Methyl 4-chloro-5-Methylpicolinate
- CAS No.
- 1104455-41-5
- Chemical Name:
- Methyl 4-chloro-5-Methylpicolinate
- Synonyms
- Methyl 4-chloro-5-Methylpicolinate;Methyl 4-chloro-5-methylpyridine-2-carboxylate;4-Chloro-5-methylpyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 4-chloro-5-methyl-, methyl ester
- CBNumber:
- CB52605231
- Molecular Formula:
- C8H8ClNO2
- Molecular Weight:
- 185.61
- MDL Number:
- MFCD16987786
- MOL File:
- 1104455-41-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Methyl 4-chloro-5-Methylpicolinate price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 126548 | Methyl 4-chloro-5-methylpicolinate | 1104455-41-5 | 100.00mg | $79 | 2026-05-18 | Buy |
| Matrix Scientific | 126548 | Methyl 4-chloro-5-methylpicolinate | 1104455-41-5 | 250.00mg | $110 | 2026-05-18 | Buy |
| Matrix Scientific | 126548 | Methyl 4-chloro-5-methylpicolinate | 1104455-41-5 | 1.00g | $275 | 2026-05-18 | Buy |
| Synthonix | M16577 | Methyl 4-chloro-5-methylpyridine-2-carboxylate 97.0% | 1104455-41-5 | 50mg | $77 | 2026-05-06 | Buy |
| Synthonix | M16577 | Methyl 4-chloro-5-methylpyridine-2-carboxylate 97.0% | 1104455-41-5 | 100mg | $90 | 2026-05-06 | Buy |
Methyl 4-chloro-5-Methylpicolinate Chemical Properties, Uses, Production
Synthesis
67-56-1
4434-13-3
1104455-41-5
1. 5-methylpyridine carboxylic acid (13.7 g) was mixed with thionyl chloride (150 mL) under nitrogen protection, sodium bromide (20.6 g) was added in batches and heated to reflux for 1 hour. 2. DMF (2 mL) was added and refluxing continued under nitrogen protection for 16 hours. 3. Toluene (100 mL) was added to the reaction mixture and the solvent was evaporated under reduced pressure, this operation was repeated twice. Subsequently, toluene (100 mL) was added to the residue. 4. DIPEA (25.8 g) and methanol (20 mL) were added to the above mixture under nitrogen protection and at 0 °C, followed by stirring at 20 °C for 2 hours. 5. The solvent was evaporated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether) to afford methyl 4-chloro-5-methylpyridinecarboxylate (9.40g). 6. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 2.43 (3H, s), 3.99 (3H, s), 8.10 (1H, s), 8.54 (1H, s).
References
[1] Patent: EP3156397, 2017, A1. Location in patent: Paragraph 0267
[2] Patent: WO2018/89261, 2018, A2. Location in patent: Paragraph 0932; 0933; 0934
Methyl 4-chloro-5-Methylpicolinate Preparation Products And Raw materials
Methyl 4-chloro-5-Methylpicolinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai Taibao Pharmaceutical Technology Co., Ltd. | 13816752554 | 1745533547@qq.com | China | 128 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Taian Jiaye Biotechnology Co.Ltd | 15318151873;13127280945 | 285424065@qq.com | China | 9961 | 55 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 6746 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
