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4-Chloro-6-trifluoromethylpyrimidine

4-Chloro-6-trifluoromethylpyrimidine structure

CAS No.: 37552-81-1

Chemical Name:: 4-Chloro-6-trifluoromethylpyrimidine

Synonyms: IFLAB-BB F2124-0884;4-chloro-6-trifluorMethylpyriMidine;4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE;6-Chloro-4-(trifluoromethyl)pyrimidine;4-Chloro-6-(trifluoromethyl)-1,3-diazine;PYRIMIDINE, 4-CHLORO-6-(TRIFLUOROMETHYL)-;4-Chloro-6-(trifluoromethyl)pyrimidine,95%;4-CHLORO-6-(TRIFLUOROMETHYL)PYRIMIDINE ,98%;4-Chloro-6-trifluoromethylpyrimidine ISO 9001：2015 REACH

CBNumber:: CB5178980

Molecular Formula:: C5H2ClF3N2

Molecular Weight:: 182.53

MDL Number:: MFCD04972771

MOL File:: 37552-81-1.mol

MSDS File:: SDS

Last updated:2026-05-28 02:20:18

Product description	Number	Pack Size	Price
4-Chloro-6-(trifluoromethyl)pyrimidine	072267	10.00g	$42
4-Chloro-6-(trifluoromethyl)pyrimidine	072267	25.00g	$57
4-Chloro-6-(trifluoromethyl)pyrimidine	072267	100.00g	$180
4-chloro-6-(trifluoromethyl)pyrimidine 97.0%	C23365	5g	$29
4-chloro-6-(trifluoromethyl)pyrimidine 97.0%	C23365	10g	$50
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4-Chloro-6-trifluoromethylpyrimidine Properties

Melting point	-53--52 °C
Boiling point	35-36 °C(Press: 22 Torr)
Density	1.429 g/cm3
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-4.62±0.18(Predicted)
form	Liquid
color	Colorless to pale yellow
InChI	InChI=1S/C5H2ClF3N2/c6-4-1-3(5(7,8)9)10-2-11-4/h1-2H
InChIKey	TYSPDLZOMUDHQZ-UHFFFAOYSA-N
SMILES	C1=NC(C(F)(F)F)=CC(Cl)=N1
CAS DataBase Reference	37552-81-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Risk Statements

36/37/38

Safety Statements

26-36/37/39

HS Code

2933599590

NFPA 704

	1
2		0

4-Chloro-6-trifluoromethylpyrimidine price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	072267	4-Chloro-6-(trifluoromethyl)pyrimidine	37552-81-1	10.00g	$42	2026-05-18	Buy
Matrix Scientific	072267	4-Chloro-6-(trifluoromethyl)pyrimidine	37552-81-1	25.00g	$57	2026-05-18	Buy
Matrix Scientific	072267	4-Chloro-6-(trifluoromethyl)pyrimidine	37552-81-1	100.00g	$180	2026-05-18	Buy
Synthonix	C23365	4-chloro-6-(trifluoromethyl)pyrimidine 97.0%	37552-81-1	5g	$29	2026-05-06	Buy
Synthonix	C23365	4-chloro-6-(trifluoromethyl)pyrimidine 97.0%	37552-81-1	10g	$50	2026-05-06	Buy

Product number	Packaging	Price	Buy
072267	10.00g	$42	Buy
072267	25.00g	$57	Buy
072267	100.00g	$180	Buy
C23365	5g	$29	Buy
C23365	10g	$50	Buy

4-Chloro-6-trifluoromethylpyrimidine Chemical Properties,Uses,Production

Synthesis

1546-78-7

37552-81-1

General procedure for the synthesis of 4-chloro-6-trifluoromethylpyrimidine from 6-trifluoromethyl-4-hydroxypyrimidine: 6-(trifluoromethyl)pyrimidin-4-ol (5.0 g, 30.5 mmol), phosphorochloridic acid chloride (3.41 mL, 36.6 mmol), and quinoline (2.16 mL, 18.3 mmol) were dissolved in toluene (50 mL), and the reaction was stirred at 100°C for 5 hours. After completion of the reaction, the reaction mixture was diluted with water and extracted three times with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 10% ethyl acetate/hexane) to afford the target product 4-chloro-6-trifluoromethylpyrimidine (1.20 g, 21.6% yield).1H NMR (400 MHz, CDCl3) δ: 9.21 ppm (1H, s), 7.78 ppm (1H, s).

References

[1] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 39-40
[2] Patent: US2005/209241, 2005, A1. Location in patent: Page/Page column 26
[3] Patent: WO2015/17335, 2015, A1. Location in patent: Page/Page column 66
[4] Patent: US2015/197511, 2015, A1. Location in patent: Paragraph 0393; 0394
[5] Patent: WO2015/160654, 2015, A1. Location in patent: Page/Page column 144-145

4-Chloro-6-trifluoromethylpyrimidine synthesis

Synthesis of 4-Chloro-6-trifluoromethylpyrimidine from 4-Hydroxy-6-(trifluoromethyl)pyrimidine

4-Chloro-6-trifluoromethylpyrimidine Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Hexane Quinoline Ethanol Sodium sulfate

Toluene Sodium Phosphorus oxitrichloride Formamidine hydrochloride Ethyl acetate

Hydrochloric acid Methanol Petroleum ether 4-Hydroxy-6-(trifluoromethyl)pyrimidine

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Preparation Products

4-(1-PIPERAZINYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE 6-Trifluoromethyl-pyrimidine-4-carbonitrile tert-Butyl N-1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-ylcarbamate

4-Chloro-6-trifluoromethylpyrimidine Suppliers

Global( 192)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Shanghai Arbor Chemical Co., Ltd.	58
Changzhou Ansciep Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from 4-Chloro-6-trifluoromethylpyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	4-Chloro-6-trifluoromethylpyrimidine 37552-81-1	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2022-01-05	4-chloro-6-trifluormethyl pyrimidine 37552-81-1		1g	98%min	100kgs/month	Shanghai Rlavie Technology Co ltd
2019-12-20	4-Chloro-6-trifluoromethylpyrimidine 37552-81-1	$1.00	100g	98%	200KG	Career Henan Chemical Co

4-Chloro-6-trifluoromethylpyrimidine
37552-81-1
$1.10
99.00%
Dideu Industries Group Limited

4-chloro-6-trifluormethyl pyrimidine
37552-81-1
98%min
Shanghai Rlavie Technology Co ltd

4-Chloro-6-trifluoromethylpyrimidine
37552-81-1
$1.00
98%
Career Henan Chemical Co

4-Chloro-6-trifluoromethylpyrimidine Spectrum

4-Chloro-6-trifluoromethylpyrimidine(37552-81-1)¹HNMR

37552-81-1(4-Chloro-6-trifluoromethylpyrimidine)Related Search:

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Difluorochloromethane 4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE 2-AMINO-4-CHLORO-6-TRIFLUOROMETHYL-PYRIMIDINE Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate 2,4-dichloro-6-(trifluoromethyl)pyrimidine

ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE 2-Chloro-4-(trifluoromethyl)pyrimidine

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PYRIMIDINE, 4-CHLORO-6-(TRIFLUOROMETHYL)- IFLAB-BB F2124-0884 4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE 6-Chloro-4-(trifluoromethyl)pyrimidine 4-CHLORO-6-(TRIFLUOROMETHYL)PYRIMIDINE ,98% 4-chloro-6-trifluorMethylpyriMidine 4-Chloro-6-(trifluoromethyl)-1,3-diazine 4-Chloro-6-(trifluoromethyl)pyrimidine,95% 4-Chloro-6-trifluoromethylpyrimidine ISO 9001：2015 REACH 37552-81-1 67552-81-1 Pyrimidine Boronic Acid Heterocyclic Compounds Pyrimidines Pyrimidine series Fluorine series alkyl chloride