1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- CAS No.
- 50741-36-1
- Chemical Name:
- 1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- Synonyms
- 6-Cyano-1,2,3,4-tetrahydroquinoline;2,3,4-Tetrahydroquinoline-6-carbonitrile;1,2,3,4-Tetrahydro-6-quinolinecarbonitrile;1,2,3,4-Tetrahydroquinoline-6-carbonitrile;6-Quinolinecarbonitrile, 1,2,3,4-tetrahydro-
- CBNumber:
- CB52369548
- Molecular Formula:
- C10H10N2
- Molecular Weight:
- 158.2
- MDL Number:
- MFCD14534464
- MOL File:
- 50741-36-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933499090 |
1,2,3,4-Tetrahydroquinoline-6-carbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T304108 | 1,2,3,4-tetrahydroquinoline-6-carbonitrile | 50741-36-1 | 10mg | $45 | 2021-12-16 | Buy |
| Ark Pharm | P000351344 | 1,2,3,4-Tetrahydroquinoline-6-carbonitrile 97% | 50741-36-1 | 100mg | $73 | 2021-12-16 | Buy |
| Ark Pharm | P000351344 | 1,2,3,4-Tetrahydroquinoline-6-carbonitrile 97% | 50741-36-1 | 250mg | $117 | 2021-12-16 | Buy |
| Apolloscientific | OR928761 | 1,2,3,4-Tetrahydroquinoline-6-carbonitrile 96% | 50741-36-1 | 100mg | $160 | 2021-12-16 | Buy |
| AK Scientific | 6247BB | 1,2,3,4-Tetrahydroquinoline-6-carbonitrile | 50741-36-1 | 100mg | $170 | 2021-12-16 | Buy |
1,2,3,4-Tetrahydroquinoline-6-carbonitrile Chemical Properties,Uses,Production
Synthesis
22190-35-8
557-21-1
50741-36-1
General procedure for the synthesis of 1,2,3,4-tetrahydroquinoline-6-carbonitrile from 6-bromo-1,2,3,4-tetrahydroquinoline and zinc cyanide: To a solution of 6-bromo-1,2,3,4-tetrahydroquinoline (10 g, 47.15 mmol) in N,N-dimethylformamide (80 mL) was added tetrakis(triphenylphosphine)palladium (2.8 g, 2.42 mmol) and zinc cyanide (6.4 g, 54.49 mmol), and the reaction was stirred at 120 °C in an oil bath for 2 hours. After the reaction was completed, the reaction was quenched by adding water (400 mL), and the organic layer was extracted with dichloromethane (3×50 mL), the organic phases were combined and concentrated in vacuum to obtain the crude product. The crude product was purified by silica gel column chromatography with the eluent being a petroleum ether solution of 1%-20% ethyl acetate to afford 1,2,3,4-tetrahydroquinoline-6-carbonitrile as a yellow solid (6 g, 80% yield).LC/MS (ESI, m/z): [M + H]+ 159.1.1.1H-NMR (300 MHz, CDCl3) δ7.20-7.23 (m , 2H), 6.40 (d, J = 8.1 Hz, 1H), 3.36-3.40 (t, J = 5.7 Hz, 2H), 2.72-2.77 (t, J = 6.3 Hz, 2H), 1.90-1.97 (m, 2H).
References
[1] Patent: WO2012/94462, 2012, A2. Location in patent: Page/Page column 60-61
[2] Patent: US2004/220206, 2004, A1. Location in patent: Page 24; 32
1,2,3,4-Tetrahydroquinoline-6-carbonitrile Preparation Products And Raw materials
1,2,3,4-Tetrahydroquinoline-6-carbonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Wuxi Rejoys chemical Technology Co., Ltd. | 0510-86103381 | sales@rejoyschem.com | CHINA | 976 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24727 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Qingdao Dexin Chemical Co., Ltd | +86-15553333686 | 15553333686@qq.com | China | 3113 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 18270980682 | mlcheng@sunwaypharm.cn | China | 8669 | 57 |
