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Trelagliptin

Trelagliptin structure

CAS No.: 865759-25-7

Chemical Name:: Trelagliptin

Synonyms: Trilagliptin;YR-472;CS-926;Zafatek);Trelagliplin;Trelagliptin;Glass acid trigram;Trelagliptin, >=98%;SYR472 Trelagliptin;13C,D3-Trelagliptin

CBNumber:: CB52628490

Molecular Formula:: C18H20FN5O2

Molecular Weight:: 357.38

MDL Number:: MFCD22572746

MOL File:: 865759-25-7.mol

MSDS File:: SDS

Last updated:2026-03-06 11:42:52

Product description	Number	Pack Size	Price
Trelagliptin ≥98%	18504	1mg	$62
Trelagliptin ≥98%	18504	5mg	$270
Trelagliptin ≥98%	18504	10mg	$388
Trelagliptin	T718780	10mg	$375
(S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile	A627965	2.5mg	$430
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Trelagliptin Properties

Boiling point	519.0±60.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form	solid
pka	9.88±0.20(Predicted)
color	White to off-white
InChI	InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey	IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES	C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1
FDA UNII	Q836OWG55H

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

Trelagliptin price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18504	Trelagliptin ≥98%	865759-25-7	1mg	$62	2024-03-01	Buy
Cayman Chemical	18504	Trelagliptin ≥98%	865759-25-7	5mg	$270	2024-03-01	Buy
Cayman Chemical	18504	Trelagliptin ≥98%	865759-25-7	10mg	$388	2024-03-01	Buy
TRC	T718780	Trelagliptin	865759-25-7	10mg	$375	2021-12-16	Buy
TRC	A627965	(S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile	865759-25-7	2.5mg	$430	2021-12-16	Buy

Product number	Packaging	Price	Buy
18504	1mg	$62	Buy
18504	5mg	$270	Buy
18504	10mg	$388	Buy
T718780	10mg	$375	Buy
A627965	2.5mg	$430	Buy

Trelagliptin Chemical Properties,Uses,Production

Uses

Trelagliptin is a highly selective, long-acting dipeptidyl peptidase IV (DPP-4) inhibitor. This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.

Definition

ChEBI: Trelagliptin is a member of benzenes and a nitrile.

Biological Activity

trelagliptin (syr-472) is a selective inhibitor of dpp-4 and is developed for the treatment of type 2 diabetes mellitus (t2dm) [1].dipeptidyl peptidase (dpp)-4 also known as adenosine deaminase complexing protein 2 or cd26 is an antigenic enzyme that expressed on the surface of most cell types and plays an important role in regulating immune system, signal transduction and apoptosis [2, 3].trelagliptin (syr-472) is a potent dpp-4 inhibitor and can be administered once weekly which unlike its other class approved agents that be taken once daily [1]. in japan,

in vivo

Trelagliptin (oral gavage; 7 mg/kg; single dose) shows sustained PD effect in dogs and gives >80% inhibition of DPP-4 activity even after 24h^[1].Trelagliptin (oral gavage; 3 mg/kg; single dose; 60 min prior to oral glucose) significantly improves the glucose tolerance capacity by decreasing the AUC_0120min of 19.3% compared with the vehicle group in ob/ob mice^[3]. Trelagliptin (oral gavage; 10 mg/kg; once a week; 8 weeks) caused significant reductions in fasting blood glucose (FBG) levels, and the average reduction during the entire treatment period is 16.8% compared to the control.It also increases insulin level and raised it by 1.7-fold in AUC_0120min in ob/ob mice^[3].

Animal Model:	ICR ob/ob mice^[3]
Dosage:	10 mg/kg
Administration:	Oral gavage; 10 mg/kg; once a week; 8 weeks
Result:	Exerted chronic antidiabetic effects on type 2 diabetic db/db Mice.

target

DPP-4

IC 50

DPP-4

References

[1]. mckeage, k., trelagliptin: first global approval. drugs, 2015. 75(10): p. 1161-4.
[2]. inagaki, n., et al., once-weekly trelagliptin versus daily alogliptin in japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study. lancet diabetes endocrinol, 2015. 3(3): p. 191-7.
[3]. inagaki, n., et al., syr-472, a novel once-weekly dipeptidyl peptidase-4 (dpp-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. lancet diabetes endocrinol, 2014. 2(2): p. 125-32.

Trelagliptin Preparation Products And Raw materials

Raw materials

Preparation Products

Trelagliptin Suppliers

Global( 256)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.	+86-029-86185165 +8618629664246	guoyuan@eastchinapharm.com	China	1615	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8496	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Jinan Jianfeng Chemical Co., Ltd	+86-0531-88110457 +8615562555968	info@pharmachemm.com	China	308	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58

Supplier	Advantage
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Lianyungang happen teng technology co., LTD	58
career henan chemical co	58
Jinan Jianfeng Chemical Co., Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58

View Lastest Price from Trelagliptin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-05	Trelagliptin 865759-25-7	US $66.00-101.00 / mg		98.94%	10g	TargetMol Chemicals Inc.
2025-06-03	Trelagliptin 865759-25-7	US $65.00-650.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd
2025-04-04	Trelagliptin 865759-25-7	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

Trelagliptin
865759-25-7
US $66.00-101.00 / mg
98.94%
TargetMol Chemicals Inc.

Trelagliptin
865759-25-7
US $65.00-650.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

Trelagliptin
865759-25-7
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Trelagliptin Spectrum

Trelagliptin(865759-25-7)¹HNMR

865759-25-7(Trelagliptin)Related Search:

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Trelagliptin Impurity 20 Trelagliptin IMpurity Icotinib Saxagliptin Pregabalin

Ibrutinib Metformin Troglitazone Sofosbuvir Entospletinib (GS-9973)

NVP-ADW742 ABT 263 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

1of4

Trelagliptin(syr472) Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro- Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile (S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile Trelagliptin Isomer Impurity Trelagliptin, >=98% Trelagliptin free base Trelagliptin 1-(2-broMo-5-fluorobenzyl)-6-chloro-3-MethylpriMidine-2,4(1H, 3H)-dione Trelagliplin (R)-2-[[6-(3-AMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl]Methyl]-4-fluorobenzonitrile Trelagliptin impurity G YR-472 (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin) (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2 4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin) CS-926 SYR472 Trelagliptin SYR-472; SYR472; SYR 472 Glass acid trigram Trelagliptin Impurity 83 Trelagliptin/Trelagliptin succinate TRELAGLIPTIN CAS 865759-25-7 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile Zafatek) Trilagliptin TrelagliptinQ: What is Trelagliptin Q: What is the CAS Number of Trelagliptin Q: What is the storage condition of Trelagliptin Q: What are the applications of Trelagliptin Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-flChemicalbookuoro- Trelagliptin intermediate 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]- (S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile with 1/4 succinate Dioxo-1 (2H) - pyrimidinyl) methyl] -4- Trelagliptin, 10 mM in DMSO 13C,D3-Trelagliptin 865759-25-7 C18H20FN5O2 API Trelagliptin Inhibitors