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M-NIFEDIPINE

M-NIFEDIPINE Structure
M-NIFEDIPINE structure
CAS No.
21881-77-6
Chemical Name:
M-NIFEDIPINE
Synonyms
BAY-a-4339;M-NIFEDIPINE;Einecs 244-628-5;Nicardipine USP RC C;Benidipine impurity D;Nicardipine Impurity89;Nitrendipine Impurity 2;Nicardipine Impurity 03;Lercanidipine Impurity F;M-Nifedipine Impurity 11
CBNumber:
CB5200528
Molecular Formula:
C17H18N2O6
Molecular Weight:
346.33
MDL Number:
MFCD00195480
MOL File:
21881-77-6.mol
MSDS File:
SDS
Last updated:2025-08-21 22:16:43
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M-NIFEDIPINE Properties

Melting point 211-213℃
Boiling point 478.1±45.0 °C(Predicted)
Density 1.271±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka 2.71±0.70(Predicted)
color Off-White to Light Yellow
FDA UNII N8WQO7VQ30
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501

M-NIFEDIPINE price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC N457015 m-Nifedipine 21881-77-6 100mg $185 2021-12-16 Buy
TRC N457015 m-Nifedipine 21881-77-6 1g $1455 2021-12-16 Buy
American Custom Chemicals Corporation APN0001945 DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE 95.00% 21881-77-6 1G $1963.5 2021-12-16 Buy
Medical Isotopes, Inc. 52504 m-Nifedipine 21881-77-6 1g $2200 2021-12-16 Buy
American Custom Chemicals Corporation APN0001945 DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE 95.00% 21881-77-6 100MG $750.75 2021-12-16 Buy
Product number Packaging Price Buy
N457015 100mg $185 Buy
N457015 1g $1455 Buy
APN0001945 1G $1963.5 Buy
52504 1g $2200 Buy
APN0001945 100MG $750.75 Buy

M-NIFEDIPINE Chemical Properties,Uses,Production

Uses

m-Nifedipine is an impurity of Nifedipine (N457000). Nicardipine USP Related Compound C.

Synthesis

3-Nitrobenzaldehyde

99-61-6

Methyl acetoacetate

105-45-3

M-NIFEDIPINE

21881-77-6

a) Synthesis of dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate A mixture of 75.5 g (0.50 mol) of 3-nitrobenzaldehyde, 116 g (1.00 mol) of methyl acetoacetate, and 55 mL (1.50 mol) of 28% ammonia solution was heated to reflux for 5 hours in 150 mL of methanol. After completion of the reaction, the precipitate was collected by filtration and the filter cake was purified by washing with hot anhydrous ethanol to give 133.5 g of yellow powdery product. The melting point (determined by Kofler's method) was 208°C. The yield was 77.2%.

References

[1] Synthetic Communications, 2012, vol. 42, # 3, p. 454 - 459
[2] Heteroatom Chemistry, 2006, vol. 17, # 4, p. 267 - 271
[3] Catalysis Communications, 2015, vol. 72, p. 63 - 67
[4] Patent: CN107141249, 2017, A. Location in patent: Paragraph 0134; 0135
[5] Monatshefte fur Chemie, 2006, vol. 137, # 1, p. 77 - 81

M-NIFEDIPINE Preparation Products And Raw materials

Raw materials

3-Nitrobenzaldehyde Methyl 3-aminocrotonate Methyl acetoacetate Ammonia Methanol
Ethanol

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Preparation Products

5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

M-NIFEDIPINE Suppliers

Global( 136)Suppliers
Supplier Tel Email Country ProdList Advantage
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32430 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39030 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11922 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Supplier Advantage
Standardpharm Co. Ltd. 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
ANHUI WITOP BIOTECH CO., LTD 		58
CR Corporation Limited 		58
sgtlifesciences pvt ltd 		58
TargetMol Chemicals Inc. 		58
China National Standard Pharmaceutical Corporation Limited 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58

View Lastest Price from M-NIFEDIPINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
m-Nifedipine pictures 2025-08-21 m-Nifedipine
21881-77-6
 US $44.00 / mg 10g TargetMol Chemicals Inc.
  • m-Nifedipine pictures
  • m-Nifedipine
    21881-77-6
  • US $44.00 / mg
  • TargetMol Chemicals Inc.

M-NIFEDIPINE Spectrum

M-NIFEDIPINE(21881-77-6)1HNMR

21881-77-6(M-NIFEDIPINE)Related Search:

Nitrendipine nifedipine(uspgrade Nitrendipine Propyl Ester 5-(Ethoxycarbonyl)-2-(hydroxyMethyl-6-Methyl-4-(3-nitrophenyl)nicotinic Acid Nifedipine Impurity F
NSC 136464 Dehydronitrendipine 3-benzyloxypyridine Benidipine Impurity 6 Benidipine Impurity 22
benidipine Benidipine Impurity Benidipine Impurity 23 Benidipine Impurity 15 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester
bis(1-benzylpiperidin-3-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Butanoic acid, 3-oxo-, 1-(phenylmethyl)-3-piperidinyl ester 1-Benzyl-3-piperidinol

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DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE dimethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDRPYRIDINE-3,5-DICARBOXYLATE(LERCANIDIPINE INTERMEDIATE) 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophen yl)-, dimethyl ester 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester Dimethyl-2,6-dimethyl-4(3-nitrophenyl)-1,4-dihydrpyridine- 3-5-dicarboxylate DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDRPYRIDINE-3-5-DICARBOXYLATE/LERCANIDIPINEOFINTERMEDIATER-1 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester 1,4-Dihydro-2,6-dimethyl-4β-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester 4-(3-Nitrophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethyl ester 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid dimethyl ester BAY-a-4339 Einecs 244-628-5 1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-DiMethyl Ester DiMethyl 4-(M-nitrophenyl)-2,6-diMethyl-1,4-dihydro-3,5- pyridinedicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester M-NIFEDIPINE Benidipine impurity D Lercanidipine Impurity F Nicardipine Hydrochloride EP impurity C Nicardipine USP RC C Nitrendipine Impurity 2 Nitrendipine EP Impurity B M-Nifedipine Impurity 11 Lercanidipine Dimethyl Ester Impurity (Nitrendipine EP Impurity B) Nicardipine Impurity 3（Nicardipine EP Impurity C） Nicardipine dimethyl ester Dimethyl 2,6-Dimethyl-4-(3-nitrophe 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-dimethyl ester Nicardipin Impurity USP RC-C Nitrendipine EP Impurity B (Nicardipine Related Compound C/ Nicardipine Dimethyl Ester Analog/ m-Nifedipine/ Lercanidipine Dimethyl Ester Impurity) NICARDIPINE DIMETHYL ESTER ANALOG Nicardipine Related Compound C (Nicardipine Dimethyl Ester Analog/ m-Nifedipine/ Nitrendipine EP Impurity B) Lercanidipine Dimethyl Ester Impurity (Nitrendipine EP Impurity B/ Nicardipine Related Compound C/ Nicardipine Dimethyl Ester Analog/ m-Nifedipine) Nicardipine Impurity89 Nicardipine EP Impurity C Nicardipine dimethyl esterQ: What is Nicardipine dimethyl ester Q: What is the CAS Number of Nicardipine dimethyl ester Q: What is the storage condition of Nicardipine dimethyl ester Q: What are the applications of Nicardipine dimethyl ester Benidipine Impurity D(Nitrendipine EP Impurity B) Nicardipine Hydrochloride Impurity C Nicardipine Related Compound C Nitrendipine Impurity 2 (Nitrendipine EP Impurity B) Nicardipine EP Impurity C (Nicardipine USP Related Compound C, Nitrendipine EP Impurity B) Nicardipine EP Impurity C（Nitrendipine EP Impurity B、Benidipine impurity D、Lercanidipine Impurity F） NICARDIPINE DIMETHYL ESTER ALOG Nicardipine EP Impurity 3 Nicardipine Impurity 03 NICARELATED COMPOUND IPINE DIMETHYL ESTER 21881-77-6 (intermediate of benidipine hcl)