Methyl 5-aminopyridine-3-carboxylate
- CAS No.
- 36052-25-2
- Chemical Name:
- Methyl 5-aminopyridine-3-carboxylate
- Synonyms
- METHYL 5-AMINONICOTINATE;5-AMINO-NICOTINIC ACID METHYL ESTER;Methyl 5-amino-3-pyridinecarboxylate;methyl 5-aminopyridine-3-carboxylate;Methyl 5-aminopyridine-3-carboxylate ,98%;3-Pyridinecarboxylicacid,5-amino-,methylester;5-Aminopyridine-3-carboxylic acid methyl ester;5-Aminopyridine-3-carboxylic acid methyl ester ,98%;Methyl 5-aminopyridine-3-carboxylate, CAS 36052-25-2;5-AMINO-NICOTINIC ACID METHYL ESTER ISO 9001：2015 REACH
- CBNumber:
- CB5129386
- Molecular Formula:
- C7H8N2O2
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD04038688
- MOL File:
- 36052-25-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 5-aminopyridine-3-carboxylate 97% | 672629 | 1g | $147 |
| Methyl 5-aminopyridine-3-carboxylate 97% | 672629 | 5g | $583 |
| 5-Aminonicotinic acid methyl ester Asreported | 260935 | 500mg | $333 |
| 5-Aminonicotinic acid methyl ester Asreported | 260935 | 1g | $509 |
| 5-Aminonicotinic acid methyl ester Asreported | 260935 | 2g | $695 |
| More product size | |||
| Melting point | 135-137℃ |
|---|---|
| Boiling point | 319.4±22.0 °C(Predicted) |
| Density | 1.238 |
| storage temp. | 2-8°C |
| pka | 4.13±0.20(Predicted) |
| form | solid |
| Appearance | Light brown to yellow Solid |
| BRN | 128569 |
| InChI | InChI=1S/C7H8N2O2/c1-11-7(10)5-2-6(8)4-9-3-5/h2-4H,8H2,1H3 |
| InChIKey | MBGSRKHDEJNWED-UHFFFAOYSA-N |
| SMILES | C1=NC=C(N)C=C1C(OC)=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-26 |
| Safety Statements | 26-36/37/38 |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Methyl 5-aminopyridine-3-carboxylate price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 672629 | Methyl 5-aminopyridine-3-carboxylate 97% | 36052-25-2 | 1g | $147 | 2026-04-30 | Buy |
| Sigma-Aldrich | 672629 | Methyl 5-aminopyridine-3-carboxylate 97% | 36052-25-2 | 5g | $583 | 2023-06-20 | Buy |
| Usbiological | 260935 | 5-Aminonicotinic acid methyl ester Asreported | 36052-25-2 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 260935 | 5-Aminonicotinic acid methyl ester Asreported | 36052-25-2 | 1g | $509 | 2026-06-03 | Buy |
| Usbiological | 260935 | 5-Aminonicotinic acid methyl ester Asreported | 36052-25-2 | 2g | $695 | 2026-06-03 | Buy |
Methyl 5-aminopyridine-3-carboxylate Chemical Properties,Uses,Production
Uses
It is used in organic synthesis and can be used as a starting material for the synthesis of 5-(hydroxymethyl)pyridine-3-ol.
Chemical Properties
Off-white solid
Application
Methyl 5-aminopyridine-3-carboxylate is mainly used as a pharmaceutical intermediate, pesticide intermediate, organic synthesis building block and scientific research reagent. Due to the reactivity of amino and ester groups, it is widely used in the synthesis of heterocyclic drugs, bioactive molecules and functional materials.
Synthesis
67-56-1
24242-19-1
36052-25-2
SOCl2 (10.4 g, 86.9 mmol) was slowly added dropwise to a stirred methanolic solution (100 mL) of 5-aminonicotinic acid (10.0 g, 72.5 mmol) at 0 °C. After gradually warming the reaction mixture to room temperature, the reaction was continued at reflux for 16 hours. After completion of the reaction, the mixture was cooled and concentrated under vacuum. The residue was diluted with deionized water (200 mL) and subsequently neutralized with aqueous NaHCO3 to pH=7. The aqueous phase mixture was extracted with dichloromethane (DCM, 100 mL x 2). The organic layers were combined, washed with saturated saline (100 mL × 2), dried over anhydrous Na2SO4, filtered, and the filtrate was concentrated to dryness under vacuum to give 9.5 g of methyl 5-aminopyridine-3-carboxylate as a white solid in 86% yield. The product was characterized by 1H NMR (DMSO-d6, 400 MHz): δ=8.24 (1H, d), 8.12 (1H, d), 7.42 (1H, dd), 5.65 (2H, brs), 3.84 (3H, s).
References
[1] Patent: WO2013/126608, 2013, A1. Location in patent: Paragraph 00492-00493
[2] Patent: WO2006/117549, 2006, A1. Location in patent: Page/Page column 97
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6305 - 6310
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[5] Chemistry - A European Journal, 2002, vol. 8, # 5, p. 1218 - 1226
Methyl 5-aminopyridine-3-carboxylate Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9996 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
View Lastest Price from Methyl 5-aminopyridine-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 5-AMINO-NICOTINIC ACID METHYL ESTER
36052-25-2
|
$21.00 | 1KG | 99.0% min | 100 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 5-AMINO-NICOTINIC ACID METHYL ESTER
36052-25-2
|
$1.00 | 1KG | 96% | 500kg | Career Henan Chemical Co |
-
- 5-AMINO-NICOTINIC ACID METHYL ESTER
36052-25-2
- $21.00
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-AMINO-NICOTINIC ACID METHYL ESTER
36052-25-2
- $1.00
- 96%
- Career Henan Chemical Co
36052-25-2(Methyl 5-aminopyridine-3-carboxylate)Related Search:
1of4
