1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE
- CAS No.
- 791846-40-7
- Chemical Name:
- 1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE
- Synonyms
- tert-Butyl 4-(4-bromo-2-cyanophenyl);1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE;TERT-BUTYL 4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE-1-CARBOXYLATE;4-(4-Bromo-2-cyano-phenyl)-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(4-bromo-2-cyanophenyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB52453764
- Molecular Formula:
- C16H20BrN3O2
- Molecular Weight:
- 366.25
- MDL Number:
- MFCD09999215
- MOL File:
- 791846-40-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Boc-4-(4-Bromo-2-cyanophenyl)piperazine | 072475 | 1.00g | $105 |
| 1-Boc-4-(4-Bromo-2-cyanophenyl)piperazine | 072475 | 5.00g | $329 |
| 1-Boc-4-(4-Bromo-2-cyanophenyl)piperazine | 072475 | 10.00g | $529 |
| tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate 95+% | B58742 | 250mg | $105 |
| tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate 95+% | B58742 | 1g | $120 |
| More product size | |||
1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 072475 | 1-Boc-4-(4-Bromo-2-cyanophenyl)piperazine | 791846-40-7 | 1.00g | $105 | 2026-05-18 | Buy |
| Matrix Scientific | 072475 | 1-Boc-4-(4-Bromo-2-cyanophenyl)piperazine | 791846-40-7 | 5.00g | $329 | 2026-05-18 | Buy |
| Matrix Scientific | 072475 | 1-Boc-4-(4-Bromo-2-cyanophenyl)piperazine | 791846-40-7 | 10.00g | $529 | 2026-05-18 | Buy |
| Synthonix | B58742 | tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate 95+% | 791846-40-7 | 250mg | $105 | 2026-05-06 | Buy |
| Synthonix | B58742 | tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate 95+% | 791846-40-7 | 1g | $120 | 2026-05-06 | Buy |
1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE Chemical Properties,Uses,Production
Synthesis
179897-89-3
57260-71-6
791846-40-7
General procedure for the synthesis of 1-BOC-4-(4-bromo-2-cyanophenyl)piperazine from 2-fluoro-5-bromobenzonitrile and N-BOC-piperazine: in a pressure tube, 5-bromo-2-fluorobenzonitrile (2,500 mg, 12.5 mmol), tert-butyl piperazine-1-carboxylate (2,444.45 mg, 13.12 mmol) and triethylamine (5.23 mL. 37.5 mmol) were dissolved in dimethyl sulfoxide (10 mL) and the reaction was refluxed at 100 °C. After completion of the reaction, the mixture was cooled and separated by extraction with ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography on silica gel, eluting with a 5-60% ethyl acetate/hexane gradient to afford the light brown oily product tert-butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate (3660 mg, 80% yield).
References
[1] Patent: KR2016/37198, 2016, A. Location in patent: Paragraph 2392-2394
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 20, p. 5095 - 5098
[3] Patent: WO2017/38909, 2017, A1. Location in patent: Paragraph 0290; 0291
[4] Patent: WO2009/79593, 2009, A1. Location in patent: Page/Page column 120
1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10186 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42934 | 64 |
| SynAsst Chemical. | 021-60343070 | China | 12740 | 55 | |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189 | mychess007@163.com | China | 1994 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 17321281695 18019252918 | sale@amkchem.com | China | 14983 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 7481 | 58 |
