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ChemicalBook >> CAS DataBase List >>((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt

((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt

((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt Structure
((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt structure
CAS No.
2512223-60-6
Chemical Name:
((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt
Synonyms
((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt
CBNumber:
CB512840646
Molecular Formula:
C13H14D3N3O4S.Na
Molecular Weight:
337.37
MDL Number:
MOL File:
2512223-60-6.mol
MSDS File:
SDS
Last updated:2026-05-28 01:46:25
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((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt Properties

solubility DMSO: soluble; Methanol: soluble
form A solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26496 Metamizole-d3 (sodium salt) ≥99%deuteratedforms(d1-d3) 2512223-60-6 1mg $401 2026-04-30 Buy
Cayman Chemical 26496 Metamizole-d3 (sodium salt) ≥99% deuterated forms (d1-d3) 2512223-60-6 1 mg $364 2024-03-01 Buy
aablocks AA01EQBG Metamizole-d3 (sodium salt) ≥99%deuteratedforms(d1-d3) 2512223-60-6 1mg $401 2026-05-30 Buy
Product number Packaging Price Buy
26496 1mg $401 Buy
26496 1 mg $364 Buy
AA01EQBG 1mg $401 Buy

((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt Chemical Properties, Uses, Production

Description

Metamizole-d3 is intended for use as an internal standard for the quantification of metamizole by GC- or LC-MS. Metamizole is a nonopioid prodrug that is rapidly hydrolyzed to the analgesic and antipyretic metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA).1 It inhibits COX-1 and COX-2 activity (IC50 = ~150 μg/ml for both in cell-free assays), as well as reduces increases in intracellular calcium levels induced by the TRPA1 agonist AITC in isolated rat and mouse dorsal root ganglia and IMR-90 human fibroblasts (IC50s = 30-91 μM in patch-clamp assays).2,3 Metamizole (6, 12, and 25 μg/ml) inhibits ADP- and epinephrine-induced platelet aggregation in human platelet-rich plasma (hPRP).4 It prevents fever induced by LPS, TNF-α, and IL-6, but not arachidonic acid or prostaglandin E2 (PGE2; ）, in rats when administered at a dose of 120 mg/kg.5 Metamizole (250 and 500 mg/kg) increases the paw withdrawal threshold in the paw pressure test, indicating analgesic activity, in rat models of carrageenan-induced acute pain and postoperative incision pain.6

Uses

Metamizole-d3 sodium is the deuterium labeled Metamizole sodium. Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole sodium is a cyclooxygenase-3 (COX-3) inhibitor[1][2].

References

1. Rogosch, T., Sinning, C., Podlewski, A., et al. Novel bioactive metabolites of dipyrone (metamizol) Bioorg. Med. Chem. 20(1),101-107(2012).
2. Campos, C., de Gregorio, R., García-Nieto, R., et al. Regulation of cyclooxygenase activity by metamizol Eur. J. Pharmacol. 378(3),339-347(1999).
3. Nassini, R., Fusi, C., Materazzi, S., et al. The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives Br. J. Pharmacol. 172(13),3397-3411(2015).
4. Papp, J., Sandor, B., Vamos, Z., et al. Antiplatelet effect of acetylsalicylic acid, metamizole and their combination - in vitro and in vivo comparisons Clin. Hemorheol. Microcirc. 56(1),1-12(2014).
5. De Souza, G.E.P., Cardoso, R.A., Melo, M.C.C., et al. A comparative study of the antipyretic effects of indomethacin and dipyrone in rats Inflamm. Res. 51(1),24-32(2002).
6. Ince, I., Aksoy, M., Ahiskalioglu, A., et al. A comparative investigation of the analgesic effects of metamizole and paracetamol in rats J. Invest. Surg. 28(3),173-180(2015).

((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt Preparation Products And Raw materials

Raw materials

Preparation Products

((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
CHINA ISOTOPE CO., LIMITED 02151600108 13062666369 info@isotopechem.com China 4721 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
SHANGHAI ZZBIO CO., LTD. 18019219489 18901678489 tech@zzbioco.com China 12062 58
Xibiao (Shanghai) Technology Co., Ltd 18512111473 18512111473 2238774038@qq.com China 3149 58
Supplier Advantage
CHINA ISOTOPE CO., LIMITED 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
SHANGHAI ZZBIO CO., LTD. 58
Xibiao (Shanghai) Technology Co., Ltd 58

2512223-60-6 (((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt) Related Search:

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((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl-d3)amino)methanesulfonate,monosodiumsalt 2512223-60-6