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tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate structure

CAS No.: 201162-53-0

Chemical Name:: tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate

Synonyms: 3-Boc-3,8-diazabicyclo[3.2.1]octane;tert-butyl 3;3-Boc-3,8-diaza-bicyclo[3...;8-diazabicyclo[3.2.1]octane-3-carboxylate;3,8-Diazabicyclo[3.2.1]octane,N-BOCprotected;tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylat;tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate;1,1-Dimethylethyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate;3,8-Diazabicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester;3,8-Diazabicyclo[3.2.1]octane-3-carboxylic acid, 1,1-dimethylethyl ester

CBNumber:: CB51562401

Molecular Formula:: C11H20N2O2

Molecular Weight:: 212.29

MDL Number:: MFCD17016700

MOL File:: 201162-53-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:46

Product description	Number	Pack Size	Price
tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-3-carboxylate min. 98.0 %	D6441	1G	$67
tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-3-carboxylate min. 98.0 %	D6441	5G	$201
tert-Butyl3,8-diazabicyclo[3.2.1]octane-3-carboxylate	B789765	1g	$85
3-Boc-3,8-Diazabicyclo[3.2.1]octane ≥98.0%	CS-W004996	1g	$100
3-Boc-3,8-diazabicyclo[3.2.1]octane	W4253	100mg	$104

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tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate Properties

Boiling point	295.4±15.0 °C(Predicted)
Density	1.076
storage temp.	2-8°C(protect from light)
pka	9.80±0.20(Predicted)
form	solid
color	White
InChI	InChI=1S/C11H20N2O2/c1-11(2,3)15-10(14)13-6-8-4-5-9(7-13)12-8/h8-9,12H,4-7H2,1-3H3
InChIKey	PSDAEKDIOQXLLC-UHFFFAOYSA-N
SMILES	C12NC(CC1)CN(C(OC(C)(C)C)=O)C2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P312
HS Code	2933998090

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D6441	tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-3-carboxylate min. 98.0 %	201162-53-0	1G	$67	2025-07-31	Buy
TCI Chemical	D6441	tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-3-carboxylate min. 98.0 %	201162-53-0	5G	$201	2025-07-31	Buy
TRC	B789765	tert-Butyl3,8-diazabicyclo[3.2.1]octane-3-carboxylate	201162-53-0	1g	$85	2021-12-16	Buy
ChemScene	CS-W004996	3-Boc-3,8-Diazabicyclo[3.2.1]octane ≥98.0%	201162-53-0	1g	$100	2021-12-16	Buy
AK Scientific	W4253	3-Boc-3,8-diazabicyclo[3.2.1]octane	201162-53-0	100mg	$104	2021-12-16	Buy

Product number	Packaging	Price	Buy
D6441	1G	$67	Buy
D6441	5G	$201	Buy
B789765	1g	$85	Buy
CS-W004996	1g	$100	Buy
W4253	100mg	$104	Buy

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate Chemical Properties,Uses,Production

Uses

tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-3-carboxylate is used in preparation of substituted pyrrolo[2,3-b]pyridines for suppressing toxic endoplasmic reticulum stress.

Synthesis

tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate

201162-52-9

201162-53-0

The general procedure for the synthesis of tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate from tert-butyl 8-benzyl-3,8-diazabicyclo[3.2.1]octane-3-carboxylate was as follows: the product of Example 23A (0.62 g, 0.12 mmol) was dissolved in ethanol (10 mL) and palladium/carbon (Aldrich, 60 mg, 10 wt%) as a catalyst. The reaction was stirred at room temperature for 18 h under an atmosphere of hydrogen (balloon) at 1 atm. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography with an eluent ratio of 1% ammonia:9% methanol:90% dichloromethane to afford tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate, the target compound (0.44 g, 100% yield). Mass spectral analysis (DC1/NH3) showed m/z 213 (M + H)+.

References

[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 5, p. 674 - 681
[2] Patent: US2005/101602, 2005, A1. Location in patent: Page/Page column 35
[3] Patent: US2005/9841, 2005, A1. Location in patent: Page/Page column 16
[4] Patent: US2005/80095, 2005, A1. Location in patent: Page/Page column 19

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate synthesis

Synthesis of tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate from tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate Preparation Products And Raw materials

Raw materials

tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate Ethanol Hydrogen 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane

Preparation Products

tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate Suppliers

Global( 140)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Affinity（Wuhan）Ltd.	+86-+undefined-0411-39805809 +86-+undefined-15841022315	sales@affinitytech.cn	China	126	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16515	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21618	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
Affinity（Wuhan）Ltd.	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-13	Tert-Butyl 3,8-Diazabicyclo[3.2.1]Octane-3-Carboxylate 201162-53-0	US $3.90-5.90 / KG	1KG	99%	g-kg-tons, free sample is available	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2020-01-09	tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate 201162-53-0	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

Tert-Butyl 3,8-Diazabicyclo[3.2.1]Octane-3-Carboxylate
201162-53-0
US $3.90-5.90 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate
201162-53-0
US $1.00 / KG
99%
Career Henan Chemical Co

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate Spectrum

tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate(201162-53-0)¹HNMR

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8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE 1-BOC-3,5-DIMETHYL-PIPERAZINE tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate

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tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate 3-Boc-3,8-diazabicyclo[3.2.1]octane 3,8-Diazabicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester 3-Boc-3,8-diaza-bicyclo[3... tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylat 3,8-Diazabicyclo[3.2.1]octane-3-carboxylic acid, 1,1-dimethylethyl ester 3,8-Diazabicyclo[3.2.1]octane,N-BOCprotected 8-diazabicyclo[3.2.1]octane-3-carboxylate tert-butyl 3 1,1-Dimethylethyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate 3,8-Diazabicyclo[3.2.1]octane-3-carboxylic acid tert-butyl ester - [D6583] 201162-53-0 CHIRAL CHEMICALS