Pyrazolo[1,5-a]pyridine-2-carboxylic acid
![Pyrazolo[1,5-a]pyridine-2-carboxylic acid Structure](CAS/GIF/63237-88-7.gif)
- CAS No.
- 63237-88-7
- Chemical Name:
- Pyrazolo[1,5-a]pyridine-2-carboxylic acid
- Synonyms
- pyrazolo[1,5-a]pyridine-2-carb;2-Carboxypyrazolo[1,5-a]pyridine;2-pyrazolo[1,5-a]pyridinecarboxylic acid;Pyraxolo[1,5-a]pyridine-2-carboxylicacid;PYRAZOLO[1,5-A]PYRIDINE-2-CARBOXYLIC ACID;H-pyrazolo[1,5-a]pyridine-2-carboxylic acid;Pyrazolo[1,5-a]pyridine-2-carboxylic acid 97%+;Pyrazolo[1,5-a]pyridine-2-carboxylic acid, tech;5-HYDROXYINDOLINE-2-CARBOXYLIC ACID ETHYL ESTER;Pyrazolo[1,5-α]Pyridine-2-Carboxylic Acid≥ 99% (HPLC)
- CBNumber:
- CB5230385
- Molecular Formula:
- C8H6N2O2
- Molecular Weight:
- 162.15
- MDL Number:
- MFCD06739057
- MOL File:
- 63237-88-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 189 °C |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -3.82±0.41(Predicted) |
| form | solid |
| color | Off White |
| InChI | InChI=1S/C8H6N2O2/c11-8(12)7-5-6-3-1-2-4-10(6)9-7/h1-5H,(H,11,12) |
| InChIKey | AYGNAOBAPQNTIL-UHFFFAOYSA-N |
| SMILES | C12=CC(C(O)=O)=NN1C=CC=C2 |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
Pyrazolo[1,5-a]pyridine-2-carboxylic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 288307 | Pyrazolo[1,5-alpha]Pyridine-2-Carboxylic Acid Asreported | 63237-88-7 | 500mg | $347 | 2026-06-03 | Buy |
| Usbiological | 288307 | Pyrazolo[1,5-alpha]Pyridine-2-Carboxylic Acid Asreported | 63237-88-7 | 1g | $549 | 2026-06-03 | Buy |
| Usbiological | 288307 | Pyrazolo[1,5-alpha]Pyridine-2-Carboxylic Acid Asreported | 63237-88-7 | 2g | $758 | 2026-06-03 | Buy |
| Usbiological | 288307 | Pyrazolo[1,5-alpha]Pyridine-2-Carboxylic Acid Asreported | 63237-88-7 | 5g | $1050 | 2026-06-03 | Buy |
| Apolloscientific | OR1408 | Pyrazolo[1,5-a]pyridine-2-carboxylic acid 95% | 63237-88-7 | 250mg | $100 | 2026-06-04 | Buy |
Pyrazolo[1,5-a]pyridine-2-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White to yellow solid
Synthesis
![DIMETHYL PYRAZOLO[1,5-A]PYRIDINE-2,3-DICARBOXYLATE](/CAS/GIF/5825-71-8.gif)
5825-71-8
![Pyrazolo[1,5-a]pyridine-2-carboxylic acid](/CAS/GIF/63237-88-7.gif)
63237-88-7
The general procedure for the synthesis of pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid from dimethyl pyrazolo[1,5-a]pyridine-2,3-dicarboxylate was as follows: dimethyl pyrazolo[1,5-a]pyridine-2,3-dicarboxylate (3.35 g, 14 mmol) was dissolved in 50% sulfuric acid (110 mL) and the reaction was stirred for 2.5 h at 80 °C. The reaction was completed by cooling to 0 °C and adjusting the pH to 9 with 8 M aqueous sodium hydroxide. Upon completion of the reaction, the reaction solution was cooled to 0 °C and the pH was adjusted to 9 with 8 M aqueous sodium hydroxide, followed by adjusting the pH to 3 with 6 M hydrochloric acid. the resulting suspension was separated by filtration, the crystals were washed with water, and dried under reduced pressure to afford pyrazolo[1,5-a]pyridine-2-carboxylic acid (light brown crystals, 1.88 g, 81% yield). The resulting pyrazolo[1,5-a]pyridine-2-carboxylic acid (941 mg, 5.8 mmol) was dissolved in THF (30 mL) under nitrogen protection and stirred at room temperature. Subsequently, THF solution of borane-THF complex (20 mL, 18 mmol, 0.9 M) was added and the reaction was stirred at 70 °C for 3.5 hours. After the reaction solution was cooled to 0 °C, water was added, stirred for a few moments, then 6 N hydrochloric acid was added and heated to reflux for 1 hour. The solvent was removed by distillation under reduced pressure, methanol was added and the solvent was removed by distillation again. The residue was diluted with ethyl acetate and the organic layer was washed sequentially with 1 N aqueous sodium hydroxide, water and saturated saline, dried with anhydrous sodium sulfate, and the solvent was removed by filtration of the insoluble material followed by distillation under reduced pressure to give pyrazolo[1,5-a]pyridin-2-ylmethanol. Pyrazolo[1,5-a]pyridin-2-ylmethanol was converted to pyrazolo[1,5-a]pyridine-2-carbaldehyde by the method of Reference Examples 13-3. Referring to the method of Reference Examples 1-2, the reaction of pyrazolo[1,5-a]pyridine-2-carbaldehyde and (R)-2-methylpropane-2-sulfinamide is utilized to obtain (R)-2-methyl-N-(pyrazolo[1,5-a]pyridin-2-ylmethylene)propane-2-sulfinamide. Finally, (R)-2-methyl-N-(pyrazolo[1,5-a]pyridin-2-ylmethylene)propane-2-sulfinamide was converted to pyrazolo[1,5-a]pyridine-2-carboxylic acid (yellowish oil, 498 mg, 65% yield) with reference to the methods of Reference Examples 1-3.
References
[1] Patent: EP3404021, 2018, A1. Location in patent: Paragraph 0224
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 17, p. 2691 - 2694
[3] Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1149 - 1152
[4] Patent: WO2015/66371, 2015, A1
[5] Patent: CN107778310, 2018, A. Location in patent: Paragraph 0044; 0045
Pyrazolo[1,5-a]pyridine-2-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai ZiHao Pharmaceutical Co., Ltd. | 021-13482410-12 13482410112; | 362383684@qq.com | China | 750 | 58 |
| Shanghai Huiyu Biological Technology Co., LTD | 17280940401 | huiyu_bio@126.com | China | 1079 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 |
View Latest Price from Pyrazolo[1,5-a]pyridine-2-carboxylic acid manufacturers
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![Pyrazolo[1,5-a]pyridine-2-carboxylic acid pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/1a5f2de5-b013-4d9e-bdce-20141dcab3e2.jpg) |
2020-01-10 | Pyrazolo[1,5-a]pyridine-2-carboxylic acid
63237-88-7
|
1KG | 98%; 99% | 500g;1kg； 25kg | Career Henan Chemical Co |
-
- Pyrazolo[1,5-a]pyridine-2-carboxylic acid
63237-88-7
- $0.01
- 98%; 99%
- Career Henan Chemical Co
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