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L-Homocystine

L-Homocystine structure

CAS No.: 626-72-2

Chemical Name:: L-Homocystine

Synonyms: (2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid);H-HoCys-OH;(H-HCY-OH)2;(H-Hcy-OH)?;H-L-HCystine;(H-HOCYS-OH)2;H-L-HOCYSTINE;(H-Hcys-OH) 2;L-Homocystine;(H-HOMOCYS-OH)2

CBNumber:: CB5155903

Molecular Formula:: C8H16N2O4S2

Molecular Weight:: 268.35

MDL Number:: MFCD00020391

MOL File:: 626-72-2.mol

Last updated:2026-01-13 11:22:07

Product description	Number	Pack Size	Price
L-Homocystine ≥98% (HPLC)	H6010	100mg	$129
L-Homocystine ≥98% (HPLC)	H6010	1g	$583.77
L-Homocystine ≥98% (HPLC)	H6010	500mg	$371
L-Homocystine, 99%	H7000	1g	$330
L-Homocystine	H591360	10g	$145
More product size

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L-Homocystine Properties

Melting point	281-284 °C (dec.)(lit.)
alpha	77 º (c=1% in 1N HCl)
Boiling point	507.6±50.0 °C(Predicted)
Density	1.443±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	H2O : 5 mg/mL (18.63 mM; ultrasonic and adjust pH to 3 with H2O)DMSO : 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 5 with HCl)
form	Powder
pka	1.90±0.10(Predicted)
color	Off-white to light yellow
optical activity	73.7°(C=0.97g/100ml 1N HCL)
BRN	1728583
Major Application	cell analysis peptide synthesis
InChI	InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6-/m0/s1
InChIKey	ZTVZLYBCZNMWCF-WDSKDSINSA-N
SMILES	S(CC[C@H](N)C(O)=O)SCC[C@H](N)C(O)=O
CAS DataBase Reference	626-72-2(CAS DataBase Reference)
FDA UNII	804AS222UE
EPA Substance Registry System	L-Homocystine (626-72-2)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
TSCA	TSCA listed
HS Code	29309090
Storage Class	11 - Combustible Solids

L-Homocystine price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H6010	L-Homocystine ≥98% (HPLC)	626-72-2	100mg	$129	2025-07-31	Buy
Sigma-Aldrich	H6010	L-Homocystine ≥98% (HPLC)	626-72-2	1g	$583.77	2025-07-31	Buy
Sigma-Aldrich	H6010	L-Homocystine ≥98% (HPLC)	626-72-2	500mg	$371	2025-07-31	Buy
Usbiological	H7000	L-Homocystine, 99%	626-72-2	1g	$330	2021-12-16	Buy
TRC	H591360	L-Homocystine	626-72-2	10g	$145	2021-12-16	Buy

Product number	Packaging	Price	Buy
H6010	100mg	$129	Buy
H6010	1g	$583.77	Buy
H6010	500mg	$371	Buy
H7000	1g	$330	Buy
H591360	10g	$145	Buy

L-Homocystine Chemical Properties,Uses,Production

Chemical Properties

L-homocysteine is an aliphatic amino acid with the molecular formula (C8H16N2O4S2). It is a white powder with an acidic taste and is easily soluble in water. It has limited solubility in ethanol. L-homocysteine has a sulfhydryl group on its side chain, which allows it to form disulfide bonds with other L-homocysteine residues in proteins. This feature contributes to the stable three-dimensional structure of proteins. As a result, L-homocysteine finds extensive applications in industries such as pharmaceuticals, food, feed, and cosmetics.

Uses

Increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.

Definition

ChEBI: L,L-homocystine is a homocystine in which both chiral centres have L configuration. It is functionally related to a L-homocysteine. It is a tautomer of a L,L-homocystine zwitterion.

Biological Activity

L-Homocystine is the oxidized member of the L-homocysteine:L-homocystine pair. Homocysteine/homocystine is derived from methionine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

Synthesis

L-homoserine(626-72-2) is biosynthesized from L-aspartate, which is synthesized from oxaloacetate, a TCA cycle intermediate. Homoserine is activated through esterification to form the O-acetyl ester by the enzyme homoserine O-acetyltransferase. In certain organisms, including the yeast Saccharomyces cerevisiae and certain bacteria, hydrogen sulfide reacts with O-acetyl-L-homoserine, replacing the acetyl group and forming L-homocysteine.
L-homocysteine biosynthesis

Purification Methods

The acid (3g) is dissolved in freshly boiled H2O (30mL) under N2, cooled under N2 (all operations should be under N2), absolute EtOH (100mL) is added, the acid is filtered off, and a second crop is obtained by diluting the filtrate to 500mL with absolute EtOH, kept overnight in a refrigerator, filtered, washed with EtOH and dried in a vacuum. The D(R,R)-form has similar properties but is –ve in M HCl and +ve in H2O. [du Vigneaud & Patterson J Biol Chem 109 101 1935, du Vigneaud & Brown Biochemical Preparations 5 93, 95 1975, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2667-2670 1961, Beilstein 4 III 1643, 4 IV 3199, Koegel et al. J Am Chem Soc 77 5708 1955.]

L-Homocystine Preparation Products And Raw materials

Raw materials

L-Homoserine L-aspartic acid, sodium salt (S)-4-ACETOXY-2-AMINO-BUTYRIC ACID homoserine O-acetyltransferase Hydrogen Sulfide

RIBOMINUS(BACTERIA)

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Preparation Products

L-Homocystine Suppliers

Global( 256)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1061@dideu.com	China	3982	58

Supplier	Advantage
Henan Bao Enluo International TradeCo.，LTD	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from L-Homocystine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-09	L-Homocystine 626-72-2	US $0.00 / KG	1KG	98.0%	5000kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-01-04	L-Homocystine 626-72-2	US $60.00 / mg		99.79%	10g	TargetMol Chemicals Inc.
2025-10-13	L-Homocystine 626-72-2	US $2.00-5.00 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

L-Homocystine
626-72-2
US $0.00 / KG
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

L-Homocystine
626-72-2
US $60.00 / mg
99.79%
TargetMol Chemicals Inc.

L-Homocystine
626-72-2
US $2.00-5.00 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

L-Homocystine Spectrum

L-Homocystine(626-72-2)MS L-Homocystine(626-72-2)¹HNMR L-Homocystine(626-72-2)IR1 L-Homocystine(626-72-2)IR2

626-72-2(L-Homocystine)Related Search:

4-Aminobutyric acid D-2-Aminobutyric acid DL-Homocysteine L-Cystine DL-2-AMINOBUTYRIC ACID

L-Cysteine Selenium sulfide DL-3-Aminobutyric acid Indole-3-butyric acid DL-2-Aminobutyric acid

L(+)-2-Aminobutyric acid Cyproterone acetate N-Acetyl-L-cysteine 3-CARBOXYPROPYL DISULFIDE Butyl disulfide

Methyl propyl disulfide r-Amino Butryric Acid ETHYL PROPYL DISULFIDE

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(2S,2'S)-2,2'-Diamino-(4,4'-dithiobisbutyric acid) 3,3'-(Dithiobismethylene)bisalanine 4,4'-Dithiobis[(2S)-2-aminobutanoic acid] 4,4'-Dithiobis[(S)-2-aminobutanoic acid] 4,4'-Dithiobis[(S)-2-aminobutyric acid] (2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid) (2S,2'S)-4,4'-Dithiobis[2-aMinobutanoic Acid] [S-(R*,R*)]-4,4'-Dithiobis[2-aMinobutanoic Acid] L-Homocystine ,99% L-Homocystine,L-4,4′-Dithiobis(2-aminobutanoic acid) L-HOMOCYSTINE, >=98% (HPLC) (H-L-HomoCys-OH)2 L-Homocystine≥ 99% (Assay) H-HoCys-OH L-4,4'-Dithiobis(2-aminobutanoic acid) (H-HCY-OH)2 (H-HOCYS-OH)2 (H-HOMOCYS-OH)2 H-L-HOCYSTINE L-4,4'-DITHIO-BIS(2-AMINOBUTANOIC ACID) 4,4’-dithiobis[2-amino-,[s-(theta,theta)]-butanoicaci (H-Hcy-OH)? L-homocystine cell culture tested [S-(R*,R*)]-4,4'-dithiobis[2-aminobutyric] acid 2-amino-4-(3-amino-3-carboxy-propyl)disulfanyl-butanoic acid H-HoCys-OH (H-Hcys-OH) 2 L-Homocystine H-L-HCystine (2S)-2-amino-4-{[(3S)-3-amino-3-carboxypropyl]disulfanyl}butanoic acid Butanoic acid, 4,4'-dithiobis[2-amino-, (2S,2'S)- L-Homocystine USP/EP/BP L Homocystine,Inhibitor,Endogenous Metabolite,LHomocystine,inhibit,L-Homocystine Vincamine Impurity 1( Vincamine EP Impurity A ) L-Homocystine (2S)-2-Amino-4-[[(3S)-3-amino-4-hydroxy-4-oxo-butyl]disulfanyl]butanoic acid 626-72-2 C8H16N2O4S2 Unnatural Amino Acid Derivatives Specialty Synthesis Peptide Synthesis Homo-Amino Acids Amines Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Amino Acids