4,6-Dimethyl-2-methylsulfonylpyrimidine
- CAS No.
- 35144-22-0
- Chemical Name:
- 4,6-Dimethyl-2-methylsulfonylpyrimidine
- Synonyms
- DLMSP;VITAS-BB TBB000242;4,6-Dimethyl-2-methy;Ambrisentan Impurity 6;4,6-Dimethyl-2-(methylsulfonyl;4,6-dimethyl-2-mesyl-pyrimidine;6-DiMethyl-2-MethylsulfonylpyriMidine;4,6-DIMETHY-2-METHYLSULFONYLPYRIMIDINE;4,6-diMethyl-2-Methylsulfonyl pyridine;4,6-DIMETHYL-2-METHYLSULFONYLPYRIMIDINE
- CBNumber:
- CB5202360
- Molecular Formula:
- C7H10N2O2S
- Molecular Weight:
- 186.23
- MDL Number:
- MFCD03788286
- MOL File:
- 35144-22-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine >98.0%(GC) | D3699 | 5g | $40 |
| 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine >98.0%(GC) | D3699 | 25g | $155 |
| 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine | D446930 | 1g | $110 |
| 4,6-DIMETHYL-2-METHYL SULFONYL PYRIMIDINE 95.00% | APN0000236 | 5G | $130.73 |
| 4,6-Dimethyl-2-methylsulfonylpyrimidine | FD12082 | 25g | $150 |
| More product size | |||
| Melting point | 84-86°C |
|---|---|
| Boiling point | 358.3±45.0 °C(Predicted) |
| Density | 1.239 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | -1.84±0.30(Predicted) |
| form | Crystalline Solid |
| color | Red-brown |
| InChIKey | ZHPSNGCLCHWTRG-UHFFFAOYSA-N |
| CAS DataBase Reference | 35144-22-0(CAS DataBase Reference) |
| FDA UNII | 85VAF5UF4F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
4,6-Dimethyl-2-methylsulfonylpyrimidine price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D3699 | 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine >98.0%(GC) | 35144-22-0 | 5g | $40 | 2026-03-19 | Buy |
| TCI Chemical | D3699 | 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine >98.0%(GC) | 35144-22-0 | 25g | $155 | 2026-03-19 | Buy |
| TRC | D446930 | 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine | 35144-22-0 | 1g | $110 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | APN0000236 | 4,6-DIMETHYL-2-METHYL SULFONYL PYRIMIDINE 95.00% | 35144-22-0 | 5G | $130.73 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD12082 | 4,6-Dimethyl-2-methylsulfonylpyrimidine | 35144-22-0 | 25g | $150 | 2021-12-16 | Buy |
4,6-Dimethyl-2-methylsulfonylpyrimidine Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
4,6-Dimethyl-2-(methylsulfonyl)pyrimidine is a reactant used in the preparation of [(dimethylpyrimidinyl)oxy]diphenyl butyric acid derivatives as endothelin receptor antagonists.
Synthesis
14001-64-0
35144-22-0
General procedure for the synthesis of 2-methylsulfonyl-4,6-dimethylpyrimidines from 4,6-dimethyl-2-methylthiopyrimidines: 15.9 g (103 mmol) of 4,6-dimethyl-2-methylthiopyrimidines was dissolved in a solvent mixture of 120 mL of dichloromethane and 110 mL of water. Chlorine gas was passed through at 0 °C until the solution took on a yellow color and saturated. Upon completion of the reaction, the solution was purged with nitrogen to remove excess chlorine gas. The organic phase was separated and the aqueous phase was extracted with dichloromethane. The organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure and the product was crystallized by the addition of ether to give 14 g (73% yield) of 2-methylsulfonyl-4,6-dimethylpyrimidine. The melting point of the product was 79-80 °C. 1H-NMR (270 MHz, CDCl3): δ 7.2 (1H, s), 3.4 (3H, s), 2.6 (6H, s).
References
[1] Patent: US6670367, 2003, B1. Location in patent: Page column 15-16
[2] Chemical and Pharmaceutical Bulletin, 1991, vol. 39, # 9, p. 2288 - 2300
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 11, p. 2776 - 2795
4,6-Dimethyl-2-methylsulfonylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21591 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29820 | 58 |
View Lastest Price from 4,6-Dimethyl-2-methylsulfonylpyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-25 | 4,6-Dimethyl-2-methylsulfonylpyrimidine
35144-22-0
|
US $110.00-100.00 / kilograms | 10kilograms | 99% | 100tons | Hebei Dangtong Import and export Co LTD | |
 |
2025-12-16 | Ambrisentan Impurity 6
35144-22-0
|
US $0.00-0.00 / mg | 10mg | 95%+ | 100000 | Moxin Chemicals | |
 |
2025-06-27 | 4,6-Dimethyl-2-methylsulfonylpyrimidine
35144-22-0
|
US $30.00-10.00 / KG | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4,6-Dimethyl-2-methylsulfonylpyrimidine
35144-22-0
- US $110.00-100.00 / kilograms
- 99%
- Hebei Dangtong Import and export Co LTD
-
- Ambrisentan Impurity 6
35144-22-0
- US $0.00-0.00 / mg
- 95%+
- Moxin Chemicals
-
- 4,6-Dimethyl-2-methylsulfonylpyrimidine
35144-22-0
- US $30.00-10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
35144-22-0(4,6-Dimethyl-2-methylsulfonylpyrimidine)Related Search:
1of4
