Methyl 2-(3-oxocyclobutyl)acetate
- CAS No.
- 1148130-30-6
- Chemical Name:
- Methyl 2-(3-oxocyclobutyl)acetate
- Synonyms
- ethyl 2-(3-oxocyclobutyl)acetate;Methyl 2-(3-oxocyclobutyl);Methyl 2-(3-oxocyclobutyl)acetate;Cyclobutaneacetic acid, 3-oxo-, methyl ester
- CBNumber:
- CB52614848
- Molecular Formula:
- C7H10O3
- Molecular Weight:
- 142.15
- MDL Number:
- MFCD20134006
- MOL File:
- 1148130-30-6.mol
- MSDS File:
- SDS
| Boiling point | 205.7±13.0 °C(Predicted) |
|---|---|
| Density | 1.136±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| Appearance | colorless liquid |
| InChI | InChI=1S/C7H10O3/c1-10-7(9)4-5-2-6(8)3-5/h5H,2-4H2,1H3 |
| InChIKey | UJPOOJZMVQMLOM-UHFFFAOYSA-N |
| SMILES | C1(CC(OC)=O)CC(=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2916200090 |
Methyl 2-(3-oxocyclobutyl)acetate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR932724 | Methyl 2-(3-oxocyclobutyl)acetate ≥95% | 1148130-30-6 | 500mg | $698 | 2026-06-04 | Buy |
| Apolloscientific | OR932724 | Methyl 2-(3-oxocyclobutyl)acetate ≥95% | 1148130-30-6 | 1g | $1033 | 2026-06-04 | Buy |
| Matrix Scientific | 120069 | Methyl 2-(3-oxocyclobutyl)acetate | 1148130-30-6 | 250.00mg | $71 | 2026-05-18 | Buy |
| Matrix Scientific | 120069 | Methyl 2-(3-oxocyclobutyl)acetate | 1148130-30-6 | 1.00g | $189 | 2026-05-18 | Buy |
| Matrix Scientific | 120069 | Methyl 2-(3-oxocyclobutyl)acetate | 1148130-30-6 | 5.00g | $733 | 2026-05-18 | Buy |
Methyl 2-(3-oxocyclobutyl)acetate Chemical Properties, Uses, Production
Synthesis
1148130-29-3
1148130-30-6
Methyl 2-(2,2-dichloro-3-oxocyclobutyl)acetate (0.6 g) was used as raw material, which was dissolved in acetic acid (5 mL) and zinc powder (0.929 g) was added. The reaction mixture was stirred at 100 °C for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate, and subsequently carefully neutralized with ice-cold saturated aqueous sodium bicarbonate solution at 0 °C. The aqueous phase was separated, extracted with ethyl acetate, the organic phases were combined and washed with saturated aqueous sodium bicarbonate solution. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by column chromatography on 40 g silica gel using a 20-minute gradient of 0-90% ethyl acetate/hexane solution as eluent, resulting in methyl 2-(3-oxocyclobutyl)acetate (0.27 g). The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts of 3.63 (3H, s), 3.12-3.27 (2H, m), 2.68-2.81 (3H, m), 2.56-2.64 (2H, m).
References
[1] Patent: US2009/118287, 2009, A1. Location in patent: Page/Page column 74-75
[2] Patent: US2013/183269, 2013, A1. Location in patent: Paragraph 1332; 1333
[3] Patent: WO2015/5901, 2015, A1. Location in patent: Page/Page column 540; 541
Methyl 2-(3-oxocyclobutyl)acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Xuentian Technology Co.,Ltd. | +86-186 6172 2072; 18661722072 | mk@xuentian.cn | China | 250 | 58 |
| Shanghai Shanyuan pharmaceutical technology co., LTD | 021-31761238 13167072949 | 3146446224@qq.com | China | 1420 | 55 |
| Anqing Rong Chuang Biological Technology Co., Ltd. | 15001988657 | Sales_zhao@bookchemicals.com | China | 981 | 58 |
| Shanghai Linuo Pharmaceutical Technology Co., LTD | 13486628501 | 3481904551@qq.com | China | 438 | 58 |
| Selection Bioscience LLC | 18280071318 18621190837 | hr@selectionbio.com | China | 84 | 58 |
| Hangzhou Copiore Chemical Co., Ltd. | 17300981287 13757145729 | sales@copiore.com | China | 291 | 58 |
| Chengdu NoVi Biotechnology Co., Ltd. | 028-81458053 | novibiotech@163.com sales@novi-biotech.com | China | 226 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
