptothecin ≥95% 91421-43-1 5mg $153 2026-04-30 Buy
Cayman Chemical 17232 9-amino Camptothecin ≥95% 91421-43-1 10mg $203 2026-04-30 Buy
Cayman Chemical 17232 9-amino Camptothecin ≥95% 91421-43-1 25mg $420 2026-04-30 Buy
Product number Packaging Price Buy
A2063 10mg $350 Buy
17232 1mg $36 Buy
17232 5mg $153 Buy
17232 10mg $203 Buy
17232 25mg $420 Buy

9-Aminocamptothecin Chemical Properties,Uses,Production

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the fruit of Camptotheca acuminata Decne., a plant of the Davidiaceae family.

Uses

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

in vivo

9-Aminocamptothecin (9-Amino-CPT) inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression. 9-Aminocamptothecin is well tolerated at all doses, with no toxic death or weight loss of more than 10% observed in any group[2]. 9-Aminocamptothecin induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective. The results with this pre-clinical model support the evaluation of 9-Aminocamptothecin as antileukemic agent in a phase I trial in patients with AML[3].

IC 50

Topoisomerase I

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

9-Aminocamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

9-Aminocamptothecin Suppliers

Global( 234)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Wuhan ChemNorm Biotech Co.,Ltd. 		+86-27-8439 4403 18971486879 sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Supplier Advantage
Shanghai Zheyan Biotech Co., Ltd. 		58
Chengdu GLP biotechnology Co Ltd 		58
Shochem(Shanghai) Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SIMAGCHEM CORP 		58
Wuhan ChemNorm Biotech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
ANHUI WITOP BIOTECH CO., LTD 		58

View Lastest Price from 9-Aminocamptothecin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
9-Aminocamptothecin pictures 2026-05-30 9-Aminocamptothecin
91421-43-1
 1kg 99 Hangzhou Lucky Biology Co., Ltd
9-amino-CPT pictures 2026-04-20 9-amino-CPT
91421-43-1
 $35.00-93.00 99.13% 10g TargetMol Chemicals Inc.
9-Aminocamptothecin pictures 2025-04-04 9-Aminocamptothecin
91421-43-1
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
  • 9-amino-CPT pictures
  • 9-amino-CPT
    91421-43-1
  • $35.00-93.00
  • 99.13%
  • TargetMol Chemicals Inc.

9-Aminocamptothecin Spectrum

9-Aminocamptothecin(91421-43-1)1HNMR

91421-43-1(9-Aminocamptothecin)Related Search:

10-Hydroxycamptothecin Betaine (+)-Camptothecin 9-Hydroxycamptothecin Aminoethoxyvinyl glycine hydrochloride
Glycine Rubitecan 9-methoxy-7-ethylcamptothecin 7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% Camptothecin
20R-Camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)- SN-38-D3 7-Ethyl-20(R)-camptothecin 9-amino-20-camptothecin
Hydroxyl camptothecine AMINO ACIDS 9-Aminocamptothecin

1of4

4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione 4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)- CAMPTOTHECIN, 9-AMINO-(RG) (S)-10-AMino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di CAMPTOTHECIN, 9-AMINO- AMinocaMptothecin 9-AMINO-CAMPTOTHECIN 9-Amino-20-(S)-camptothecin 10-amino-4(s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione (20S)-9-AMINOCAMPTOTHECIN 9-Aminocamptothecin, >96% 2-aminobenzoic acid [(2R,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]-3-oxolanyl] ester 9-Aminocamptothecin，9-Amino-20-(S)-camptothecin (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione 9-Amino-20(S)-camptothecine NSC-603071 (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano(3 1H-Pyrano(3 9-Aminocamptothecin, 98%, from the fruit of Camptotheca acuminata Decne. 9-Aminocamptothecin > 9-amino-2(S)-camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (4S)- Camptothecin Impurity 14 Campathecin Impurity 9-amino-CPT (9-Aminocamptothecin) 91421-43-1 C20H17N3O4 Pharmaceutical Raw Materials Alkaloids Natural Anti-cancer Medical Materials and It's Derivatives