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Benzyl 4-hydroxy-1-piperidinecarboxylate

Benzyl 4-hydroxy-1-piperidinecarboxylate structure

CAS No.: 95798-23-5

Chemical Name:: Benzyl 4-hydroxy-1-piperidinecarboxylate

Synonyms: BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE;1-Cbz-4-hydroxypiperidine;N-CBZ-4-HYDROXY-1-PIPERIDINE;BUTTPARK 93\50-53;1-Cbz-4-piperidinol;1-CBZ-4-hydroxypethidine;N-CBZ-4-HYDROXYPIPERIDINE;1-Carbobenzoxy-4-piperidinol;1-Carbobenzoxy-4-hydroxypiperidine;1-(Benzyloxycarbonyl)-4-piperidinol

CBNumber:: CB5199534

Molecular Formula:: C13H17NO3

Molecular Weight:: 235.28

MDL Number:: MFCD01863722

MOL File:: 95798-23-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:55:09

Product description	Number	Pack Size	Price
Benzyl 4-hydroxy-1-piperidinecarboxylate 97%	513903	10ml	$174
Benzyl 4-Hydroxy-1-piperidinecarboxylate >98.0%(GC)	B4869	5g	$50
Benzyl 4-Hydroxy-1-piperidinecarboxylate >98.0%(GC)	B4869	25g	$161
Benzyl 4-hydroxy-1-piperidinecarboxylate	FB44151	0.1kg	$250
Benzyl 4-hydroxy-1-piperidinecarboxylate	FB44151	0.25kg	$354
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Benzyl 4-hydroxy-1-piperidinecarboxylate Properties

Boiling point	167 °C/0.2 mmHg (lit.)
Density	1.554 g/mL at 25 °C (lit.)
refractive index	n20/D 1.543(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Oil
pka	14.79±0.20(Predicted)
color	Orange
InChI	InChI=1S/C13H17NO3/c15-12-6-8-14(9-7-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12,15H,6-10H2
InChIKey	JKIUUDJOCYHIGY-UHFFFAOYSA-N
SMILES	N1(C(OCC2=CC=CC=C2)=O)CCC(O)CC1
CAS DataBase Reference	95798-23-5(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
Hazard Note	Irritant
HS Code	2933399990

Benzyl 4-hydroxy-1-piperidinecarboxylate price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	513903	Benzyl 4-hydroxy-1-piperidinecarboxylate 97%	95798-23-5	10ml	$174	2023-06-20	Buy
TCI Chemical	B4869	Benzyl 4-Hydroxy-1-piperidinecarboxylate >98.0%(GC)	95798-23-5	5g	$50	2026-04-30	Buy
TCI Chemical	B4869	Benzyl 4-Hydroxy-1-piperidinecarboxylate >98.0%(GC)	95798-23-5	25g	$161	2026-04-30	Buy
Biosynth	FB44151	Benzyl 4-hydroxy-1-piperidinecarboxylate	95798-23-5	0.1kg	$250	2026-06-04	Buy
Biosynth	FB44151	Benzyl 4-hydroxy-1-piperidinecarboxylate	95798-23-5	0.25kg	$354	2026-06-04	Buy

Product number	Packaging	Price	Buy
513903	10ml	$174	Buy
B4869	5g	$50	Buy
B4869	25g	$161	Buy
FB44151	0.1kg	$250	Buy
FB44151	0.25kg	$354	Buy

Benzyl 4-hydroxy-1-piperidinecarboxylate Chemical Properties,Uses,Production

Uses

Reactant for synthesis of:
Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
Piperidine derivatives
Molecular rods
Oxazolidinone-quinolone hybrids and their antibacterial activity
Cyclic prodrug of RGD peptidomimetic

Reactant for oxidation of alcohols

Synthesis

5382-16-1

501-53-1

Benzyl 4-hydroxy-1-piperidinecarboxylate

95798-23-5

General procedure for the synthesis of N-Benzyloxycarbonyl-4-hydroxypiperidine from 4-hydroxypiperidine and benzyl chloroformate: over 30 min, benzyl chloroformate (8.55 mL; 60 mmol) was slowly added dropwise to a well-stirred 4-hydroxypiperidine (5 g; 49.44 mmol), a 1N aqueous NaOH solution (60 mL; 60 mmol) and dioxane (60 mL) in a in a cooled mixture. After dropwise addition, the reaction mixture was continued to stir for 30 minutes. Upon completion of the reaction, the reaction mixture was treated with water and subsequently concentrated and acidified with hydrochloric acid to pH 2. The acidified aqueous phase was extracted with EtOAc, the organic phases were combined, washed with water and saturated brine in that order, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel was the stationary phase, and the eluents were petroleum ether with 50% dichloromethane (60-80 °C) and 10% acetonitrile containing 2% methanol in chloroform solution). The final product was 12.5 g (99% yield) of N-Cbz-4-hydroxypiperidine as an oil; mass spectrum (chemical ionization): m/z 236 (M++1), 218, 192, 174, 91.

References

[1] Patent: WO2005/35495, 2005, A2. Location in patent: Page/Page column 129
[2] Patent: US7759387, 2010, B2. Location in patent: Page/Page column 113
[3] Bioorganic Chemistry, 2002, vol. 30, # 4, p. 285 - 301
[4] Chemistry - A European Journal, 2007, vol. 13, # 17, p. 4859 - 4872
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 12, p. 3236 - 3240

Benzyl 4-hydroxy-1-piperidinecarboxylate synthesis

Synthesis of Benzyl 4-hydroxy-1-piperidinecarboxylate from 1-Cbz-4-Piperidone

Benzyl 4-hydroxy-1-piperidinecarboxylate Preparation Products And Raw materials

Raw materials

BENZYL 4-(4-(METHOXYCARBONYL)PHENYLAMINO)PIPERIDINE-1-CARBOXYLATE benzyl piperidine-1-carboxylate 4-Hydroxypiperidine hydrochloride 1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid Methyl 4-aminobenzoate

N-(Benzyloxycarbonyloxy)succinimide 1-Cbz-4-Piperidone 4-Hydroxypiperidine Water Benzyl chloroformate

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Preparation Products

1-Cbz-4-Piperidone N-CBZ-4-IODOPIPERIDINE 4-Methoxycarbonylmethoxy-piperidine-1-carboxylic acid benzyl ester BENZYL 4-METHOXYPIPERIDINE-1-CARBOXYLATE

Benzyl 4-hydroxy-1-piperidinecarboxylate Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58
Sichuan Biosynce Pharmatech Co., Ltd.	+8619950309693	diane@biosynce.com	China	4871	58

Supplier	Advantage
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hefei Hirisun Pharmatech Co., Ltd	58
CD Chemical Group Limited	58
Labnetwork lnc.	58
PT CHEM GROUP LIMITED	58
Sichuan Biosynce Pharmatech Co., Ltd.	58

View Lastest Price from Benzyl 4-hydroxy-1-piperidinecarboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	Benzyl 4-hydroxy-1-piperidinecarboxylate 95798-23-5	$1.00	1KG	98%	150KG	Career Henan Chemical Co

Benzyl 4-hydroxy-1-piperidinecarboxylate
95798-23-5
$1.00
98%
Career Henan Chemical Co

Benzyl 4-hydroxy-1-piperidinecarboxylate Spectrum

Benzyl 4-hydroxy-1-piperidinecarboxylate(95798-23-5)¹HNMR Benzyl 4-hydroxy-1-piperidinecarboxylate(95798-23-5)IR

95798-23-5(Benzyl 4-hydroxy-1-piperidinecarboxylate)Related Search:

Benzyl benzoate 4-Nitrobenzyl chloroformate Benzyl acetate Benzyl chloride Benzyl formate

Benzyl chloroformate CHLOROPHOSPHONAZO III Benzyl alcohol Benzoyl peroxide Azido-PEG1-CH2CO2H

4-HYDROXY-3-METHYLBENZOIC ACID Isonipecotamide 4-Pyrimidinecarboxylic acid Isonipecotic acid 4,4-Piperidinediol hydrochloride

Benzyl 4-Hydroxypiperidine trans-3,4-Dihydroxypiperidine-1-carboxylic acid benzyl ester

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4-hydroxy-2-piperidinecarboxylic acid (phenylmethyl) ester BENZYL 4-HYDROXY-1-PIPERIDINECARBOXYLATE BENZYL 4-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE BUTTPARK 93\50-53 N-Benzyloxycarbonyl-4-Hydroxypiperidine 4-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 4-HYDROXYPIPERIDINE, N-CBZ PROTECTED 4-Hydroxypiperidine, N-CBZ protected 97% N-CBZ-4-HYDROXYPIPERIDINE Benzyl 4-hydroxy-1-piperidinecarboxylate 97% 1-CBZ-4-hydroxypethidine 1-(Benzyloxycarbonyl)-4-piperidinol 1-(benzyloxycarbonyl)-4-hydroxypiperidine Benzyl 4-Hydroxy-1-piperidinecarboxylate > 1-Piperidinecarboxylic acid, 4-hydroxy-, phenylmethyl ester 1-Carbobenzoxy-4-hydroxypiperidine 1-Carbobenzoxy-4-piperidinol 1-Cbz-4-piperidinol 4-Hydroxy-1-piperidinecarboxylic Acid Benzyl Ester 1-Cbz-4-hydroxypiperidine BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE N-CBZ-4-HYDROXY-1-PIPERIDINE 95798-23-5 Building Blocks Piperidines Heterocyclic Building Blocks API intermediates Building Blocks Heterocyclic Building Blocks Piperidines pharmacetical