HUMAN M-CSF
- CAS No.
- 81627-83-0
- Chemical Name:
- HUMAN M-CSF
- Synonyms
- M-CSF;Lanimostim;Csfm;csf-1;MGI-IM;mCSF-1;mM-CSF;RHM-CSF;MGC31930;M-CSF rat
- CBNumber:
- CB5201242
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00241918
- MOL File:
- Mol file
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| form | lyophilized powder |
| color | white to off-white |
| biological source | rat |
| FDA UNII | 2YY7UF3F0W |
| UNSPSC Code | 12352203 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-26 |
| WGK Germany | 3 |
| RTECS | GI5500000 |
| Storage Class | 11 - Combustible Solids |
HUMAN M-CSF price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | WH0001435M1 | Monoclonal Anti-CSF1 antibody produced in mouse clone 1A9, purified immunoglobulin, buffered aqueous solution | 81627-83-0 | 100μg | $580 | 2026-04-30 | Buy |
| Sigma-Aldrich | SRP3332 | M-CSF rat Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) | 81627-83-0 | 10μg | $462 | 2026-04-30 | Buy |
| Sigma-Aldrich | SRP3247 | M-CSF from rat recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | 81627-83-0 | 10μg | $381 | 2026-04-30 | Buy |
| Sigma-Aldrich | SRP3221 | M-CSF from mouse Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | 81627-83-0 | 10μG | $277 | 2026-04-30 | Buy |
| Sigma-Aldrich | SRP3110 | M-CSF human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | 81627-83-0 | 10μg | $236 | 2026-04-30 | Buy |
HUMAN M-CSF Chemical Properties,Uses,Production
Uses
Antineoplastic; anti-infective growth factor that acts on both progenitor and mature cells of the macrophage line.
Uses
Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
General Description
M-CSF (macrophage colony-stimulating factor) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The protein works through its receptor CSF1R (colony stimulating factor 1 receptor). The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4kDa homodimeric protein containing two 156 amino acid polypeptide subunits.
Biochem/physiol Actions
M-CSF (macrophage colony-stimulating factor) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. M-CSF also works as a pleiotropic growth factor and plays a crucial role in reproduction and organogenesis. Absence of it can result in reduced growth, neurological and reproductive problems, developmental defects in the mammary gland, bone and pancreas. M-CSF is also involved in the pathogenesis of cancer.
Description
Macrophage Colony Stimulating Factor Human Recombinant produced in E.coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 37.1 KD. MCSF is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. MCSF induces cells of the monocyte/macrophage lineage. MCSF plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
HUMAN M-CSF Preparation Products And Raw materials
Raw materials
Preparation Products
HUMAN M-CSF Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Jinglin Biotechnology Co., Ltd. | 17711399154 | 3211919385@qq.com | China | 1815 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Shanghai Kanglang Biotechnology Co., Ltd. | 021-61998208 18217752821; | sales@klbio.cn | China | 9619 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 9925 | 58 |
| Shanghai Yingxin Laboratory Equipment Co., Ltd. | 021-59178156 17002132182 | 3146474380@qq.com | China | 9997 | 58 |
