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5-BROMOINDOLINE

5-BROMOINDOLINE structure

CAS No.: 22190-33-6

Chemical Name:: 5-BROMOINDOLINE

Synonyms: AKOS BC-0891;5-BROMOINDOLINE;5-Bromoindoline >5-Bromoindoline 97%;5-Bromoindoline,97%;5-bromodihydroindole;5-Bromoindoline,98+%;Zopiclone Impurity 34;5-BroMo-2,3-dihydroindole;5-BROMO-2,3-DIHYDRO-1H-INDOLE

CBNumber:: CB5149584

Molecular Formula:: C8H8BrN

Molecular Weight:: 198.06

MDL Number:: MFCD00027410

MOL File:: 22190-33-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:17

Product description	Number	Pack Size	Price
5-Bromoindoline 97%	642371	5g	$96
5-Bromoindoline 97%	642371	1g	$51.6
5-Bromoindoline >98.0%(GC)(T)	B3885	1g	$58
5-Bromoindoline >98.0%(GC)(T)	B3885	5g	$169
5-Bromoindoline	B684610	50g	$990
More product size

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5-BROMOINDOLINE Properties

Melting point	36-40 °C (lit.)
Boiling point	114-115°C 5mm
Density	1.5240 g/cm3
refractive index	1.63
Flash point	>230 °F
storage temp.	-20°C
solubility	DMSO, Methanol
pka	4.35±0.20(Predicted)
form	Solid
color	Off-White
BRN	121590
InChI	InChI=1S/C8H8BrN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-2,5,10H,3-4H2
InChIKey	QEDCHCLHHGGYBT-UHFFFAOYSA-N
SMILES	N1C2=C(C=C(Br)C=C2)CC1
CAS DataBase Reference	22190-33-6(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

PackingGroup

III

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		1

5-BROMOINDOLINE price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	642371	5-Bromoindoline 97%	22190-33-6	5g	$96	2026-03-19	Buy
Sigma-Aldrich	642371	5-Bromoindoline 97%	22190-33-6	1g	$51.6	2023-01-07	Buy
TCI Chemical	B3885	5-Bromoindoline >98.0%(GC)(T)	22190-33-6	1g	$58	2026-03-19	Buy
TCI Chemical	B3885	5-Bromoindoline >98.0%(GC)(T)	22190-33-6	5g	$169	2026-03-19	Buy
TRC	B684610	5-Bromoindoline	22190-33-6	50g	$990	2021-12-16	Buy

Product number	Packaging	Price	Buy
642371	5g	$96	Buy
642371	1g	$51.6	Buy
B3885	1g	$58	Buy
B3885	5g	$169	Buy
B684610	50g	$990	Buy

5-BROMOINDOLINE Chemical Properties,Uses,Production

Chemical Properties

White to brown low melting solid

Uses

5-Bromoindoline is a brominated indoline derivative and a product of biocatalyzed halogenation of nucleobase analogs. 5-Bromoindoline is used in the synthetic preparation of biologically active compou nds such as selective human β3 adrenergic receptor agonists.

Synthesis

22190-38-1

22190-33-6

A) 38 g (0.16 mol) of 1-acetyl-5-bromoindoline, 31 g of concentrated hydrochloric acid and 41 g of ethanol were added to the reaction flask and stirred thoroughly to obtain reaction mixture I; B) reaction mixture I was reacted at 78 °C for 4 h. Complete disappearance of the raw materials was confirmed by chromatographic monitoring; C) the reaction mixture was neutralized using 55 g of sodium hydroxide solution; D) the organic phase J and the aqueous phase K were separated; E) the organic phase J was extracted three times using 445 g of chloroform. K; E) Organic phase J was extracted three times with 445 g of chloroform. The organic layers were combined and the solvent was recovered to give 30.74 g of 5-bromodihydroindole in 98.04% yield and ≥99% purity.

References

[1] Patent: CN106432040, 2017, A. Location in patent: Paragraph 0108-0113; 0135-0140; 0162-0167
[2] European Journal of Medicinal Chemistry, 2006, vol. 41, # 1, p. 88 - 100
[3] Tetrahedron Letters, 2004, vol. 45, # 25, p. 4827 - 4830
[4] Patent: CN106966950, 2017, A. Location in patent: Paragraph 0022
[5] Patent: US2011/98311, 2011, A1

5-BROMOINDOLINE synthesis

Synthesis of 5-BROMOINDOLINE from 1-Acetyl-5-bromoindoline

5-BROMOINDOLINE Preparation Products And Raw materials

Raw materials

Acetic anhydride Cyclohexane Acetyl chloride Sodium Triethylamine

Indoline Sodium bisulfite Tetrahydrofuran Ethyl acetate Hydrochloric acid

Bromine Dichloromethane Acetic acid Methanol Sodium hydroxide

Magnesium sulfate 1H-Indole-1-carboxylic acid, 5-bromo-2,3-dihydro-, methyl ester 1-FORMYLINDOLINE

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Preparation Products

5-BROMOINDOLINE Suppliers

Global( 286)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	923	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Win-Win Chemical CO., Limited	0086-577-64498589	sales@win-winchemical.com	CHINA	998	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
Win-Win Chemical CO., Limited	58
Changzhou Ansciep Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 5-BROMOINDOLINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	5-BROMOINDOLINE 22190-33-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	5-BROMOINDOLINE 22190-33-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-06-02	5-Bromoindoline 5-Bromo-2,3-dihydro-1H-indole in stock Factory 22190-33-6	US $1.00 / KG	1KG	TOP 3 Factory in China	Top 3 production capacity Factory	Chemwill Asia Co.,Ltd.

5-BROMOINDOLINE
22190-33-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-BROMOINDOLINE
22190-33-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-Bromoindoline 5-Bromo-2,3-dihydro-1H-indole in stock Factory
22190-33-6
US $1.00 / KG
TOP 3 Factory in China
Chemwill Asia Co.,Ltd.

22190-33-6(5-BROMOINDOLINE)Related Search:

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Benzyl (3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide 8-PHENYLTHEOPHYLLINE 3-(5-CHLOROPYRID-2-YL)CARBAMOYLPYRAZINE-2-CARBOXYLIC ACID(WXG01564) Substituted pyrazine

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5-BROMOINDOLINE AKOS BC-0891 5-BROMO-2,3-DIHYDRO-1H-INDOLE 5-Bromoindoline,98+% 5-Bromoindoline,97% 5-bromodihydroindole 1H-Indole, 5-broMo-2,3-dihydro- 5-BroMo-2,3-dihydroindole 5-Bromoindoline 5-Bromo-2,3-dihydro-1H-indole in stock Factory 5-Bromoindoline 97% 5-Bromoindoline > Zopiclone Impurity 34 22190-33-6 22190-33-67 C8H8BrN Halogenated Heterocycles Heterocyclic Building Blocks Indolines Building Blocks Heterocycle-Indole series Indoles and derivatives Indoline & Oxindole Halogenated Heterocycles Heterocyclic Building Blocks Indolines IndolinesBuilding Blocks