7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- CAS No.
- 891782-60-8
- Chemical Name:
- 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- Synonyms
- 7-bromo-3,4-dihydroisoquinolin-1(2H)-one;7-BroMo-3,4-dihydro-1(2H)-isoquinolinone;2h-isoquinolin-7-bromo-3,4-Dihydroisoquinolin-1-one;7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;1(2H)-Isoquinolinone, 7-bromo-3,4-dihydro-;7-broMo-1,2,3,4-tetrahydroisoquinolin-1-one;7-Bromo-3,4-dihydroisoquinolin-1(2H)-one 99%
- CBNumber:
- CB5213395
- Molecular Formula:
- C9H8BrNO
- Molecular Weight:
- 226.07
- MDL Number:
- MFCD08437642
- MOL File:
- 891782-60-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one ≥97%(HPLC) | 20584 | 1G | $20 |
| 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one ≥97%(HPLC) | 20584 | 5G | $65 |
| 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one ≥97%(HPLC) | 20584 | 25G | $310 |
| 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one | 118983 | 250.00mg | $226 |
| 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one | 118983 | 1.00g | $558 |
| More product size | |||
| Boiling point | 438.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.559±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 14.41±0.20(Predicted) |
| form | solid |
| color | White to off white |
| InChI | InChI=1S/C9H8BrNO/c10-7-2-1-6-3-4-11-9(12)8(6)5-7/h1-2,5H,3-4H2,(H,11,12) |
| InChIKey | DRDDOAWCDDBYHZ-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC(Br)=C2)CCN1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-52 |
| HS Code | 2933499090 |
7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Chem-Impex | 20584 | 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one ≥97%(HPLC) | 891782-60-8 | 1G | $20 | 2026-05-19 | Buy |
| Chem-Impex | 20584 | 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one ≥97%(HPLC) | 891782-60-8 | 5G | $65 | 2026-05-19 | Buy |
| Chem-Impex | 20584 | 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one ≥97%(HPLC) | 891782-60-8 | 25G | $310 | 2026-05-19 | Buy |
| Matrix Scientific | 118983 | 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one | 891782-60-8 | 250.00mg | $226 | 2026-05-18 | Buy |
| Matrix Scientific | 118983 | 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one | 891782-60-8 | 1.00g | $558 | 2026-05-18 | Buy |
7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Uses,Production
Appearance
Solid
Uses
7-Bromo-3,4-dihydro-2H-isoquinolin-1-one is a useful research chemical.
Synthesis
14548-39-1
891782-60-8
General procedure for the synthesis of 7-bromo-3,4-dihydro-2H-isoquinolin-1-one from 6-bromoindanone: preparation of intermediate 23-1 (7-bromo-3,4-dihydroisoquinolin-1(2H)-one). Sodium azide (0.431 g, 6.63 mmol) was slowly added to a solution of 6-bromo-2,3-dihydro-1H-inden-1-one (1 g, 4.74 mmol) and methanesulfonic acid (15 mL, 231 mmol) in dichloromethane (30 mL) at 0 °C. The reaction mixture was stirred for 15 h at room temperature and then carefully quenched with 1 M aqueous sodium hydroxide solution (50 mL). The aqueous layer was extracted with dichloromethane (3 x 50 mL) and the combined organic layers were washed sequentially with water (20 mL) and brine (20 mL), dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography using a 90:10 gradient elution of hexane-ethyl acetate to pure ethyl acetate to afford 7-bromo-3,4-dihydroisoquinolin-1(2H)-one as a white solid (650 mg, 61% yield). The product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 8.35 (1H, br.s.), 7.08-7.17 (1H, m), 6.98-7.06 (1H, m), 6.95 (1H, d, J=1.98 Hz), 2.93 (2H, t, J=7.59 Hz), 2.49-2.68 (2H, m). Mass spectral analysis showed m/z 226,228 (M+H)+.
References
[1] Patent: US2010/160303, 2010, A1. Location in patent: Page/Page column 36
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 2452 - 2468
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 9005 - 9017
7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
View Lastest Price from 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
891782-60-8
|
1KG | 98% | 150KG | Career Henan Chemical Co |
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- 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
891782-60-8
- $0.00
- 98%
- Career Henan Chemical Co
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