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adoprazine

adoprazine Structure
adoprazine structure
CAS No.
222551-17-9
Chemical Name:
adoprazine
Synonyms
SLV313;SLV 313;adoprazine;Unii-7snb18Q89d;Adoprazine (SLV313);SLV 313;SLV313;SLV-313;Adoprazine, 10 mM in DMSO;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine;Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-;1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine
CBNumber:
CB51518488
Molecular Formula:
C24H24FN3O2
Molecular Weight:
405.46
MDL Number:
MOL File:
222551-17-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-28 17:32:21
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adoprazine Properties

Boiling point 565.0±50.0 °C(Predicted)
Density 1.256
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form Powder
pka 6.07±0.10(Predicted)
color Light yellow to yellow
FDA UNII 7SNB18Q89D

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

adoprazine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0673 Adoprazine 98.60% 222551-17-9 5mg $184 2026-06-04 Buy
ChemScene CS-0673 Adoprazine 98.60% 222551-17-9 10mg $303 2026-06-04 Buy
ChemScene CS-0673 Adoprazine 98.60% 222551-17-9 25mg $529 2026-06-04 Buy
ChemScene CS-0673 Adoprazine 98.60% 222551-17-9 50mg $845 2026-06-04 Buy
ChemScene CS-0673 Adoprazine 98.60% 222551-17-9 100mg $1137 2026-06-04 Buy
Product number Packaging Price Buy
CS-0673 5mg $184 Buy
CS-0673 10mg $303 Buy
CS-0673 25mg $529 Buy
CS-0673 50mg $845 Buy
CS-0673 100mg $1137 Buy

adoprazine Chemical Properties, Uses, Production

Uses

Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics[1].

Biological Activity

Adoprazine (SLV313) is a full agonist at the 5-HT1A receptor with a pEC50 of 9 at the h5-HT1A receptor. Adoprazine (SLV313) is a complete antagonist of D2 and D3 receptors with a pA2 value of 9.3 in hD2 receptor and 8.9 in hD3 receptor. It (SLV313) has atypical antipsychotic properties.

in vitro

Adoprazine (SLV313) has high affinity at human recombinant D 2 , D 3 , D 4 , 5-HT < sub> 2B , and 5-HT 1A receptors, with pK i s of 8.4, 8.4, 8.0, 7.9 and 9.1 , respectively. Adoprazine (SLV313) acts as a high potency dopamine D 2 receptor antagonist and an efficacious serotonin 5-HT 1A receptor agonist, with E max value (% effect of 10 μM 5-HT) of 73 and pK B value of 8.5 .

in vivo

Adoprazine (SLV313) (0.1-10 mg/kg; po; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner.

Animal Model: Male Wistar rats (275-350 g)
Dosage: 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: po; single
Result : Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels.

target

5-HT 1A Receptor

9 (pEC 50 )

D 2 < /sub> Receptor

9.3 (pA2)

D 3 Receptor

8.9 (pA2)

D 4 Receptor

8.0 (pKi)

5-HT 7 Receptor

7.2 (pKi)

5-HT 1A < /sub> Receptor

9.1 (pKi)

D 2 Receptor

8.4 (pKi)

D 3 Receptor

8.4 (pKi)

IC 50

5-HT1A Receptor: 9 (pEC50); D2 Receptor: 9.3 (pA2); D3 Receptor: 8.9 (pA2); D4 Receptor: 8.0 (pKi); 5-HT7 Receptor: 7.2 (pKi); 5-HT1A Receptor: 9.1 (pKi); D2 Receptor: 8.4 (pKi); D3 Receptor: 8.4 (pKi)

References

[1] Andrew C McCreary, et al. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32(1):78-94. DOI:10.1038/sj.npp.1301098
[2] Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70. DOI:10.1016/j.ejphar.2006.01.027

adoprazine Preparation Products And Raw materials

Raw materials

Preparation Products

adoprazine Suppliers

Global Suppliers ( 57)
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
SPIRO PHARMA eric_feng1954@126.com China 9239 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3853 58
Shanghai YuanYe Biotechnology Co., Ltd. 18916372613 yanzihan@shyuanye.com China 87240 60
Chengdu Huachun Technology Co., Ltd 400-1166-196 15982826727 cdhxsj@163.com China 14571 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 sales@linyuepharm.com China 5760 55
Supplier Advantage
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
AdooQ BioScience, LLC 58
LETOPHARM LIMITED 58
SPIRO PHARMA 55
Guangzhou QiYun Biotechnology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Chengdu Huachun Technology Co., Ltd 60
Amadis Chemical Company Limited 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 55

View Latest Price from adoprazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
adoprazine pictures 2026-07-28 adoprazine
222551-17-9
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
Adoprazine pictures 2026-07-14 Adoprazine
222551-17-9
 $58.00-228.00 99.83% 10g TargetMol Chemicals Inc.
Adoprazine pictures 2026-07-13 Adoprazine
222551-17-9
 $58.00-228.00 99.83% 10g TargetMol Chemicals Inc.
  • adoprazine pictures
  • adoprazine
    222551-17-9
  • $0.00
  • 98%
  • Shaanxi Dideu New Materials Co. Ltd
  • Adoprazine pictures
  • Adoprazine
    222551-17-9
  • $58.00-228.00
  • 99.83%
  • TargetMol Chemicals Inc.
  • Adoprazine pictures
  • Adoprazine
    222551-17-9
  • $58.00-228.00
  • 99.83%
  • TargetMol Chemicals Inc.

adoprazine Spectrum

adoprazine(222551-17-9)1HNMR

222551-17-9 (adoprazine) Related Search:

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adoprazine 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine Unii-7snb18Q89d SLV 313 SLV313 Adoprazine (SLV313) SLV 313;SLV313;SLV-313 Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]- 1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine , Adoprazine Adoprazine, 10 mM in DMSO 1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine 222551-17-9