(3-Methylisoxazol-5-yl)methanol
- CAS No.
- 14716-89-3
- Chemical Name:
- (3-Methylisoxazol-5-yl)methanol
- Synonyms
- (3-METHYLISOXAZOL-5-YL)METHANO;5-Isoxazolemethanol, 3-methyl-;(3-Methyl-5-isoxazolyl)methanol;(3-Methylisoxazol-5-yl)methanol;3-Methyl-5-isoxazoleMethanol, 97%;(3-methyl-1,2-oxazol-5-yl)methanol;5-(Hydroxymethyl)-3-methylisoxazole;5-(Hydroxymethyl)-3-methylisoxazole97%;5-(Hydroxymethyl)-3-methylisoxazole 97%;(3-Methylisoxazol-5-yl)methanol - [M89521]
- CBNumber:
- CB51486774
- Molecular Formula:
- C5H7NO2
- Molecular Weight:
- 113.11
- MDL Number:
- MFCD09859210
- MOL File:
- 14716-89-3.mol
- MSDS File:
- SDS
| Melting point | 130 °C |
|---|---|
| Boiling point | 211.82°C (rough estimate) |
| Density | 1.1521 g/L at 25℃ |
| refractive index | n/D1.4792 |
| Flash point | >110℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 13.43±0.10(Predicted) |
| form | liquid |
| color | Colourless |
| InChI | 1S/C5H7NO2/c1-4-2-5(3-7)8-6-4/h2,7H,3H2,1H3 |
| InChIKey | OFSDWHRZVRCPBR-UHFFFAOYSA-N |
| SMILES | CC1=NOC(CO)=C1 |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
(3-Methylisoxazol-5-yl)methanol price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 746088 | 5-(Hydroxymethyl)-3-methylisoxazole 97% | 14716-89-3 | 500mg | $123 | 2023-01-07 | Buy |
| Biosynth | PAA71689 | 5-(Hydroxymethyl)-3-methylisoxazole | 14716-89-3 | 2.5g | $501.5 | 2026-06-04 | Buy |
| Activate Scientific | AS46901 | (3-Methylisoxazol-5-yl)methanol 98% | 14716-89-3 | 1g | $137 | 2026-06-04 | Buy |
| Apolloscientific | OR15967 | 5-(Hydroxymethyl)-3-methylisoxazole ≥95% | 14716-89-3 | 1g | $137 | 2026-06-04 | Buy |
| Apolloscientific | OR15967 | 5-(Hydroxymethyl)-3-methylisoxazole ≥95% | 14716-89-3 | 5g | $531 | 2026-06-04 | Buy |
(3-Methylisoxazol-5-yl)methanol Chemical Properties, Uses, Production
Uses
(Trimethylisoxazole-5-yl)methanol is an alcohol derivative that can be used as a pharmaceutical synthesis intermediate.
Synthesis
4857-42-5
14716-89-3
To a solution of tetrahydrofuran (20 mL) containing 3-methylisoxazole-5-carboxylic acid (3 g, 23.6 mmol) was added lithium aluminum hydride (LiAlH4, 1.8 g, 47.37 mmol) in batches at 0 °C and under nitrogen protection. The reaction mixture was stirred at room temperature for 2 hours before water (2 mL) was slowly added to quench the reaction. Subsequently, the mixture was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent being a petroleum ether solution of 10%-30% ethyl acetate, resulting in 3-methylisoxazole-5-methanol as a colorless oil (1.5 g, 56% yield). Mass spectrum (ES, m/z) [M+H]+ 114.1; 1H NMR (300 MHz, CDCl3) δ 6.09 (s, 1H), 4.74 (s, 2H), 2.30 (s, 3H), 2.10 (brs, 1H).
References
[1] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[2] Patent: WO2016/97870, 2016, A1
[3] ChemMedChem, 2017, vol. 12, # 1, p. 50 - 65
(3-Methylisoxazol-5-yl)methanol Preparation Products And Raw materials
(3-Methylisoxazol-5-yl)methanol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Movin Pharmaceutical Co., Ltd. | 13681854265 | info@moenpharm.com | China | 488 | 55 |
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| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
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