6-oxopiperidine-3-carboxylic acid
- CAS No.
- 22540-50-7
- Chemical Name:
- 6-oxopiperidine-3-carboxylic acid
- Synonyms
- 6-Oxonipecotic acid;6-ketonipecotic acid;5-Carboxy-2-piperidone;UKRORGSYN-BB BBV-082263;6-Oxopiperidine-3-carboxy...;2-Piperidone-5-carboxylic acid;Piperidin-2-one-5-carboxylic acid;6-oxopiperidine-3-carboxylic acid;6-Oxo-3-piperidinecarboxylic acid;3-PIPERIDINECARBOXYLIC ACID, 6-OXO-
- CBNumber:
- CB51786074
- Molecular Formula:
- C6H9NO3
- Molecular Weight:
- 143.14
- MDL Number:
- MFCD08059985
- MOL File:
- 22540-50-7.mol
- MSDS File:
- SDS
| Melting point | 181 - 184°C |
|---|---|
| Boiling point | 437.0±38.0 °C(Predicted) |
| Density | 1.286 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | 4.21±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
6-oxopiperidine-3-carboxylic acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-O858828-50MG | 6-Oxopiperidine-3-carboxylic Acid | 22540-50-7 | 50mg | $91 | 2026-06-03 | Buy |
| TRC | TRC-O858828-10MG | 6-Oxopiperidine-3-carboxylic Acid | 22540-50-7 | 10mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-O858828-100MG | 6-Oxopiperidine-3-carboxylic Acid | 22540-50-7 | 100mg | $109 | 2026-06-03 | Buy |
| Matrix Scientific | 112423 | 6-Oxopiperidine-3-carboxylic acid | 22540-50-7 | 1.00g | $72 | 2026-05-18 | Buy |
| Matrix Scientific | 112423 | 6-Oxopiperidine-3-carboxylic acid | 22540-50-7 | 5.00g | $124 | 2026-05-18 | Buy |
6-oxopiperidine-3-carboxylic acid Chemical Properties, Uses, Production
Uses
6-Oxopiperidine-3-carboxylic Acid can be used to treat progranulin associated disorders.
Synthesis
1356405-59-8
22540-50-7
The optically active compound of 1-(2,4-dimethoxybenzyl)-6-oxopiperidine-3-carboxylic acid (1.36 g) was added to anisole (758 μL) and trifluoroacetic acid (10 mL) as a starting material, and the reaction mixture was stirred for 6 hours at 80 °C. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently concentrated under reduced pressure. Diisopropyl ether was added to the concentrated residue and the mixture was stirred at room temperature. The insoluble solid was collected by filtration and dried under reduced pressure to afford the target product 6-oxopiperidine-3-carboxylic acid (628 mg). The structure of the product was confirmed by 1H-NMR (DMSO-D6): δ 1.75-1.88 (m, 1H), 1.91-2.01 (m, 1H), 2.11-2.24 (m, 2H), 2.66-2.73 (m, 1H), 3.21-3.32 (m, 2H), 7.45 (s, 1H), 12.51 (br s, 1H).
References
[1] Patent: US2013/85132, 2013, A1. Location in patent: Paragraph 0754; 0771; 0772; 0773
6-oxopiperidine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-oxopiperidine-3-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Shijiazhuang Lickon PharmaTech Co., Ltd. | 031185291771 13832391721 | yaofeng2005@163.com | China | 947 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4563 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3970 | 60 |
| Shanghai Sainty Biotechnology Co., Ltd. | 021-58957915 17721108391 | 907522080@qq.com | China | 997 | 55 |
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