3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
- CAS No.
- 858643-92-2
- Chemical Name:
- 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
- Synonyms
- tert-butyl 3-acetylpiperidine-1-carboxylate;1-Boc-3-acetylpiperidine;1-Boc-3-acetylpiperidine - [A13489];1,1-Dimethylethyl 3-acetyl-1-piperidinecarboxylate;3-Acetyl-1-piperidinecarboxylic acid tert-butyl ester;3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 3-acetyl-, 1,1-dimethylethyl es...;1-Piperidinecarboxylic acid, 3-acetyl-, 1,1-diMethylethyl ester
- CBNumber:
- CB52506466
- Molecular Formula:
- C12H21NO3
- Molecular Weight:
- 227.3
- MDL Number:
- MFCD09953372
- MOL File:
- 858643-92-2.mol
- MSDS File:
- SDS
| Boiling point | 312.4±35.0 °C(Predicted) |
|---|---|
| Density | 1.052 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -2.40±0.40(Predicted) |
| Appearance | Colorless to off-white Solid |
| InChI | InChI=1S/C12H21NO3/c1-9(14)10-6-5-7-13(8-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3 |
| InChIKey | IIDISJMZFQAYKG-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCCC(C(C)=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HS Code | 2933399990 |
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IJB64392 | tert-Butyl 3-acetylpiperidine-1-carboxylate | 858643-92-2 | 25g | $295 | 2026-06-04 | Buy |
| Matrix Scientific | 123520 | 1-Boc-3-acetylpiperidine | 858643-92-2 | 1.00g | $594 | 2026-05-18 | Buy |
| Synthonix | A13489 | 1-Boc-3-acetylpiperidine 95+% | 858643-92-2 | 1g | $26 | 2026-05-06 | Buy |
| Synthonix | A13489 | 1-Boc-3-acetylpiperidine 95+% | 858643-92-2 | 5g | $50 | 2026-05-06 | Buy |
| Synthonix | A13489 | 1-Boc-3-acetylpiperidine 95+% | 858643-92-2 | 10g | $80 | 2026-05-06 | Buy |
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production
Synthesis
75-16-1
![1-Boc-3-[methoxy(methyl)carbamoyl]piperidine](/CAS/GIF/189442-78-2.gif)
189442-78-2
858643-92-2
Methylmagnesium bromide (1.4 M toluene/THF 75/25, 268 mL) was slowly added dropwise to a solution of 1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide (59 g, 0.22 mol) in tetrahydrofuran (THF, 250 mL) at 0 °C and protected by nitrogen, and the temperature of the reaction was controlled not to exceed 15 °C. After dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was slowly poured into an ice-water mixture containing 100 mL of ice-acetic acid. The product was extracted with ether (Et2O) and the organic layer was washed with 5% sodium bicarbonate (NaHCO3) solution. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give tert-butyl 3-acetylpiperidine-1-carboxylate (50 g, quantitative yield).
References
[1] Patent: WO2018/154133, 2018, A1. Location in patent: Page/Page column 48
[2] Patent: US2006/183761, 2006, A1. Location in patent: Page/Page column 27
[3] Journal of Organic Chemistry, 2009, vol. 74, # 5, p. 1932 - 1938
[4] Patent: WO2010/36589, 2010, A1. Location in patent: Page/Page column 62
[5] Patent: WO2012/58127, 2012, A2. Location in patent: Page/Page column 80
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 427 | 60 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4565 | 58 |
View Latest Price from 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
858643-92-2
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co | |
 |
2020-01-09 | 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
858643-92-2
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
-
- 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
858643-92-2
- $1.00
- 95-99%
- Career Henan Chemical Co
-
- 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
858643-92-2
- $1.00
- 99%
- Career Henan Chemical Co
