Ganoderenic acid D
- CAS No.
- 100665-43-8
- Chemical Name:
- Ganoderenic acid D
- Synonyms
- Ganoderenic acid d;Apoptosis,Inhibitor,inhibit,Ganoderenic acid D;(20E)-7β-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-diene-26-oic acid;(20E)-7β-Hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20(22)-dien-26-oic acid;(7beta,20E)-7-Hydroxy-3,11,15,23-tetraoxolanosta-8,20(22)-dien-26-oic acid;Lanosta-8,20(22)-dien-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β,20E)-;(E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
- CBNumber:
- CB52192797
- Molecular Formula:
- C30H40O7
- Molecular Weight:
- 512.6344
- MDL Number:
- MFCD32197329
- MOL File:
- 100665-43-8.mol
- MSDS File:
- SDS
Ganoderenic acid D price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 300301 | Ganoderenic acid D | 100665-43-8 | 10mg | $490 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb259246 | Ganoderenic acid D 98% | 100665-43-8 | 5mg | $654.5 | 2021-12-16 | Buy |
| AvaChem | 3481 | Ganoderenic acid D | 100665-43-8 | 10mg | $590 | 2021-12-16 | Buy |
| AvaChem | 3481 | Ganoderenic acid D | 100665-43-8 | 2mg | $249 | 2021-12-16 | Buy |
| Arctom | CFN90300 | GanoderenicacidD ≥98% | 100665-43-8 | 10mg | $476 | 2021-12-16 | Buy |
Ganoderenic acid D Chemical Properties,Uses,Production
Uses
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. It inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. It also induces HeLa human cervical carcinoma apoptosis.
Definition
ChEBI: Ganoderenic acid D is a triterpenoid.
Biological Activity
Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme (ACE; IC50 = 734 μM). Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively). It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 13.77 μM).
References
[1] TRAN HAI-BANG Kuniyoshi S. Structure–activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme[J]. Phytochemistry Letters, 2015, 12: Pages 243-247. DOI: 10.1016/j.phytol.2015.04.021
[2] WEIMEI RUAN. Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth.[J]. Natural Product Research, 2014, 28 24: 2264-2272. DOI: 10.1080/14786419.2014.938337
[3] YANG JIAO . Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 15: Pages 3556-3561. DOI: 10.1016/j.bmcl.2016.06.023
Ganoderenic acid D Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10242 | 58 |
View Lastest Price from Ganoderenic acid D manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-30 | Ganoderenic acid D
100665-43-8
|
US $172.00-68.00 / mg | 99.05% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Ganoderenic acid D
100665-43-8
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2020-01-18 | Ganoderenic acid D
100665-43-8
|
US $3.00 / KG | 1KG | 98% | 1kg , 5kg, 50kg | Career Henan Chemical Co |
-
- Ganoderenic acid D
100665-43-8
- US $172.00-68.00 / mg
- 99.05%
- TargetMol Chemicals Inc.
-
- Ganoderenic acid D
100665-43-8
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Ganoderenic acid D
100665-43-8
- US $3.00 / KG
- 98%
- Career Henan Chemical Co
