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WAY-600

WAY-600 Structure
WAY-600 structure
CAS No.
1062159-35-6
Chemical Name:
WAY-600
Synonyms
WAY-600;WAY-600;WAY 600;WAY-600 USP/EP/BP;Anti-CSCs agent-1;WAY-600, 10 mM in DMSO;6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine;4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine;6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine;4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine;1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-
CBNumber:
CB52561500
Molecular Formula:
C28H30N8O
Molecular Weight:
494.59
MDL Number:
MFCD22419019
MOL File:
1062159-35-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
WAY-600 ≥98% 29214 1mg $98
WAY-600 ≥98% 29214 5mg $363
WAY-600 ≥98% 29214 10mg $481
WAY-600 99.86% CS-6895 2mg $143
WAY-600 99.86% CS-6895 5mg $247
Request For Quotation

WAY-600 Properties

Density 1.43
storage temp. Store at -20°C
solubility Soluble in DMSO > 10 mM
form Powder
pka 16.08±0.30(Predicted)
color White to off-white

WAY-600 price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29214 WAY-600 ≥98% 1062159-35-6 1mg $98 2026-04-30 Buy
Cayman Chemical 29214 WAY-600 ≥98% 1062159-35-6 5mg $363 2026-04-30 Buy
Cayman Chemical 29214 WAY-600 ≥98% 1062159-35-6 10mg $481 2026-04-30 Buy
ChemScene CS-6895 WAY-600 99.86% 1062159-35-6 2mg $143 2026-06-04 Buy
ChemScene CS-6895 WAY-600 99.86% 1062159-35-6 5mg $247 2026-06-04 Buy
Product number Packaging Price Buy
29214 1mg $98 Buy
29214 5mg $363 Buy
29214 10mg $481 Buy
CS-6895 2mg $143 Buy
CS-6895 5mg $247 Buy

WAY-600 Chemical Properties,Uses,Production

Uses

WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for recombinant mTOR enzyme. WAY-600 blocks mTOR complex 1/2 (mTORC1/2) assemble and activation.

Biological Activity

WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with IC50 of 9 nM for recombinant mTOR enzyme. It blocks mTOR complex 1/2 (mTORC1/2) assembly and activation.

in vitro

WAY-600 decreased exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically . Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. It dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association ) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).

in vivo

Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, po daily).

target

mTOR

9 nM (IC 50 )

mTORC1

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mTORC2

PI3K alpha

1.96 μM (IC 50 )

PI3K gamma

8.45 μM (IC 50 )

IC 50

mTOR: 9 nM (IC50); mTORC1; mTORC2; PI3K alpha: 1.96 μM (IC50); PI3K gamma: 8.45 μM (IC50)

References

[1] Yu K, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res. 2009 Aug 1;69(15):6232-40. DOI:10.1158/0008-5472.CAN-09-0299
[2] Wang K, et al. MEK-ERK inhibition potentiates WAY-600-induced anti-cancer efficiency in preclinical hepatocellular carcinoma (HCC) models. Biochem Biophys Res Commun. 2016 May 27;474(2):330-7. DOI:10.1016/j.bbrc.2016.04.099

WAY-600 Preparation Products And Raw materials

Raw materials

Preparation Products

WAY-600 Suppliers

Global( 109)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Career Henan Chemica Co 		+86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29096 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10378 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6378 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+86-0086-13720134139 orders@jknbiochem.com China 5215 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58

View Lastest Price from WAY-600 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WAY-600 pictures 2026-07-27 WAY-600
1062159-35-6
 $35.00-86.00 99.88% 10g TargetMol Chemicals Inc.
  • WAY-600 pictures
  • WAY-600
    1062159-35-6
  • $35.00-86.00
  • 99.88%
  • TargetMol Chemicals Inc.

WAY-600 Spectrum

WAY-600(1062159-35-6)1HNMR

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1of4

WAY-600 6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine 6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine WAY-600;WAY 600 4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine 1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]- WAY-600 USP/EP/BP 4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine WAY-600, 10 mM in DMSO Anti-CSCs agent-1 1062159-35-6 C28H30N8O Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR