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Olodaterol

Olodaterol structure

CAS No.: 868049-49-4

Chemical Name:: Olodaterol

Synonyms: OLODATEROL D3;Olodaterol free base;Odaro;BI-1744;Striverdi;Olodaterol;BI 1744(Olodaterol;Striverdi Respimat);Olodaterol USP/EP/BP;Olodaterol ImpurityＡ

CBNumber:: CB52484977

Molecular Formula:: C21H26N2O5

Molecular Weight:: 386.44

MDL Number:: MFCD16619349

MOL File:: 868049-49-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:01:20

Product description	Number	Pack Size	Price
Olodaterol ≥98%	21794	1mg	$98
Olodaterol ≥98%	21794	5mg	$318
Olodaterol ≥98%	21794	10mg	$539
Olodaterol ≥98%	21794	25mg	$1225
Olodaterol ≥98%	21794	1mg	$89
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Olodaterol Properties

Boiling point	649.0±55.0 °C(Predicted)
Density	1.250
solubility	DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
form	A crystalline solid
pka	9.42±0.20(Predicted)
color	Light yellow to khaki
Stability	Hygroscopic
FDA UNII	VD2YSN1AFD
ATC code	R03AC19

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H319-H372

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P260-P264-P270-P314-P501-P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

Olodaterol price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	1mg	$98	2026-04-30	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	5mg	$318	2026-04-30	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	10mg	$539	2026-04-30	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	25mg	$1225	2026-04-30	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	1mg	$89	2024-03-01	Buy

Product number	Packaging	Price	Buy
21794	1mg	$98	Buy
21794	5mg	$318	Buy
21794	10mg	$539	Buy
21794	25mg	$1225	Buy
21794	1mg	$89	Buy

Olodaterol Chemical Properties,Uses,Production

Description

In 2013, olodaterol (also known BI-1744 CL) was approved for the treatment of chronic obstructive pulmonary disease (COPD) in Russia (March), Canada (June), and the EuropeanUnion (October). Olodaterol is delivered via the Respimat Soft Mist inhaler. Olodaterol was discovered from an effort to identify a β2-adrenergic receptor agonist that could be given once daily and with a superior safety profile over known β2- adrenergic receptor agonists. Olodaterol is a potent β2 agonist (EC₅₀=0.1 nM, intrinsic activity=88%) and is highly selective for the β2 receptor over β1 and β3 receptors. In preclinical models in guinea pigs and dogs, olodaterol had a rapid onset of action and provided bronchoprotection over 24 h. Mechanistic studies indicated that olodaterol forms a highly stable complex with the β2-adrenergic receptor, with a dissociation half-life of 17.8 h. The synthesis of olodaterol proceeds through an (R)-styrene epoxide that is prepared via enantioselective reduction of an α-chloroketone intermediate. Ring opening of the epoxide with 1-(4- methoxyphenyl)-2-methylpropan-2-amine provides olodaterol.

Originator

Boehringer-Ingelheim (European Union)

Uses

Olodaterol-d3 is labelled Olodaterol (O262000) which is a long acting b-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).

Definition

ChEBI: A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.

brand name

Striverdi

Synthesis

Synthesis of Olodaterol:2,5-dihydroxyacetophenone (2) was reacted with benzyl bromide to give 1-[2-hydroxy-5-(benzyloxy)-phenyl]ethanone (3), which was reduced to 1-[2-hydroxy-3-amino-5-(benzyloxy)phenyl]-acetophenone (5) by nitration reaction in the presence of platinum dioxide, and then by acylation, intramolecular condensation, and bromination to give 6-benzyloxy-8-( 2-bromoacetyl)-2H-benzo[b][1,4]-oxazin-3(4H)-one (7), 7 underwent asymmetric reduction and intramolecular cycloaddition to give (R)-6-benzyloxy-8-(oxiranyl-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one (8), and 8 was condensed with 1-(4-methoxyphenyl)-2-methyl-2-propanamine (9) to give 6 -Benzyloxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-benzo[b][1,4]oxazin-3(4H)-one (10), and then de-benzyl-protected to give 1 in a total yield of 16.2% (in 2). The platinum dioxide used in this method is more expensive, and the bromination reaction yield is lower (74%). (ii) Compound 2 was benzylated, nitrated, nitro-reduced, chlorinated, intramolecularly condensed, oxidized, esterified, condensed and debenzyl protected to obtain Olodaterol. The target product obtained by this method was the racemate of Olodaterol, which was not a single-configuration target product.

Olodaterol synthesis

Synthesis of Olodaterol from 8-[(1R)-1-Hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one

Olodaterol Preparation Products And Raw materials

Raw materials

8-[(1R)-1-Hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one 6-benzyloxy-8-((R)-2-chloro-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one

Preparation Products

Olodaterol Suppliers

Global( 98)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Hebei Miaobian Biotechnology Co., Ltd	+8617733850068		CHINA	967	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9653	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Hebei Shengyuan Jinlong Import and Export Co. LTD	+8617367750398	info@hebeisyjl.com	China	1838	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hebei Miaobian Biotechnology Co., Ltd	58
changzhou huayang technology co., ltd	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hebei Shengyuan Jinlong Import and Export Co. LTD	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

View Lastest Price from Olodaterol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-20	olodaterol 868049-49-4	$50.00	1KG	0.99	10000	Hebei Yanxi Chemical Co., Ltd.
2021-07-13	Olodaterol 868049-49-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Olodaterol 868049-49-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

olodaterol
868049-49-4
$50.00
0.99
Hebei Yanxi Chemical Co., Ltd.

Olodaterol
868049-49-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Olodaterol
868049-49-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Olodaterol Spectrum

Olodaterol(868049-49-4)¹HNMR

868049-49-4(Olodaterol)Related Search:

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1of4

6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one 2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]- BI 1744(Olodaterol Striverdi Respimat) BI-1744 Striverdi Olodaterol, 98%, a long acting β2-adrenoceptor agonist Olodaterol Olodaterol ImpurityＡ　 Olodaterol free base OLODATEROL;BI-1744;STRIVERDI Olodaterol, 6-Hydroxy-8-[(1r)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2h-1,4-benzoxazin-3(4h)-one STRIVERDI RESPIMAT; BI 1744; BI1744 (R)-6-hydroxy-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 6 - hydroxy - 8 - [(1 r) - 1 - hydroxy - 2 - [[2 - (4 - methoxy phenyl) - 1, 1-2 methyl ethyl] amino] ethyl] - 2 h - 1, 4 - benzo oxazine - 3 (4 h) - one Olodaterol USP/EP/BP Olodaterol Discontinued Olodaterol D3 HydrochlorideQ: What is Olodaterol D3 Hydrochloride Q: What is the CAS Number of Olodaterol D3 Hydrochloride Q: What are the applications of Olodaterol D3 Hydrochloride 6-hydroxy-8-(1-hydroxy-2-((2-(4-methoxyphenyl)-1,1-dimethylethyl)amino)ethyl)-2H-1,4-benzoxazin-3(4H)-one Odaro OLODATEROL D3 868049-49-4