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ChemicalBook >> CAS DataBase List >>2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Structure
2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine structure
CAS No.
1052686-60-8
Chemical Name:
2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Synonyms
2-Methoxypyrimidine-5-boronic acid pinacol ester;2-Methoxypyrimidin-5-ylboronic acid pinacol ester;2-methoxypyrimidine-5-boronic acid frequency which ol ester;2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine;Pyrimidine, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine ISO 9001：2015 REACH
CBNumber:
CB52515604
Molecular Formula:
C11H17BN2O3
Molecular Weight:
236.08
MDL Number:
MFCD13182190
MOL File:
1052686-60-8.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:43
Product description Number Pack Size Price
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine M333168 50mg $90
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine M333168 25mg $65
2-Methoxypyrimidin-5-ylboronic acid, pinacol ester OR361403 250mg $137
2-Methoxypyrimidin-5-ylboronicacidpinacolester Z6794 1g $491
2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDINE 95.00% BOR0006456 5MG $498.84
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2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Properties

Boiling point 354.3±34.0 °C(Predicted)
Density 1.10±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 0.94±0.22(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335-H302
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
HS Code  2933599590

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M333168 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 1052686-60-8 50mg $90 2021-12-16 Buy
TRC M333168 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 1052686-60-8 25mg $65 2021-12-16 Buy
Apolloscientific OR361403 2-Methoxypyrimidin-5-ylboronic acid, pinacol ester 1052686-60-8 250mg $137 2021-12-16 Buy
AK Scientific Z6794 2-Methoxypyrimidin-5-ylboronicacidpinacolester 1052686-60-8 1g $491 2021-12-16 Buy
American Custom Chemicals Corporation BOR0006456 2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDINE 95.00% 1052686-60-8 5MG $498.84 2021-12-16 Buy
Product number Packaging Price Buy
M333168 50mg $90 Buy
M333168 25mg $65 Buy
OR361403 250mg $137 Buy
Z6794 1g $491 Buy
BOR0006456 5MG $498.84 Buy

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Chemical Properties,Uses,Production

Synthesis

Bis(pinacolato)diboron

73183-34-3

5-Bromo-2-methoxypyrimidine

14001-66-2

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

1052686-60-8

A solvent mixture (DME/H2O/Toluene/EtOH = 10:1:6:7, 7 mL) of 5-bromo-2-methoxypyrimidine (800 mg, 4.26 mmol) and potassium acetate (1.25 g, 12.77 mmol) was added to the reaction vial. Pd(dppf)Cl2-DCM (700 mg, 0.85 mmol) and bis(pinacolato)diboron (2.44 g, 9.6 mmol) were subsequently added. The reaction mixture was degassed and replaced three times with nitrogen before the reaction was stirred at 85 °C overnight. The reaction progress was monitored by TLC and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. The mixture was diluted with water (10 mL) and extracted with ethyl acetate (30 mL × 3). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated. Purification by silica gel column chromatography (eluent ratio PE:EA = 5:1) afforded the target product 2-methoxypyrimidine-5-boronic acid pinacol ester (24-4) as a yellow solid (1.0 g, 98% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 19, p. 5849 - 5853
[2] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 290
[3] Patent: WO2017/197151, 2017, A1. Location in patent: Page/Page column 40

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Preparation Products And Raw materials

Raw materials

Bis(pinacolato)diboron 5-Bromo-2-methoxypyrimidine Toluene Water 1,2-Dimethoxyethane
Potassium Acetate Ethanol

1of2

Preparation Products

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Suppliers

Global( 80)Suppliers
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Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 10000 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9333 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49968 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Henan Aochuang Chemical Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58

View Lastest Price from 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine pictures 2025-06-25 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
1052686-60-8
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine pictures 2025-04-04 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
1052686-60-8
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine pictures 2020-01-10 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
1052686-60-8
 US $1.00 / KG 1g 98% 200kgs Career Henan Chemical Co

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Spectrum

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine(1052686-60-8)1HNMR

1052686-60-8(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine)Related Search:

Phenylboronic acid 2-Methoxyquinoline-3-boronic acid
2-Methoxypyrimidin-5-ylboronic acid pinacol ester 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 2-Methoxypyrimidine-5-boronic acid pinacol ester Pyrimidine, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine ISO 9001：2015 REACH 2-methoxypyrimidine-5-boronic acid frequency which ol ester 1052686-60-8