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JTE-013

JTE-013 structure

CAS No.: 383150-41-2

Chemical Name:: JTE-013

Synonyms: CS-2553;JTE-013 HCl;JTE 013 ，S7182;JTE-013;JTE 013;JTE013;JTE-013, 10 mM in DMSO;LPL Receptor,Apoptosis,JTE-013,Inhibitor,Lysophospholipid Receptor,JTE 013,inhibit,JTE013;1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide

CBNumber:: CB52591408

Molecular Formula:: C17H19Cl2N7O

Molecular Weight:: 408.29

MDL Number:: MFCD09878275

MOL File:: 383150-41-2.mol

MSDS File:: SDS

Last updated:2026-01-13 11:23:02

Product description	Number	Pack Size	Price
JTE-013 ≥98% (HPLC)	J4080	5mg	$151.05
JTE-013 ≥98% (HPLC)	J4080	25mg	$441
JTE-013 ≥98%	10009458	1mg	$26
JTE-013 ≥98%	10009458	5mg	$98
JTE-013 ≥98%	10009458	10mg	$135
More product size

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JTE-013 Properties

Density	1.50±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥20mg/mL
pka	9.32±0.43(Predicted)
form	powder
color	white to off-white
InChI	1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)
InChIKey	RNSLRQNDXRSASX-UHFFFAOYSA-N
SMILES	Clc1nc(cc(c1)NC(=O)NNc2nc3[n](nc(c3c(c2)C(C)C)C)C)Cl
UNSPSC Code	12352211
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P301+P310

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

NFPA 704

	0
2		0

JTE-013 price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	J4080	JTE-013 ≥98% (HPLC)	383150-41-2	5mg	$151.05	2025-07-31	Buy
Sigma-Aldrich	J4080	JTE-013 ≥98% (HPLC)	383150-41-2	25mg	$441	2025-07-31	Buy
Cayman Chemical	10009458	JTE-013 ≥98%	383150-41-2	1mg	$26	2024-03-01	Buy
Cayman Chemical	10009458	JTE-013 ≥98%	383150-41-2	5mg	$98	2024-03-01	Buy
Cayman Chemical	10009458	JTE-013 ≥98%	383150-41-2	10mg	$135	2024-03-01	Buy

Product number	Packaging	Price	Buy
J4080	5mg	$151.05	Buy
J4080	25mg	$441	Buy
10009458	1mg	$26	Buy
10009458	5mg	$98	Buy
10009458	10mg	$135	Buy

JTE-013 Chemical Properties,Uses,Production

Description

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P₁/EDG-1, S1P₂/EDG-5, S1P₃/EDG-3, S1P₄/EDG-6, and S1P₅/EDG-8. JTE-013 is a potent, selective sphingosine-1-phosphate 2 (S1P₂) receptor antagonist that binds to the human and rat receptors with IC₅₀ values of 17 and 22 nM, respectively, (IC₅₀ values >10 μM for human S1P₁ and S1P₃). It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells. JTE-013 inhibits S1P-induced contraction of, as well as cyclic AMP accumulation in, coronary artery smooth muscle cells.

Uses

JTE-013 has been used in in vitro blood?brain barrier (BBB) and blood?tumor barrier (BTB) assays.

Definition

ChEBI: 1-(2,6-dichloro-4-pyridinyl)-3-[(1,3-dimethyl-4-propan-2-yl-6-pyrazolo[3,4-b]pyridinyl)amino]urea is a pyrazolopyridine.

Biochem/physiol Actions

JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.

storage

Store at +4°C

References

[1] MELISSA R PITMAN. The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.[J]. Scientific Reports, 2022: 454. DOI: 10.1038/s41598-021-04009-w
[2] MAKOTO OSADA. Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist[J]. Biochemical and biophysical research communications, 2002, 299 3: Pages 483-487. DOI: 10.1016/s0006-291x(02)02671-2
[3] KAYO ARIKAWA. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity.[J]. The Journal of Biological Chemistry, 2003, 278 35: 32841-32851. DOI: 10.1074/jbc.m305024200
[4] QIUMIN XU BMED . JTE-013 Alleviates Inflammatory Injury and Endothelial Dysfunction Induced by Sepsis In Vivo and In Vitro[J]. Journal of Surgical Research, 2021, 265: Pages 323-332. DOI: 10.1016/j.jss.2021.03.006
[5] MENGDIE WANG. Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing[J]. Clinical and Experimental Pharmacology and Physiology, 2021, 48 8: 1080-1089. DOI: 10.1111/1440-1681.13460
[6] STEPHANIE S DUSABAN. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.[J]. Journal of Neuroinflammation, 2017: 111. DOI: 10.1186/s12974-017-0882-x
[7] NADINE AL ALAM Sawsan I K. FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2.[J]. Biochemistry and Cell Biology, 2016, 94 4: 371-377. DOI: 10.1139/bcb-2016-0025

JTE-013 Preparation Products And Raw materials

Raw materials

Preparation Products

JTE-013 Suppliers

Global( 93)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43339	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Alfa Chemistry	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58
Aladdin Scientific	58

View Lastest Price from JTE-013 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-01-09	JTE-013 383150-41-2	US $70.00-224.00 / mg		99.65%	10g	TargetMol Chemicals Inc.

JTE-013
383150-41-2
US $70.00-224.00 / mg
99.65%
TargetMol Chemicals Inc.

JTE-013 Spectrum

JTE-013(383150-41-2)¹HNMR

1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide 1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide CS-2553 N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide JTE-013;JTE 013;JTE013 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea Hydrazinecarboxamide, N-(2,6-dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]- N-(2,6-Dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide JTE-013 HCl LPL Receptor,Apoptosis,JTE-013,Inhibitor,Lysophospholipid Receptor,JTE 013,inhibit,JTE013 N-(2,6-Dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide , JTE-013 JTE-013, 10 mM in DMSO JTE 013 ，S7182 383150-41-2 C17H19Cl2N7O