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2-HYDROXY-5-NITROBENZYL BROMIDE

2-HYDROXY-5-NITROBENZYL BROMIDE structure

CAS No.: 772-33-8

Chemical Name:: 2-HYDROXY-5-NITROBENZYL BROMIDE

Synonyms: KOSHLAND I;KOSHLAND REAGENT;KOSHLAND'S REAGENT;KOSHLAND'S REAGENT I;Koshland's reagent 1;α-bromo-4-nitro-o-creso;α-bromo-4-nitro-o-cresol;a-Bromo-4-nitro-o-cresol;2-BROMOMETHYL-4-NITROPHENOL;ALPHA-BROMO-4-NITRO-O-CRESOL

CBNumber:: CB5229370

Molecular Formula:: C7H6BrNO3

Molecular Weight:: 232.03

MDL Number:: MFCD00007340

MOL File:: 772-33-8.mol

MSDS File:: SDS

Last updated:2025-07-04 15:13:40

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2-HYDROXY-5-NITROBENZYL BROMIDE Properties

Melting point	144-149 °C(lit.)
Boiling point	383.0±32.0 °C(Predicted)
Density	1.795
refractive index	1.6090 (estimate)
storage temp.	2-8°C
solubility	chloroform: soluble25mg/mL, clear, yellow
pka	6.16±0.30(Predicted)
form	Crystalline Powder
color	Beige to light brown
BRN	1868798
InChI	InChI=1S/C7H6BrNO3/c8-4-5-3-6(9(11)12)1-2-7(5)10/h1-3,10H,4H2
InChIKey	KFDPCYZHENQOBV-UHFFFAOYSA-N
SMILES	C1(O)=CC=C([N+]([O-])=O)C=C1CBr
CAS DataBase Reference	772-33-8(CAS DataBase Reference)
FDA UNII	DS4XZE4Z7T
EPA Substance Registry System	Phenol, 2-(bromomethyl)-4-nitro- (772-33-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

Hazard Codes

Risk Statements

Safety Statements

26-36/37/39-45

RIDADR

UN 3261 8/PG 2

WGK Germany

TSCA

Yes

HazardClass

PackingGroup

III

HS Code

29089990

NFPA 704

	0
3		0

2-HYDROXY-5-NITROBENZYL BROMIDE price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	162906	2-Hydroxy-5-nitrobenzyl bromide 90%	772-33-8	5g	$67.45	2025-07-31	Buy
TCI Chemical	H0601	2-Hydroxy-5-nitrobenzyl Bromide >95.0%(T)	772-33-8	5g	$146	2025-07-31	Buy
TRC	H950893	2-Hydroxy-5-nitrobenzyl Bromide	772-33-8	5g	$45	2021-12-16	Buy
Frontier Specialty Chemicals	JK247575	2-Hydroxy-5-nitrobenzyl Bromide 95%	772-33-8	5g	$38	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0011683	2-HYDROXY-5-NITRO BENZYL BROMIDE 95.00%	772-33-8	5G	$830.74	2021-12-16	Buy

Product number	Packaging	Price	Buy
162906	5g	$67.45	Buy
H0601	5g	$146	Buy
H950893	5g	$45	Buy
JK247575	5g	$38	Buy
HCH0011683	5G	$830.74	Buy

2-HYDROXY-5-NITROBENZYL BROMIDE Chemical Properties,Uses,Production

Chemical Properties

Beige to yellow crystalline powder

Uses

Reagent for sulfhydryl modification.1

Uses

2-Hydroxy-5-nitrobenzyl bromide is a chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules..

Uses

2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 1448, 1964 DOI: 10.1021/ja01061a045

General Description

2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent.

Purification Methods

Crystallise the bromide from *benzene or *benzene/ligroin. It is slightly soluble in EtOH, soluble in *C6H6 and AcOH, and very soluble in ligroin. [Beilstein 6 H 367.]

2-HYDROXY-5-NITROBENZYL BROMIDE synthesis

Synthesis of 2-HYDROXY-5-NITROBENZYL BROMIDE from 2-BROMO-5-NITROTOLUENE

2-HYDROXY-5-NITROBENZYL BROMIDE Preparation Products And Raw materials

Raw materials

Hydrogen bromide Benzene 4-Nitrophenol Phosphorus tribromide Dimethoxymethane

Sulfuric acid 4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE 2-CHLOROMETHYL-4-NITROPHENOL 2-BROMO-5-NITROTOLUENE

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Preparation Products

2-(HYDROXYMETHYL)-4-NITROBENZENOL (2-Butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone Pinacol

2-HYDROXY-5-NITROBENZYL BROMIDE Suppliers

Global( 111)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Aromsyn Co., Ltd.	+86-0571-85585865 +8613336024896	CB@aromsyn.com	China	19183	58
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19632	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Aromsyn Co., Ltd.	58
Aceschem Inc.	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

2-HYDROXY-5-NITROBENZYL BROMIDE Spectrum

2-HYDROXY-5-NITROBENZYL BROMIDE(772-33-8)MS 2-HYDROXY-5-NITROBENZYL BROMIDE(772-33-8)¹HNMR 2-HYDROXY-5-NITROBENZYL BROMIDE(772-33-8)IR1 2-HYDROXY-5-NITROBENZYL BROMIDE(772-33-8)IR2 2-HYDROXY-5-NITROBENZYL BROMIDE(772-33-8)Raman

772-33-8(2-HYDROXY-5-NITROBENZYL BROMIDE)Related Search:

Cresol Cresol o-Cresol 2-METHOXY-5-NITROBENZYL BROMIDE 2-Methyl-4-nitrophenol

3-Nitrobenzyl bromide 2-(BROMOMETHYL)PHENOL 4-AMINO-2-METHYLPHENOL 2-HYDROXY-5-NITROBENZYL BROMIDE Benzyl bromide

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KOSHLAND I KOSHLAND REAGENT KOSHLAND'S REAGENT KOSHLAND'S REAGENT I ALPHA-BROMO-4-NITRO-2-CRESOL ALPHA-BROMO-4-NITRO-O-CRESOL 2-BROMOMETHYL-4-NITROPHENOL 2-HYDROXY-5-NITROBENZYL BROMIDE 2-(bromomethyl)-4-nitro-pheno o-Cresol, alpha-bromo-4-nitro- Phenol, 2-(bromomethyl)-4-nitro- α-bromo-4-nitro-o-cresol α-Bromo-4-nitro-o-cresol, 2-Bromomethyl-4-nitrophenol, Koshland I, Koshlands Reagent I a-Bromo-4-nitro-o-cresol a-Bromo-4-nitro-o-methylphenol BETA-1-BROMO-4-NITRO-O-CRESOL 2-Hydroxy-5-nitrobenzyl bromide ,95% 2-Hydroxy-5-nitrobenzyl bromide,α-Bromo-4-nitro-o-cresol, 2-Bromomethyl-4-nitrophenol, Koshland I, Koshland’s Reagent I alpha-Bromo-4-nitro-o-cresol Koshland's Reagent 2-Hydroxy-5-nitrobenzyl bromide 90% Koshland's reagent 1 alpha-Bromo-4-nitro-o-cresol,95% alpha-Bromo-4-nitro-o-cresol,98% 2-Hydroxy-5-nitrobenzylBromide> α-bromo-4-nitro-o-creso 772-33-8 73-1 HOC6H3NO2CH2Br Building Blocks BioChemical Organic Building Blocks Proteomics and Protein Expression Protein Modification Proteomics Reagents for tryptophan modification Oxygen Compounds Phenols Specific Amino Acid Modification Building Blocks C6 to C8 Chemical Synthesis Organic Building Blocks Oxygen Compounds Phenols