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Ufiprazole

Ufiprazole structure

CAS No.: 73590-85-9

Chemical Name:: Ufiprazole

Synonyms: e SuL;H 168/22;ufiprazole;Pyrmetazol;PyrMetazole;Omeprazolesulfide;OMEPRAZOLE SULPHIDE;Omeprazole EP Imp C;Omeprazole Impurity C;EsoMeprazol iMpurity C

CBNumber:: CB5146932

Molecular Formula:: C17H19N3O2S

Molecular Weight:: 329.42

MDL Number:: MFCD00869021

MOL File:: 73590-85-9.mol

Last updated:2025-10-13 15:09:02

Product description	Number	Pack Size	Price
Omeprazole Sulfide >98.0%(HPLC)(T)	O0437	200mg	$177
Omeprazole Sulfide >98.0%(HPLC)(T)	O0437	1g	$443
Omeprazole sulfide ≥98%	18885	100mg	$62
Omeprazole sulfide ≥98%	18885	1g	$448
Omeprazole sulfide ≥98%	18885	250mg	$142
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Ufiprazole Properties

Melting point	122.0 to 126.0 °C
Boiling point	539.7±60.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.81±0.10(Predicted)
form	Solid
color	White to Off-White
λmax	307nm(MeOH)(lit.)
InChI	InChI=1S/C17H19N3O2S/c1-10-8-18-15(11(2)16(10)22-4)9-23-17-19-13-6-5-12(21-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChIKey	XURCIPRUUASYLR-UHFFFAOYSA-N
SMILES	C1(SCC2=NC=C(C)C(OC)=C2C)NC2=CC(OC)=CC=C2N=1
CAS DataBase Reference	73590-85-9(CAS DataBase Reference)
FDA UNII	6FFV1V867C
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3
HS Code	29339900

Ufiprazole price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	O0437	Omeprazole Sulfide >98.0%(HPLC)(T)	73590-85-9	200mg	$177	2025-07-31	Buy
TCI Chemical	O0437	Omeprazole Sulfide >98.0%(HPLC)(T)	73590-85-9	1g	$443	2025-07-31	Buy
Cayman Chemical	18885	Omeprazole sulfide ≥98%	73590-85-9	100mg	$62	2024-03-01	Buy
Cayman Chemical	18885	Omeprazole sulfide ≥98%	73590-85-9	1g	$448	2024-03-01	Buy
Cayman Chemical	18885	Omeprazole sulfide ≥98%	73590-85-9	250mg	$142	2024-03-01	Buy

Product number	Packaging	Price	Buy
O0437	200mg	$177	Buy
O0437	1g	$443	Buy
18885	100mg	$62	Buy
18885	1g	$448	Buy
18885	250mg	$142	Buy

Ufiprazole Chemical Properties,Uses,Production

Synthesis

Ufiprazole can be synthesized by the condensation reaction of 2-mercapto-5-methoxybenzimidazole and 2-chloromethyl-4-methoxy-3,5-lutidine.

Description

Omeprazole sulfide is an intermediate used in the production of the gastric proton pump inhibitors, omeprazole and esomeprazole . As a degradation product, it is reported to be a direct-acting inhibitor of cytochrome P450 2C19 in pooled human liver microsomes (IC₅₀ = 9.7 μM).

Uses

Omeprazole Sulfide (Esomeprazol EP Impurity C(Omeprazole EP Impurity C)) is a metabolite of Omeprazole.

Definition

ChEBI: Omeprazole sulfide is a member of benzimidazoles.

Biological Activity

Ufiprazole (Omeprazole sulfide) is an intermediate in the production of gastric proton pump inhibitors omeprazole and esomeprazole.

References

[1] Patent: CN108409714, 2018, A. Location in patent: Paragraph 0049-0054; 0063-0067; 0076-0080; 0089-0093
[2] Patent: CN106632256, 2017, A. Location in patent: Paragraph 0008
[3] Patent: CN107400117, 2017, A. Location in patent: Paragraph 0058-0060
[4] Patent: CN107400118, 2017, A. Location in patent: Paragraph 0046; 0047; 0048
[5] Patent: WO2011/12957, 2011, A1. Location in patent: Page/Page column 16

Ufiprazole synthesis

Synthesis of Ufiprazole from 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE and 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

Ufiprazole Preparation Products And Raw materials

Raw materials

2-MERCAPTO-5-METHOXYBENZIMIDAZOLE 4-Desmethoxy-4-nitro Omeprazole Sulfide 4-Desmethoxy-4-chloro Omeprazole Sulfide 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride TETRABUTYLAMMOMIUM BROMIDE

Ethylenediaminetetraacetic acid disodium salt Water Dichloromethane Sodium hydroxide

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Preparation Products

OMEPRAZOLE Esomeprazole magnesium Omeprazole

Ufiprazole Suppliers

Global( 548)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
Shenzhen Excellent Biomedical Technology Co.,Ltd.	+undefined18318671572	sale@ex-biotech.com	China	1092	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12248	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	663	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55

Supplier	Advantage
Coresyn Pharmatech Co., Ltd.	58
Shenzhen Excellent Biomedical Technology Co.,Ltd.	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Wuhan JiyunZen Tech Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55

View Lastest Price from Ufiprazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-13	Omeprazole sulfide 73590-85-9	US $29.00 / mg		98.77%	10g	TargetMol Chemicals Inc.
2025-10-10	Ufiprazole 73590-85-9	US $5.00-0.50 / KG	1KG	99% hplc	500TONS	Wuhan JiyunZen Tech Co., Ltd.
2025-09-25	Esomeprazole Impurity C 73590-85-9	US $0.00-0.00 / mg	10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD

Omeprazole sulfide
73590-85-9
US $29.00 / mg
98.77%
TargetMol Chemicals Inc.

Ufiprazole
73590-85-9
US $5.00-0.50 / KG
99% hplc
Wuhan JiyunZen Tech Co., Ltd.

Esomeprazole Impurity C
73590-85-9
US $0.00-0.00 / mg
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

73590-85-9(Ufiprazole)Related Search:

3,5-Dimethyl-4-methoxy-2-pyridinemethanol Omeprazole OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Esomeprazole Impurity 3 (S)-4-Desmethoxy-4-chloro Omeprazole

4-Hydroxy Omeprazole Omeprazole EP Impurity F Omeprazole Sulfone N-Oxide EsoMeprazole related substance H431/41 2-Pyridinemethanol, 4-hydroxy-3,5-dimethyl- (9CI)

5-METHOXY-2-[(3,5-DIMETHYL-2-PYRIDINYL)-METHYLSULFINYL]-BENZIMIDAZOLE 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Omeprazole EP Impurity G Ondansetron EP Impurity H ammonium 1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylate

OMEPRAZOLE IMP. C (EP): 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]SULPHANYL]-1H-BENZIMIDAZOLE (UFIPRAZOLE) MM STANDARD omeprazole acid Omeprazole Impurity (2-[[(5-hydroxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-3,5-dimethy-l-4(1H)-pyridone)

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5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL THIO-1H-BENZIMIDAZOLE 5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYLMERCAPTOBENZIMIDAZOLE 5-METHOXY-2-[[(3,5-DIMETHYL-4-METHOXY PYRIDINYL)-METHYL]THIO]-1H-BENZIMIDAZOLE 2-[(4-METHOXYETHOXY-3,5-DIMETHYL-2-PYRIDINYL)-METHYLTHIO]-5-METHOXYBENZIMIDAZOLE 2-{[(3,5-dimethyl-4-methoxy-2-pyridinyl)-methyl]-thio}-5-methoxy-1h-benzimidazole OMEPRAZOLE SULPHIDE H 168/22 ufiprazole 5-METHOXY-2-(4-METHOXYL-3,5-DIMETHYL-PYRIDINE-2-YLMETHYLSULFENYL)- 1H- BENZIMIDA Omeprazolesulfide 5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYLTHIO-1H-BENZIMIDAZOLE(UFIPRAZOLE) 2-{[(3,5-Dimethyl-4-methoxy-2-pyridinyl)-methyl]-thio}-5-methoxy-1H benzimi 5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL THIO-1H-BENZIMIDAZOLE =98% (1R,2S,5R)-menthyl-5(s)-cytosin-1-yl-1,3-oxathiolane-2R-carboxylate(CME) 5-METHOXY-2-{[(3,5-DIMETHYL-4-METHOXY-2-PYRIDINYL)METHYL]THIO}-1H-BENZIMIDAZOLE (OMEPRAZOLE SULFIDE) (1R,2S,5R)-MENTHYL-5(S)-CYTOSINE-1-YL-[1,3]-OXATHIOLANE-2R-CARBOXYLATE ( IR, 2S, 5R)-menthyl C5(s)-cytosin C1-yl-[1,3] Coxathiolane-2R-carboxylate (CME) 5-METHOXY-2-(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL THIO-1H-BENZIMIDAZOLE(INTERMEDIATE OF OMEPRAZOLE) 5 - METHOXY -2 ( 3 5- DIMETHY-4- METHOXY PYRIDINE -2 YL )METHYL)THIO) 1H- BENZIM IDAZOLE Omeprazole EP Imp C 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole 5-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylthio)-1H-benziMidazol EsoMeprazo interMediate B Omeprazole Sulfur ether Esomeprazole Magnesium Trihydrate Imp. C (EP): 5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-sulphanyl]-1H-benzimidazole (Ufiprazole) Omeprazole impurity C (PhEur) Pyrmetazol Omeprazole metabolite Omeprazole sulfide Omeprazole Sulfide (Ufiprazole) 5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulphanyl)-1H-benzimidazole Esomeprazole impurity C Omeprazole Impurity C Esomeprazole EP Impurity C(Omeprazole EP Impurity C) 2-[ [(4-methoxy-3,5-dimethylpyridine-2-yl)methyl]thio]-5-methoxy-1H-benzimidazole Omeprazole Sulfide Esomeprazole EP Impurity C / (Omeprazole Sodium EP Impurity C) 2-[(4-methoxy--3,5-dimethyl-2-pyridinyl-)-methyl-thio]-5-methoxy--benz-imidazole 5-METHOXY-2-[[(3,5-DIMETHYL-4-METHOXY PYRIDINYL)-METHYL]THIO]-1H BENZIMIDAZOLE(OMEPRAZOLE SULPHIDE) e SuL 2-[[(3,5-DiMethyl-4-Methoxy-2-pyridyl)Methyl]thio]-5-MethoxybenziMidazole 6-Methoxy-2-[[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]thio]-1H-benziMidazole PyrMetazole Ufiprazole, OMeprazole Sulphide EsoMeprazole related substance C 5-Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfanyl]-1H-benziMidazole(ufiprazole) 2-[(3,5-Dimethyl-4-methoxy-2-pyridyl)methylthio]-5-methoxy-1H-benzimidazole 2-[[(3,5-Dimethyl-4-methoxy-2-pyridyl)methyl]thio]-5-methoxy-1H-benzimidazole 5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1H-benzimidazole 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL) THIO]-1H-BENZIMIDAZOLE ((OMEPRAZOLE SULPHIDE COMPOUND) 6-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methylthio]-1H-benzimidazole 6-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfanyl]-1H-benzimidazole 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfanyl]-1H-benzimidazole 1H-BenziMidazole, 6-Methoxy-2-[[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]thio]- EsoMeprazol iMpurity C OMeprazole IMpurity-C(EP) 6-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylthio)-1H-benzo[d]iMidazole IMp. C (EP): 5-Methoxy-2-[[(4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl]- sulphanyl]-1H-benziMidazole (Ufiprazole) EsoMeprazole EP IMpurity C EsoMeprazole IMp.C ep.