2,3-Difluorophenol
- CAS No.
- 6418-38-8
- Chemical Name:
- 2,3-Difluorophenol
- Synonyms
- Difluorophenol;3-Difluorophenol;2,3-DIFLUOROPHENOL;2,3-Difluorophenole;PHENOL, 2,3-DIFLUORO-;2,3-Difluorophenol>2,3-Difluorophenol 98%;2,3-Difluorophenol,98+%;2,3-Difluorophenol ,99%;2,3- twodifluoro phenol
- CBNumber:
- CB5172968
- Molecular Formula:
- C6H4F2O
- Molecular Weight:
- 130.09
- MDL Number:
- MFCD00010262
- MOL File:
- 6418-38-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2,3-Difluorophenol 98% | 265322 | 5g | $57.9 |
| 2,3-Difluorophenol >98.0%(GC) | D2453 | 5g | $30 |
| 2,3-Difluorophenol >98.0%(GC) | D2453 | 25g | $128 |
| 2,3-Difluorophenol | D473448 | 100mg | $60 |
| 2,3-Difluorophenol 99% | JK193978 | 5g | $75 |
| More product size | |||
| Melting point | 39-42 °C (lit.) |
|---|---|
| Boiling point | 54 °C/25 mmHg (lit.) |
| Density | 1.2483 (estimate) |
| Flash point | 134 °F |
| storage temp. | Inert atmosphere,2-8°C |
| pka | 7.71±0.10(Predicted) |
| form | powder to lump to clear liquid |
| color | White or Colorless to Almost white or Almost colorless |
| BRN | 2082265 |
| InChI | InChI=1S/C6H4F2O/c7-4-2-1-3-5(9)6(4)8/h1-3,9H |
| InChIKey | RPEPGIOVXBBUMJ-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=CC(F)=C1F |
| CAS DataBase Reference | 6418-38-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | F,Xn,Xi,C | |||||||||
| Risk Statements | 11-22-36/37/38-34-20/21/22 | |||||||||
| Safety Statements | 26-45-36/37/39-16 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29081000 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,3-Difluorophenol price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 265322 | 2,3-Difluorophenol 98% | 6418-38-8 | 5g | $57.9 | 2026-03-19 | Buy |
| TCI Chemical | D2453 | 2,3-Difluorophenol >98.0%(GC) | 6418-38-8 | 5g | $30 | 2026-03-19 | Buy |
| TCI Chemical | D2453 | 2,3-Difluorophenol >98.0%(GC) | 6418-38-8 | 25g | $128 | 2026-03-19 | Buy |
| TRC | D473448 | 2,3-Difluorophenol | 6418-38-8 | 100mg | $60 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK193978 | 2,3-Difluorophenol 99% | 6418-38-8 | 5g | $75 | 2021-12-16 | Buy |
2,3-Difluorophenol Chemical Properties,Uses,Production
Chemical Properties
white crystalline low melting mass
Uses
Intermediates of Liquid Crystals
Application
2,3-Difluorophenol was used in the synthesis of material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} (PMDFPS) sensitive to toxic organophosphate.
Synthesis
121219-16-7
6418-38-8
Step 1: In a 500 mL round-bottomed flask, dissolve 2,3-difluorophenylboronic acid (30 g, 189.98 mmol, 1.00 eq.) in dichloromethane (250 mL). Hydrogen peroxide (30 mL) was added slowly and dropwise under stirring conditions. The reaction mixture was stirred continuously at 25°C for 2 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with water and saturated saline, the organic phase was dried over anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 2,3-difluorophenol 23 g (93% yield) as a brown oil.
References
[1] K.P. RAJAPPAN NAIR . Supersonic jet microwave rotational spectrum of 2,3-difluorophenol[J]. Journal of Molecular Structure, 2019, 1195: Pages 479-484. DOI:10.1016/j.molstruc.2019.06.004.
[2] WEI HE . Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coating for DMMP detection[J]. Talanta, 2008, 76 3: Pages 698-702. DOI:10.1016/j.talanta.2008.04.022.
[3] E. MARZI M. S J Gorecka. The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates[J]. Synthesis-Stuttgart, 2004, 441 1: 1609-1618. DOI:10.1055/S-2004-829110.
2,3-Difluorophenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 2,3-Difluorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2,3-Difluorophenol
6418-38-8
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | 2,3-Difluorophenol
6418-38-8
|
US $35.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2021-07-13 | 2,3-Difluorophenol
6418-38-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2,3-Difluorophenol
6418-38-8
- US $1.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2,3-Difluorophenol
6418-38-8
- US $35.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,3-Difluorophenol
6418-38-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
