DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE
- CAS No.
- 53389-01-8
- Chemical Name:
- DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE
- Synonyms
- 4-chloropyidine-2,6-dicarboxylate;4-chloropyridine-2,6-dicarboxylate;4-Chloro-2,6-(diethoxycarbonyl)pyridine;Ethyl 4-chloropyidine-2,6-dicarboxylate;ethyl 4-chloro-2, 6-bipyridinecarboxylate;DIETHYL 4-CHLOROPYRIDINE-2,6-DICARBOXYLATE;DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE;Diethyl 4-Chloropyridine- 2,6-pyridinedicarboxylate;4-Chloro-2,6-pyridinedicarboxylic acid diethyl ester;2,6-Pyridinedicarboxylic acid, 4-chloro-, 2,6-diethyl ester
- CBNumber:
- CB5170702
- Molecular Formula:
- C11H12ClNO4
- Molecular Weight:
- 257.67
- MDL Number:
- MFCD00215521
- MOL File:
- 53389-01-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Diethyl4-Chloropyridine-2,6-dicarboxylate | D444110 | 500mg | $85 |
| Diethyl 4-Chloropyridine-2,6-dicarboxylate | 446806 | 250mg | $319 |
| Diethyl 4-chloro-2,6-pyridinedicarboxylate >95% | 045000 | 1g | $10 |
| Diethyl 4-chloropyridine-2,6-dicarboxylate | 4H23-5-Z5 | 500mg | $127 |
| Diethyl4-chloropyridine-2,6-dicarboxylate | 7590AB | 25g | $409 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P260-P280-P312 | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D444110 | Diethyl4-Chloropyridine-2,6-dicarboxylate | 53389-01-8 | 500mg | $85 | 2021-12-16 | Buy |
| Usbiological | 446806 | Diethyl 4-Chloropyridine-2,6-dicarboxylate | 53389-01-8 | 250mg | $319 | 2021-12-16 | Buy |
| Matrix Scientific | 045000 | Diethyl 4-chloro-2,6-pyridinedicarboxylate >95% | 53389-01-8 | 1g | $10 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H23-5-Z5 | Diethyl 4-chloropyridine-2,6-dicarboxylate | 53389-01-8 | 500mg | $127 | 2021-12-16 | Buy |
| AK Scientific | 7590AB | Diethyl4-chloropyridine-2,6-dicarboxylate | 53389-01-8 | 25g | $409 | 2021-12-16 | Buy |
DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE Chemical Properties,Uses,Production
Uses
Diethyl 4-Chloropyridine-2,6-dicarboxylate is a chemical reagent used in the synthesis of luminescent lanthanide complexes. Also used in the production of metal chelating inhibitors against fructose 1,6-bisphosphate (FBP) aldolase in the treatment of infectious bacteria and fungi.
Synthesis
71022-75-8
64-17-5
53389-01-8
The crude 4-chloropyridine-2,6-dicarbonyl dichloride was dissolved in dichloromethane (100 mL) under cooling conditions in an ice bath, followed by the slow addition of a mixture of pyridine (6 mL) and ethanol (5 mL). The reaction mixture was stirred in an ice bath for 5 minutes, then removed from the ice bath and continued to stir at room temperature for 5 hours. Upon completion of the reaction, the volatile solvent was removed by distillation under reduced pressure. The residue was washed with a mixture of 1 M hydrochloric acid (30 mL) and saturated aqueous sodium chloride solution (50 mL) and subsequently extracted with dichloromethane (200 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography using ethyl acetate-hexane (1:4, subsequently adjusted to 1:3) as eluent to give finally diethyl 4-chloro-2,6-pyridinedicarboxylate (800 mg, 62% yield). The product was characterized by 1H NMR (DMSO-d6): δ 1.36 (t, 6H, J = 7.1 Hz, CH3), 3.33 (s, 3H, CH3), 4.40 (q, 4H, J = 7.1 Hz, CH2), 8.31 (s, 2H, Ar).
References
[1] Patent: US2004/198728, 2004, A1. Location in patent: Page/Page column 8
[2] Canadian Journal of Chemistry, 1991, vol. 69, # 7, p. 1107 - 1116
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 21, p. 4703 - 4707
[4] Chemical Communications, 2014, vol. 50, # 71, p. 10323 - 10326
DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29826 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49969 | 58 |
View Lastest Price from DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE
53389-01-8
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE
53389-01-8
|
US $3.00 / KG | 1KG | 90%-99.9% | 1000kg | Career Henan Chemical Co |
-
- DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE
53389-01-8
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE
53389-01-8
- US $3.00 / KG
- 90%-99.9%
- Career Henan Chemical Co
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