4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride
- CAS No.
- 666261-01-4
- Chemical Name:
- 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride
- Synonyms
- 4-(aminomethyl)oxan-4-ol hydrochloride;tetrahydro-2H-pyran-4-ol hydrochloride;4-(Aminomethyl)tetrahydro-2h-pyran-4-ol HCl;4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride;4-(aminomethyl)tetrahydro-1H-pyran-4-ol hydrochloroide
- CBNumber:
- CB52566914
- Molecular Formula:
- C6H14ClNO2
- Molecular Weight:
- 167.63386
- MDL Number:
- MFCD18072019
- MOL File:
- 666261-01-4.mol
| Product description | Number | Pack Size | Price |
| 4-Aminomethyltetrahydro-4H-pyran-4-olHydrochloride | A622716 | 250mg | $100 |
| 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride | FA141840 | 2g | $210 |
| 4-(Aminomethyl)tetrahydro-2H-pyran-4-olhydrochloride | W7753 | 1g | $211 |
| 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride | FA141840 | 1g | $135 |
| 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride 97% | P000377503 | 250mg | $140 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2932990090 |
4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A622716 | 4-Aminomethyltetrahydro-4H-pyran-4-olHydrochloride | 666261-01-4 | 250mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA141840 | 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride | 666261-01-4 | 2g | $210 | 2021-12-16 | Buy |
| AK Scientific | W7753 | 4-(Aminomethyl)tetrahydro-2H-pyran-4-olhydrochloride | 666261-01-4 | 1g | $211 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA141840 | 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride | 666261-01-4 | 1g | $135 | 2021-12-16 | Buy |
| Ark Pharm | P000377503 | 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride 97% | 666261-01-4 | 250mg | $140 | 2021-12-16 | Buy |
4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride Chemical Properties,Uses,Production
Uses
4-Aminomethyltetrahydro-4H-pyran-4-ol Hydrochloride is a reagent used in the preparation of aminopyrimidinecarboxamides and their use as CB2-type cannabinoid receptor modulators.
Synthesis
50289-10-6
666261-01-4
LiAlH4 (18.7 g, 492 mmol) was added to a 2 L three-necked round-bottomed flask equipped with a top stirrer, thermocouple, dropping funnel, and nitrogen inlet and cooled to 0 °C, followed by the addition of anhydrous THF. 4-Hydroxytetrahydro-2H-pyran-4-carbonitrile (25.0 g, 196 mmol) was slowly added dropwise to the reaction mixture over a period of 1 h. The reaction was carried out in a 250 mL) solution. After the dropwise addition, the reaction mixture was warmed to room temperature and the dropping funnel was replaced with a reflux condenser and heated to reflux at 70 °C for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and further cooled to -10 °C in a dry ice acetone bath, followed by quenching the reaction with 2N NaOH solution (150 mL) until a white precipitate appeared. The reaction mixture was warmed to room temperature, diluted with ethyl acetate (500 mL) and stirred for 10 minutes. The precipitated solid was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed with ethyl acetate (300 mL). The filtrate was concentrated under reduced pressure to give a gelatinous liquid, which was dissolved in methyl tert-butyl ether (MTBE, 100 mL) and cooled to 0°C. A dioxane solution (100 mL) in 4N HCl was added dropwise to this solution and stirred at 0 °C for 30 min, followed by continued stirring at room temperature for 30 min. The precipitated solid was collected by vacuum filtration and dried over a constant flow of N2 gas to afford the target product 4-(aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride (21.0 g, 64% yield) as an off-white solid; Mass Spectrum (MS): m/z = 132 (M+H+).
References
[1] Patent: US2009/76062, 2009, A1. Location in patent: Page/Page column 22-23
[2] Patent: WO2005/74939, 2005, A1. Location in patent: Page/Page column 43-44; 62
[3] Patent: US2017/217986, 2017, A1. Location in patent: Paragraph 0513; 0514
[4] Patent: WO2004/29026, 2004, A1. Location in patent: Page 30-31
[5] Patent: WO2004/18433, 2004, A1. Location in patent: Page 54
4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | +86 028-84641798 15982321820 | abby@arkpharm.com | China | 9993 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-029-81120477 17792793610 | 1033@dideu.com | China | 9970 | 58 |
View Lastest Price from 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-14 | 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride
666261-01-4
|
US $7.00 / KG | 1KG | 99% | 1000kg | Career Henan Chemical Co |
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- 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride
666261-01-4
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
