1H-Inden-1-one, 2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-, (3R)-
- CAS No.
- 2767124-77-4
- Chemical Name:
- 1H-Inden-1-one, 2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-, (3R)-
- Synonyms
- (R)-STU104;(R)-4,6-Dimethoxy-3-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-, (3R)-
- CBNumber:
- CB512710921
- Molecular Formula:
- C18H18O4
- Molecular Weight:
- 298.33
- MDL Number:
- MOL File:
- 2767124-77-4.mol
1H-Inden-1-one, 2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-, (3R)- Chemical Properties,Uses,Production
Uses
(R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis[1].
in vivo
(R)-STU104 (1, 3 and 10 mg/kg; IG for 7 days) ameliorates the symptoms of DSS-induced experimental colitis in mice, and significantly inhibits inflammatory cytokine protein[1].
Pharmacokinetic Parameters of (R)-STU104 in male C57 mice[1].
| IV (5 mg/kg) | PO (30 mg/kg) | |
| Tmax (h) | 0.083 | |
| AUC0-t (μg/L·h) | 7249 | 9895 |
| AUC0-∞ (μg/L·h) | 8635 | 16991 |
| MRT0-∞ (h) | 7.32 | 12.52 |
| Cmax (ng/mL) | 2920 | 2290 |
| t1/2 (ng/mL) | 9.29 | 8.67 |
| VZ (L/kg) | 7.76 | 3.68 |
| CLZ (ng/mL) | 0.58 | 0.29 |
| F (%) | 33% |
| Animal Model: | C57BL/6 mice (dextran sodium sulfate (DSS)-induced acute ulcerative colitis)[1] |
| Dosage: | 1, 3 and 10 mg/kg |
| Administration: | IG, for 7 days |
| Result: | Ameliorated the symptoms of DSS-induced experimental colitis, and significantly inhibited inflammatory cytokine protein TNF-α, IL-1β, IL-6, and IL-23. |
References
[1] Tang ML, et al. Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production. J Med Chem. 2022 May 12;65(9):6690-6709. DOI:10.1021/acs.jmedchem.1c02198
1H-Inden-1-one, 2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-, (3R)- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Inden-1-one, 2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-, (3R)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4667 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| BioPharmaMatrix,Inc. | 0510-86010668 | sales@biopharmamatrix.com | China | 4717 | 55 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9979 | 58 |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 921 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2562 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
View Lastest Price from 1H-Inden-1-one, 2,3-dihydro-4,6-dimethoxy-3-(4-methoxyphenyl)-, (3R)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-17 | (R)-STU104
2767124-77-4
|
US $74.00-272.00 / mg | 99.42% | 10g | TargetMol Chemicals Inc. |
-
- (R)-STU104
2767124-77-4
- US $74.00-272.00 / mg
- 99.42%
- TargetMol Chemicals Inc.
