dendrobine
- CAS No.
- 2115-91-5
- Chemical Name:
- dendrobine
- Synonyms
- Dendrobine 1%;(-)-Dendrobine;Dendrobine 20%;12-Oxodendrobane;Dendroban-12-one;Dendrobine 2115-91-5;From Dendrobium nobile;Dendrobine, 10 mM in DMSO;Dendrobine Dendroban-12-one;(3α,6α,7R,8S,9R,10α,11α)-Dendrobane-12-one
- CBNumber:
- CB51331533
- Molecular Formula:
- C16H25NO2
- Molecular Weight:
- 263.38
- MDL Number:
- MFCD17676142
- MOL File:
- 2115-91-5.mol
- MSDS File:
- SDS
| Melting point | 135-136℃ |
|---|---|
| Boiling point | 375℃ |
| Density | 1.101 |
| Flash point | 133℃ |
| storage temp. | 4°C, protect from light |
| solubility | ≥60mg/ml in MeOH |
| form | Powder |
| pka | 9.49±0.60(Predicted) |
| color | White to yellow |
| InChI | InChI=1S/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9-,10+,11+,12-,13-,14-,16+/m1/s1 |
| InChIKey | RYAHJFGVOCZDEI-UFFNCVEVSA-N |
| SMILES | N1(C)[C@@]2([H])[C@]3(C)[C@@]([H])(CC[C@]3([H])C1)[C@@]1([H])C(=O)O[C@]2([H])[C@H]1C(C)C |
| FDA UNII | A9N9FB9DPG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| HS Code | 29399990 | |||||||||
| NFPA 704 |
|
dendrobine price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26067 | Dendrobine | 2115-91-5 | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 26067 | Dendrobine | 2115-91-5 | 50mg | $723 | 2024-03-01 | Buy |
| Cayman Chemical | 26067 | Dendrobine | 2115-91-5 | 10mg | $187 | 2024-03-01 | Buy |
| Cayman Chemical | 26067 | Dendrobine | 2115-91-5 | 25mg | $414 | 2024-03-01 | Buy |
| TRC | D231445 | Dendrobine | 2115-91-5 | 10mg | $150 | 2021-12-16 | Buy |
dendrobine Chemical Properties,Uses,Production
Description
Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.
Uses
Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.
Definition
ChEBI: Dendrobine is a member of indoles.
in vivo
Dendrobine (25 mg/kg, ip for 14 days) exhibits antitumor efficacy in A549 xenograft mouse models[2].
Dendrobine (20 mg/kg, po for 20 days) ameliorates gestational diabetes mellitus (GDM) in mouse models[5].
| Animal Model: | A549 xenograft BALB/c mouse models[2] |
| Dosage: | 25 mg/kg |
| Administration: | ip for 14 days |
| Result: | Inhibited tumor growth. |
| Animal Model: | GDM mouse models[5] |
| Dosage: | 20 mg/kg |
| Administration: | po for 20 days |
| Result: | Improved glucose and insulin tolerance, reduced Th17 cells in the spleen of GDM mice. |
References
[1] CHUN-WANG MENG. Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect[J]. Fitoterapia, 2017, 121: Pages 206-211. DOI: 10.1016/j.fitote.2017.07.017
[2] TIAN-HE SONG . Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo[J]. Phytomedicine, 2019, 53: Pages 18-27. DOI: 10.1016/j.phymed.2018.06.018
dendrobine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
View Lastest Price from dendrobine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-30 | Dendrobine
2115-91-5
|
US $33.00-126.00 / mg | 99.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-09-29 | Dendrobine
2115-91-5
|
US $0.00 / mg | 20mg | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2023-02-24 | Dendrobine
2115-91-5
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Dendrobine
2115-91-5
- US $33.00-126.00 / mg
- 99.70%
- TargetMol Chemicals Inc.
-
- Dendrobine
2115-91-5
- US $0.00 / mg
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Dendrobine
2115-91-5
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
